Jen A-Brett MD PhD ATSF | 🫁 transplant & critical care | mechanisms of #chronic airway disease | cytokines and extracellular vesicles | @CSCTR_org President
St Louis, MO
Joined August 2018
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Congrats to @DuttSohini on her first publication in the lab! Stay tuned for her exciting work, much more to come!
doi.org/10.1016/j.healun.202…
Jen A-Brett retweeted
Proud to celebrate Omar Osorio, PhD @JABLab3, a 2026 Henry Christian Award recipient from the American Federation for Medical Research. A national honor recognizing outstanding early-career research. #WashUMedPCCM @WashUDeptMed
Read more>pulmonary.wustl.edu/omar-oso…
I mean, who doesn’t think AP-1 is a central player? We agree 😁
Apparently it's AP-1 controls cellular memory week. Congrats @chris_cowley14 ! I guess I convinced you AP-1 is so interesting that you never need to work on anything else again...
science.org/doi/10.1126/scie…
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Jen A-Brett retweeted
AP-1 TFs control everything, example #312:
nature.com/articles/d41586-0…
nature.com/articles/s41586-0…
Jen A-Brett retweeted
With just a few minutes of hands-on set-up, #DemeterEVPrep's hands-off, automated workflow isolates #EVs from up to 8 samples simultaneously. Visit us at @SelectBio's Next-Gen Instruments & Tools Driving EV Research 2026 to learn how Demeter EVPrep can speed your discovery. 🔗👇
Abstract deadline is today!!! Join @CSCTR_org @AFMResearch for a fantastic program!
csctr.org/annual-meeting/202…
Minus the ‘and providers’ yes, you are correct.
If we fined insurers and providers $100 every time they over-billed, incorrectly denied care or misrepresented any amount of patient out of pocket, we could pay of the national debt
They play on the fear and information asymmetry that exists in healthcare
Break them up. Make them divest non insurance companies. And when we are done with the insurance companies , we go to the hospitals and then to the pharma wholesalers. Break em up. Make the markets efficient again.
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Jen A-Brett retweeted
A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies.
Learn more in a new #SciencePerspective: scim.ag/4j8UAA6
Jen A-Brett retweeted
Spermidine deficiency induces BNIP3/LC3B-mediated mitophagy in the salivary glands of accelerated aging mice
sciencedirect.com/science/ar…
Jen A-Brett retweeted
New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep).
Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep.
They found what actually matters - and why some sleeping pills might undermine it 🧵
Jen A-Brett retweeted
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations nature.com/articles/s43587-0…
Jen A-Brett retweeted
Is fibroblast proliferation important in pulmonary fibrosis? Finally an answer - great paper by the super team of Christopher Molina,Tatsuya Tsukui, and Dean Sheppard
#זScienceMatters
#CureIPF
jci.org/articles/view/191826
Let’s be data driven! Supported access to professional coaching should be a standard part of every contract 😁
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Thanks for the shout out!
The @JABLab3 led by Jen Alexander-Brett, MD, PhD, @WashUMedPCCM analyzed COPD biospecimens released from cells into the airways. Findings help uncover cellular processes that drive chronic inflammation, tissue damage, and poor lung function.
Learn more> internalmedicine.wustl.edu/b…
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Jen A-Brett retweeted
🌎 Today is #WorldAlzheimersDay! Make a gift in honor of the 55 million people worldwide living with Alzheimer’s or another dementia and have DOUBLE the impact on accelerating research and helping provide vital care and support: bit.ly/4pDc2iY. #ENDALZ
Jen A-Brett retweeted
I recently learned that the novelist, Cormac McCarthy, spent several years at the Santa Fe Institute helping scientists write papers.
His advice was condensed into a brief Nature column. The first three points, and some of the final points, are really good. (h/t @eryney_ok)
Thanks for including us! @omar_ohhh @WashUMedPCCM @WashUDeptMed
Every #EV researcher knows - the quality of the sample is the quality of the experiment. If the sample quality is poor, the analytical result will be compromised. We discuss more with @JABLab3 in our latest blog post. #extracellularvesicles #EVs hubs.ly/Q03Hr9xv0
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