An analysis of 3,653 public comments on a proposed rule change that would dramatically alter the decision-making processes for federal grants found that nearly 88% of organizations opposed the revisions. Common concerns included transparency, procedural safeguards, grant administration, and the stability of research funding. Read more: bit.ly/3UQ3BpR

A new Annals #GraphicMedicine from Yujin Kim reflects on the cycles of life. bit.ly/4zRedDD

In a nationwide cohort study of more than 6.3 million Korean adults aged 20 to 39, researchers found that #obesity was associated with a higher risk of developing #cancer before midlife. Risk increased with greater levels of obesity and was highest among people with severe obesity and abdominal obesity. These findings highlight the potential importance of weight management early in life as a strategy for preventing early-onset cancers. Read here: bit.ly/4kjAup6

A new issue of Annals of Internal Medicine is online now. Read the latest at bit.ly/4rhjz7F

In a new I.M. Matters News Q&A, LeRoi Hicks, MD, MPH, MACP, @ACPIMPhysicians' new EVP/CEO, discusses physician well-being, evidence-based medicine, health equity, AI, and the future of the profession. Read the interview here: bit.ly/48g4kDP

In a personal essay, Annals Deputy Editor Stephanie Chang, MD, MPH, reflects on caring for her aging parents while navigating delays, uncertainty, guilt, and learning to be a physician caregiver.  Read here: bit.ly/4snHOC6

Annals of Internal Medicine’s specialty collections include research, reviews, and expert opinion on topics ranging from cardiology to prevention efforts. View our specialty collections here: bit.ly/4qKVaX4

A new editorial raises important questions about Medicare Advantage follow-up treatment and payment policy related to routine in-home assessments that identify an increasing number of cardiovascular conditions. Find out more: bit.ly/4zSrJak

A new Annals for Educators is online now. Read clinical practice points for recent articles on alternative lung cancer screening eligibility criteria, the economic impact of the New Mexico measles outbreak, and much more. bit.ly/4i9DXUI

An analysis of more than 21 million Medicare Advantage beneficiaries found that an increasing share of #cardiovascular risk factors and heart conditions were diagnosed during in-home health risk assessments. However, patients diagnosed during these visits were less likely to receive treatment than those diagnosed in traditional health care settings. The findings highlight potential gaps between diagnosis and treatment as policymakers consider reforms to Medicare Advantage. Read the study here: bit.ly/4icfttY

The latest episode of the Annals #ConsultGuys is online now. In this episode, Drs. Geno Merli and Howard Weitz discuss the evaluation and care of a woman who presents with symptoms suggestive of carpal tunnel syndrome. bit.ly/4iArv1y

A new study found that moderate to severe depressive symptoms affected 17.1% of adults with #Type1Diabetes, while 16.2% reported moderate to severe anxiety symptoms. Women, younger adults, and those with less than a high school education were at particularly high risk. The findings highlight the importance of #MentalHealth screening and support as part of comprehensive diabetes care. bit.ly/3WGDt12

On October 14, 2026, @ACPIMPhysicians and Annals of Internal Medicine hosted a panel discussion on the effective and safe management of vasomotor and other symptoms that can significantly affect women's quality of life during menopause. The conversation offered expert perspectives and practical guidance for clinicians caring for women during #menopause. Read a summary and watch the full discussion here: bit.ly/4enR5Ew

A new study found that large language models generally followed Choosing Wisely recommendations, with low rates of overuse and underuse. In an editorial, Deborah Korenstein, MD, and Daniel J. Morgan, MD, MS, argue that evaluations of clinical #AI should measure not only diagnostic accuracy but also its ability to reduce unnecessary care, avoid harm, and improve patient outcomes. bit.ly/4icLDWo

A new commentary examines the FDA’s recent approval of bemotrizinol, the first new sunscreen ingredient added to the U.S. monograph in 27 years. The authors argue that this approval is an important step toward modernizing U.S. sunscreens, which currently offer fewer UV filter options than those available in Europe. Expanded access to modern UV filters could benefit patients at increased risk of skin cancer, photosensitivity, and sun-related skin damage. Read here: bit.ly/4zOfagc

In 225 clinical scenarios based on Choosing Wisely recommendations, LLMs aligned with evidence-based guidance, recommending potentially unnecessary tests or treatments in just 5.4% of responses and rarely withholding appropriate care. Researchers found that LLMs were more likely to suggest unnecessary care in scenarios where clinical guidance is debated or symptoms could reasonably justify additional testing.   These findings suggest that commercial LLMs generally align with evidence-based principles of medical restraint while highlighting opportunities for targeted improvement. bit.ly/3UevlnQ @deanarielmd @ClalitHealth @GuyLaban @bengurionu

A new editorial highlights #IronDeficiency in women as a major but often overlooked public health concern. The authors point to growing evidence linking maternal iron status during early pregnancy to offspring neurodevelopmental outcomes and call for routine ferritin measurement, greater attention to heavy menstrual bleeding, and earlier treatment of iron deficiency before conception. bit.ly/4sbNRJX

In a new episode of Annals on Call, Dr. Centor @medrants discusses the use of carvedilol in patients with cirrhosis with Drs. Kueiyu Joshua Lin and Tracey G. Simon. bit.ly/47rfIMX