Husband, Father, and Associate Prof @UAlberta_FoMD. Studying in all things glia. Hoping to #endMS. [email protected]
Edmonton, Alberta
Joined July 2009
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A special thanks to Rebecca John who did such a great job with this project. Also for the funding from International Spinal Research Fund and the @ReeveFoundation, with support from @CIHR_IRSC and CRC
Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states
Jason Plemel retweeted
I'm thrilled to share our preprint entitled, "An MRI-informed histo-molecular analysis implicates ependymal cells in the pathogenesis of periventricular pathology in multiple sclerosis".
It has been an amazing journey, thanks so much to all!
Preprint: lnkd.in/gppiFSuk
Jason Plemel retweeted
Excited that George Melchor @thegliaguy's snRNAseq analysis of CNS #remyelination is now in Biorxiv... Remyelination is complicated, it takes a village. Congrat George on your excellent work! Thanks @Zeebamehrin @Jingwen_SMyelin and @Maryna_Baydyuk for contributing to this study. 😀
Dissecting the evolving cellular landscape of a remyelinating microenvironment biorxiv.org/cgi/content/shor… #biorxiv_neursci
Jason Plemel retweeted
New work that builds on the growing evidence for microglia contributing to the seeding of amyloid plaques in a different model of AD. Curious as to whether differences exist between parenchymal and vascular amyloid seeding. nature.com/articles/s41467-0…
Jason Plemel retweeted
Our latest review on microglia metabolism across different neurodegenerative disorders is out now in J Neuroinflammation. @KaushikLab is proud to contribute to this emerging field!! Big shout out to @Msadeghdoust for spearheading the work. Great team work!
link.springer.com/article/10…
Jason Plemel retweeted
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
biorxiv.org/content/10.1101/…
Jason Plemel retweeted
Interested in studying type I interferonopathy? Here is a primer on existing tools from the self proclaimed "AGS supergroup". doi.org/10.1111/imr.13413
Jason Plemel retweeted
CW: Martha Cardinal, 76, of Saddle Lake Cree Nation in central Alberta is a 60s Scoop and residential school survivor. She shares some of the abuse she endured as a child at the hands of staff and clergy at Blue Quills Residential School. Martha shares her story with people because she wants to help others heal from trauma. She leads healing workshops, picks medicines, teachings her Cree language and is a mother of four children, multiple grandchildren and great-grandchildren. She survived the horrors of attempted genocide. She forgave her abusers and has undertaken a lifelong journey of healing.
On this Orange Shirt Day and the coming National Day of Reconciliation, listen to survivors, honour them. Learn our history and please do your part to rebuild from the brokenness. 🧡🧡🧡
Jason Plemel retweeted
The NERD Run | Neuroscience and Mental Health Institute
🏃🏻♀️💨 for Neuroscience Research on Saturday ualberta.ca/en/neuroscience-…
Jason Plemel retweeted
I’m very excited to share that our paper describing the cellular origin of pathological angiogenesis in EAE/MS and the role of VEGF-A signaling is now available online @NatureNeuro
nature.com/articles/s41593-0…
Jason Plemel retweeted
Another beauty from one of the BEST in the myelin game! @KlausNave 👏🏻👏🏻👏🏻👏🏻
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve | Nature Neuroscience nature.com/articles/s41593-0…
Come on out, Edmontonians, to the annual NERD run in support of the Neuroscience Institute at the University of Alberta this September 14th. @NMHI_UofA @UAlberta_FoMD raceroster.com/events/2024/8…
Jason Plemel retweeted
The University of Notre Dame is hiring a cluster of 5 new Assistant Professors in Neuroscience starting this year, focused on cellular, molecular, or computational neurobiology.
Come be a colleague! More information here:
apply.interfolio.com/152596
Please share and retweet!
Jason Plemel retweeted
Our annual lab #barbecue was a blast.
#Researchers #PhD #Lab #masters #gradschool #fun #food #gathering #summer
Jason Plemel retweeted
Happy #Fridayfluorescence everyone!
Can't remember what stains these were, but :
1) look at how complex cell morphologies are when you image at high resolution!
2) the amount of cellular debris in a demyelinating lesion pops up!
#Microscopy #Fluorescence #Leica #100x #microglia
Jason Plemel retweeted
Microglial cGAS–STING signaling underlies glaucoma pathogenesis | PNAS pnas.org/doi/10.1073/pnas.24…