CEO & Co-Founder @DaffyGiving 🦍 Helping people be more generous, more often. 🙏 Inevitably optimistic. Slightly amusing. Always talking.
Silicon Valley
Joined March 2007
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Adam Nash retweeted
We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life.
Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown.
With Claude, we’ve found results that might bring us closer to solving that mystery.
Until now, vaults were only known in the cells of complex things like animals and plants. We have shown that similar proteins from bacteria (and the viruses that infect them) can also assemble into vaults. Finding the structures in these simpler forms of life may make it easier to investigate their function in our own cells.
For our life sciences team, the project was also a demonstration of the potential (and the limitations) of using AI to accelerate science.
In our full piece, we discuss how Claude was able to dramatically speed up some stages—manually determining the vault particle’s structure would have taken weeks to months of painstaking work, but here it took days. We also discuss how Claude made some simple mistakes along the way, and how we collaborated with our machine learning researchers to address them.
Read more: anthropic.com/research/inves…
Adam Nash retweeted
Anthropic has launched the roadshow for its proposed initial public offering: anthropic.com/news/roadshow-…
Legal disclaimer: A registration statement relating to these securities has been filed with the SEC but has not yet become effective. These securities may not be sold, nor may offers to buy be accepted, prior to the time the registration statement becomes effective. This post does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.
Adam Nash retweeted
Introducing Claude Fable 5.2 and Claude Mythos 5.2, designed to tackle the most daunting technical challenges.
They’re capable collaborators on ambitious projects in many fields, and show improvements in areas like coding, reasoning, and vision.
Adam Nash retweeted
Hilarious: fundamental physics is immune to AI because it can be neither theoretically validated nor empirically tested.
Adam Nash retweeted
Claude Fable 5.2 is available today on all paid plans, on the Claude Platform, and on all major cloud platforms.
It’s $8 per million input tokens and $40 per million output tokens, down from $10 and $50.
Read more: anthropic.com/claude-fable-a…
Adam Nash retweeted
A blowout quarter 🚀🛰️Today we reported $RKLB Q3 2026 financial results and the numbers speak for themselves.
Full results: investors.rocketlabcorp.com/…
Adam Nash retweeted
Interesting you have that perception. I actually have been a loud voice saying NASA pivoted too far with commercialization into areas where there was no obvious business case or market, unfairly shifting the impossible burden onto others, and have been working to fix that, bringing some balance to the Force and restoring core competencies, rebuilding the workforce, and turning NASA Centers into builders again. We will finish 2026 with 20,000 civil servants, up from 14,000 at the beginning of the year.
And I am not aware of any science programs that I cut. Certainly, the prior administration canceled MSR, and rightfully so over cost growth (though I would love to re-attack and find a better, more affordable way to get those samples), and NASA science leadership has to be able to pivot away from older programs to invest in new missions. I know I helped add several missions, including MoonFall, SkyFall, and PROMISE, while championing a 'Nuclear NASA' to send missions to Enceladus and Uranus. For those who have doubts, talk to the people doing the work at the NASA Centers and decide for yourself.
Articles like this are incredibly frustrating.
Every economist quoted never actually outlines how limiting data center growth would improve the economy by any objective measure.
Vibes & bias. 🤦♂️
nytimes.com/2026/11/09/busin…
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Adam Nash retweeted
Neat idea. I think Feynman also was known to have large stacks of unpublished work....
Been running Opus 5.5 agents over the notebooks of Gauss, Riemann, Hilbert and Grothendieck. around 12,000 pages so far. Heres the best finding so far:
Riemann's 1860 shock wave paper is famous for getting the energy part wrong however his unpublished sheets at Göttingen have it right the Rankine Hugoniot conditions a decade or two before Rankine and Hugoniot plus results usually dated 19061937, all in his own notation. A second sheet in another folder has the same physics.
There are probably thousands of potential undiscovered stuff in the research papers of the smartest ever to live imo all of them should be made public and reviewed by ai years of work can probably be transcribed by agents in days
Wow. James Gunn out at DC. 🔥 hollywoodreporter.com/movies…
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Love #Superman. Always have. 💗
Was very worried about @JamesGunn taking the mantle here, given that many of the elements he loves about comics are contrary to the character.
But it was good. Not great, but good.
But boy, did he do Jor-El & Lara dirty. Unnecessarily. 😢
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Adam Nash retweeted
I captured this photo October 13th, 2024. It was a moment I’ll never forget.
On Friday, the starship booster will do this again.
Then, after completing 14 orbits around Earth, the upper stage will reenter Earth’s atmosphere and be caught by the same tower.
Good luck, @SpaceX
Adam Nash retweeted
The next chapter of humanity's story in space won’t just be about what we can launch from Earth and return safely—it will be about what we can build in space, using in situ resources. I have always believed that the Moon will be a critical part of that process, and it starts with creating a more sustained presence. That’s why I’m so excited about the two task orders Impulse Space has been awarded by @NASA in support of the Moon Base program.
Establishing an enduring presence on the lunar surface starts with a robust in-space transportation system. That’s not an easy problem to solve, because it’s not a one-size-fits-all solution: you need a variety of spacecraft with a variety of performance profiles, just like we have cars, trucks, trains, and planes on Earth.
This is exactly what we’re building at Impulse. We’re creating an end-to-end infrastructure of in-space mobility, starting with our Mira, Helios, and lander vehicles. And we couldn’t be more proud to put our spacecraft to work supporting this pivotal mission for NASA.
I’m grateful to Administrator Isaacman and the team at NASA for the visionary leadership they’ve demonstrated to keep our nation’s space program at the forefront of innovation. I fully believe we’re at the beginning of the true space age, and that the Moon will play a pivotal role.
On a personal level, the opportunity to build spacecraft for lunar missions is one of the crowning achievements of my career, and a primary reason I founded ImpulseUndoubtedly, it’s also one of the most challenging; but to echo the famous sentiment of President Kennedy, we choose to do the hard thing because it requires our best work and skill. We’ve got the smartest people in the industry working on these missions at Impulse, and I’m confident in our ability to succeed.
It will take a lot of hard work to get there, so if you’re also passionate about building something—engines, software, COPVs, avionics, or anything else—check out our open roles at impulsespace.com/careers.
Ad lunam,
Tom
Ad lunam Impulse! 🚀
We are proud to announce that @NASA has awarded Impulse two missions as part of its Moon Base program, an ambitious effort to establish humanity’s first permanent lunar outpost.
For decades, the Moon has been a place we’ve visited. Now, Impulse is delivering the transportation to make it a place we can call home.
Read more: impulsespace.com/updates/imp…
Adam Nash retweeted
Many flowers with six petals or tepals follow the geometry of a regular hexagon. Mark six points 60° apart on a circle, join every second one, and two equilateral triangles appear, forming a six-pointed star inside the hexagon.
The numbers follow from the circle. The central angle is 360°/6 = 60°. Each side of the hexagon spans a 60° arc, so its length is 2R sin 30° = R, equal to the radius. Each interior angle is (6 − 2) × 180°/6 = 120°, which is why hexagons tile the plane with three meeting at every corner.
Lilies, squills and the Star of Bethlehem show this pattern. In many monocots the flower is built from two whorls of three parts, offset by 60°, which produces the two-triangle arrangement.
Seems like a pretty good empirical test of Roko’s basilisk. 🤔
SITUATION DETECTED: Bloomington, Indiana's city council voted unanimously this week to ban any recursively self-improving entity capable of greatly outperforming all humans on all cognitive tasks from inside city limits, citing existential hazards and loss of human control.
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Adam Nash retweeted
The funny thing is, if you had invested $1K in it as an angel, you would have made about $250K, in contrast to the much lower amount of carry I would have made. I think direct angel investing can make you a lot more money than a fund job if you're not in charge.
Adam Nash retweeted
Ad lunam Impulse! 🚀
We are proud to announce that @NASA has awarded Impulse two missions as part of its Moon Base program, an ambitious effort to establish humanity’s first permanent lunar outpost.
For decades, the Moon has been a place we’ve visited. Now, Impulse is delivering the transportation to make it a place we can call home.
Read more: impulsespace.com/updates/imp…
Adam Nash retweeted
LIVE: Big updates on our efforts to build a Moon Base! @NASAAdmin and agency leaders are sharing the latest progress and new developments toward establishing a sustained human presence on the lunar surface. teapawt.net/i/broadcasts/2ybAenAyp…
You'll notice that, somehow, the value of a Harvard PhD is not included in this framing, nor the comparative value of a Harvard vs. Copenhagen degree.
Harvard PhD students are on strike, postdocs and lecturers will probably join next week.
Harvard PhD students obviously enjoy great privilege, but this privilege is not reflected in our wages.
Here is a comparison to my "alma mater". There is room to move.
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