Developmental neurobiologist using cerebral #organoids to study brain size and evolution. Opinions my own.

Cambridge, England
Joined February 2015
We've started a new Google group dedicated to Brain organoids. Check it out and join us! We want to create an open community to discuss methods, technical difficulties, and uses of organoids: groups.google.com/forum/#!fo…
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Super cool new work from the McDole lab on the extreme stress primordial germ cells have to endure on their journey to the gonads during embryonic development. It’s wild that a new generation is even possible after all that! doi.org/10.1101/2025.03.03.6…
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Madeline Lancaster retweeted
Very cool preprint by my colleague Kate McDole and her postdoc Katie Goodwin @CellBiol_MRCLMB using beautiful imaging and quantitative methods to understand the wondrous migrations of primordial germ cells in mouse embryos doi.org/10.1101/2025.03.03.6…
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This is a fun read, especially with the cool scrolling animations 🤩
What's so special about the human brain? 🧠 Learn the answers to this age old question: nature.com/immersive/d41586-…
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Dendritic spines are a neuroanatomical site of synapses, so counting their number can provide an indication of synapse number. Bianchi et al. (Cerebral Cortex 2013) painstakingly counted dendritic spine number on cortical neurons in 4 cortical regions in human and chimpanzee.
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On average, chimp cortical neurons contained 221 spines, while in human it's 980. So, 980 x 16 billion = 15.68 trillion synapses in human cortex, while 221 x 8 billion = 1.768 trillion in chimpanzee. A difference of almost 14 trillion, more than all the galaxies in the universe!
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What an honour it was to visit UHasselt Biomed and receive an honorary doctorate. It’s a vibrant and growing community of biomedical scientists doing exciting work in immunology, cardiometabolic, and neuroscience!
25-jarig bestaan @BIOMED_UHasselt: onderzoeksinstituut reikt eredoctoraat uit aan Madeline Lancaster, pionier binnen de biomedische wetenschappen. bit.ly/3zTMh90 @Cambridge_Uni @mad_lancaster
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On the latest #NBTForum podcast, Barbara Cheifet speaks with Madeline Lancaster and Sergiu Pasca about neural organoids — how they are being used to study both basic biology of the brain and their future impacts on disease research shows.acast.com/forum/episod…
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Check out this fantastic opportunity in the McDole lab here at the LMB. Right at the interface of imaging and development!
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Sergiu and I had a nice chat with Barbara about all things neural organoids. Check it out in the podcast link 👇
Had a great conversation with Madeline @mad_lancaster about human multi-cellular models of disease, evolution and development for the @NatureBiotech Forum Podcast moderated by Barbara @BCheifet
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Some amazing northern lights over Cambridge on a beautiful warm clear night!
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Check out this upcoming organoids conference packed full of great speakers pushing the limits of organoid technologies!
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Madeline Lancaster retweeted
How is it possible that the UK's emissions have declined so much? This is the main reason. The UK left coal behind. The UK's CO₂ emissions from coal are today lower than at any point since 1800.
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