Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also featuring two Review articles on the 3D genome in cancer, and the regulation of noninfectious granulomas. Click here to learn more: ➡️ genesdev.cshlp.org/content/4…

REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics By Smith et al. and Yu (Sunny) Liu ➡️ genesdev.cshlp.org/content/4… @YuLiu_Sunny @CeiFccc @FoxChaseCancer @FCCCAcademics #cancer #epigenetics #chromatin

🎙️ G&D Voices: Author David Gutmann 🎙️ A longstanding connection to CSHL makes publishing in G&D especially meaningful. Here is why scientists choose G&D to share their research.

RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency By Fan et al. and Marikki Laiho ➡️ genesdev.cshlp.org/content/4… @JohnsHopkins #cancer #ribosome #translation #mTOR

RESEARCH COMMUNICATION: Chromosomal requirements for formation of multivalent human nucleoli By Krystyna Giemza, Hazel Mangan, and Brian McStay ➡️ genesdev.cshlp.org/content/4… @Galway_Research #chromosome #nucleolar #ribosome

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Lymphatics-epicardial cross talk via Reelin controls cardiac growth By Zhou et al. and Guillermo Oliver ➡️ ow.ly/olCe51035py @NU_Lymphatics @NUFeinbergMed #lymphatics #cardiac #repair #regeneration

RESEARCH PAPER: Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes By Ma et al. and ens Lykke-Andersen ➡️ genesdev.cshlp.org/content/4… @UCSanDiego #RNA #RNAdecay #RNAsplicing

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The hnRNPA1 D262V amyotrophic lateral sclerosis (ALS) mutation is linked to mitochondrial dysfunction By Lee et al. and Donald Rio ➡️ ow.ly/M2oO5102hCe #ALS #mutation #neuron #mitochondria #RNA

📽 G&D Tapes 📽 G&D authors tell us about how MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis. Learn more in these complementary studies by Anindya Bagchi’s group: ➡️ ow.ly/cgwh5102g73 #cancer #MYC #KRAS #lncRNA

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Initial perturbations triggered by p53 loss in stem cells By Fan et al. and John Abrams ➡️ ow.ly/ss9b5102hwF #cancer #p53 #stemcell

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity By Ashour et al. and Nima Mosammaparast ➡️ ow.ly/hhmQ51012Xt #DNArepair #cancer #chemotherapy

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: A HUWE1 regulatory helix gates ASCL1 degradation through its C-terminal phospho-degron in small cell lung cancer By Masuzawa et al. and Matthew Oser ➡️ ow.ly/Sq7451013oy @Oser_Lab #lungcancer #ubiquitin #transcriptionfactor

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Decoding anterior–posterior patterning cues into embryo-wide binary fate decisions through recruitment-mediated targeting By Xiao et al. and Zhuo Du ➡️ ow.ly/SCJk5100YF0 #patterning #Wnt #Celegans

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: MCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation By Bektash et al. and Masato Kanemaki ➡️ ow.ly/beKJ50ZXOwQ @NIG_idenken #DNA #DNAreplication #helicase

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Chromosomal requirements for formation of multivalent human nucleoli By Krystyna Giemza, Hazel Mangan, and Brian McStay ➡️ ow.ly/cfpL50ZXOf6 @Galway_Research #chromosome #nucleolar #ribosome

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Sharp cell type boundaries emerge from coordinated morphogen signaling By Li et al. and Peggy Myung ➡️ ow.ly/PFjR50ZXNVR @Yale #morphogen #WNT #Hedgehog #patterning

🆕 ADVANCE ONLINE 🆕 REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics By Smith et al. and Yu (Sunny) Liu ➡️ ow.ly/YJS150ZW4Gj @YuLiu_Sunny @CeiFccc @FoxChaseCancer @FCCCAcademics #cancer #epigenetics #chromatin

ON THE COVER: MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis Artwork by by Jianhua Zhao Learn more in these complementary studies by Anindya Bagchi’s group: ➡️ ow.ly/35Eb50ZZsHm

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters By Gonzalez et al. and Pablo Navarro ➡️ ow.ly/LWC250ZXNv7 @pablonavarroLAB @institutpasteur #transcription #transcriptionfactor #mitosis #MYC

🎙 G&D Voices: Author Lluis Morey 🎙 G&D continues to inspire scientists and publish influential research. G&D author, Lluis Morey, tells us why he chooses to publish in G&D.