A 40-year-old man presented with inflammatory arthritis, rash, facial swelling, abdominal pain and weight loss: cle.clinic/3uHBbAQ

Early genetic testing may play an important role in breast cancer treatment decisions for young women with BRCA1 or BRCA2 mutations. A new international study found that patients who knew their genetic status before surgery were more likely to undergo bilateral mastectomy than those who received their results later: cle.clinic/3W1vwU4

Strong leadership starts with listening, building relationships and finding ways to help teams succeed. From workforce planning to using technology to improve operations, our organization is focused on creating more effective processes and supporting caregivers as the organization grows. Our Senior Director of HR Operations, reflects on her first year in the role and shares how collaboration and innovation are helping build a foundation for the future: cle.clinic/4yzl3N6

A 38-year-old patient presented with a retroperitoneal schwannoma encasing the superior mesenteric artery. Her tumor had been diagnosed five years prior at roughly 9.4 × 8.9 cm, but a previous resection attempt was aborted due to vascular involvement. More about the case: cle.clinic/4jBg36S

IOL implantation in Marfan ectopia lentis can offer visual benefits without greater postoperative risk than aphakia, shows a large cohort study: cle.clinic/4iaD6mx

Lung volume reduction is an effective treatment for some people with severe chronic obstructive pulmonary disease, but it is often underused: cle.clinic/4v0UXAN

A 46-year-old woman presented with Raynaud phenomenon, sclerodactyly, rapidly progressive skin tightness, polyarthralgia with morning stiffness, proximal myopathy, dry eyes and mouth, and gastroesophageal reflux disease: cle.clinic/4zQKESZ

Pediatric nursing requires a tailored approach to care at every developmental stage. Understanding age-specific physical and emotional needs helps nurses build trust, improve communication and support better patient experiences: cle.clinic/4sfRUVz

Low testosterone can signal broader health concerns involving weight, metabolic health, sleep and lifestyle. An expert explains why comprehensive evaluation and a whole-person treatment approach matter: cle.clinic/4hXQ1cW

By the time she was 35 years old, a female patient had spent more than half her life experiencing symptoms from systemic lupus erythematosus (SLE) with significant disruptions to daily living. Over time, her disease stopped responding to a number of therapies. She became our fourth participant in a CART T-cell therapy trial for lupus and has remained in drug-free remission for more than a year: cle.clinic/4vfSnqU

Older adults are most likely to have heart failure, yet often least likely to receive guideline-directed therapy. A new scientific statement examines why, and how clinicians can balance benefit, risk and quality of life: cle.clinic/3W0QnXw

In a study involving pregnant patients with chronic hypertension, point-of-care echocardiography reliably diagnosed pathologic left ventricular remodeling: cle.clinic/4hCVHJz

A 2-month-old presented after being born premature with life-threatening congenital heart defects. He is our youngest patient to undergo a rare procedure where surgeons reroute the arteries to establish healthy blood flow: cle.clinic/41z7Q9c

New findings suggest certain inflammatory proteins in CSF and plasma are early signals of cognitive decline in people at risk for Alzheimer’s disease: cle.clinic/4yOf6fD

A pharmacist explains what new weekly insulin options mean for clinicians caring for patients with diabetes: cle.clinic/4ehnT1W

Diagnosing a joint infection after a hip or knee replacement is not always straightforward. Researchers are working to identify new biomarkers that could help detect periprosthetic joint infections earlier and more accurately. Better diagnostic tools may help patients get the right treatment sooner and improve outcomes: cle.clinic/4uFh0h5

Virtual second opinions can clarify complex diagnoses and treatment plans while supporting care from local physicians: cle.clinic/4hSHKr0

In aortic valve, root or LVOT surgery, surgeons can use landmarks on preop cardiac CT to help them avoid the conduction axis and prevent heart block: cle.clinic/4wRWWZa

Could oxidized phospholipids help explain why lipoprotein(a) is harmful? A new analysis finds that lepodisiran-driven Lp(a) reductions closely tracked phospholipid declines, adding biological context as phase 3 outcomes data are awaited: cle.clinic/4zMORrn

A 35-year-old male with a history significant for chilblain lupus and childhood immune thrombocytopenic purpura presented to the hospital with right perioral numbness, dysarthria and right arm numbness. He denied new shortness of breath, chest pain, worsening leg swelling, dysuria and hematuria, as well as any history of blood clots. More about the case: cle.clinic/3TvIyrJ