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JAMA Psychiatry

@JAMAPsych

JAMA Psychiatry is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

 Chicago, IL
ja.ma/tjamapsychiatry
Joined July 2009
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Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)Photo by JAMA Psychiatry (@JAMAPsych)
🧠 Among young adults at varying #ManiaRisk, greater left ventrolateral prefrontal cortex activation during reward expectancy was associated with lower delay discounting, consistent with greater sensitivity to reward value. ja.ma/4iEX2hX
Neural Markers of Reward Valuation and Impulsive Decision-Making

Neural Markers of Reward Valuation and Impulsive Decision-Making

This cross-sectional study evaluates potential neural markers associated with delay discounting behavior in individuals at risk of mania or hypomania.

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Among adults with serious mental illness, #GLP1 receptor agonists vs #SGLT2 inhibitors were associated with lower mortality and fewer major cardiovascular events, with greater absolute benefit in serious mental illness. ja.ma/3UysZQH
GLP-1 Receptor Agonists, Mortality, and CV Outcomes in Mental Illness

GLP-1 Receptor Agonists, Mortality, and CV Outcomes in Mental Illness

This study assesses the association of glucagon-like peptide-1 receptor agonists vs sodium-glucose cotransporter-2 inhibitors with all-cause mortality and major adverse cardiovascular events among...

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In 2027, JAMA will convene leaders across #medicine, research, #technology, industry, and #policy to address how #AI will reshape health care and biomedical science. Learn more: ja.ma/3WcdPRX #HealthAfterAI #JAMASummit
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💻 Artificial intelligence (AI) models in #Psychiatry may identify predictive signals, but deployment requires routine-care predictors, validation across settings, and evidence that predictions support actions that improve care. ja.ma/4AxmqNZ
The Clinical Utility of AI-Based Prediction and Stratification Models

The Clinical Utility of AI-Based Prediction and Stratification Models

This article outlines a strategy of pursuing “prediction without hype” and judging AI by whether it is trustworthy, transportable, and useful at the point of care.

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🧠 In postmortem brain tissue of patients with #Schizophrenia, the dorsal claustrum showed extensive transcriptome alterations, with upregulation of immune response genes and downregulation of mitochondrial and oxidative phosphorylation genes. ja.ma/3V5Cvev
Claustrum Transcriptome Alterations in Schizophrenia

Claustrum Transcriptome Alterations in Schizophrenia

This case-control study investigates schizophrenia-associated transcriptome alterations in the dorsal claustrum.

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📊 Among people who inject drugs, a mobile unit providing integrated #HIVPreexposureProphylaxis and #MedicationsForOpioidUseDisorder did not improve either primary outcome vs peer navigation alone, but all-cause mortality was lower at 52 weeks. ja.ma/48EijmZ
Infographic from JAMA Psychiatry showing findings of an RCT on mobile units for addiction and HIV prevention. It details population, intervention, findings, and primary outcomes with data on PrEP and MOUD use among 409 participants across 5 US cities.

ALT Infographic from JAMA Psychiatry showing findings of an RCT on mobile units for addiction and HIV prevention. It details population, intervention, findings, and primary outcomes with data on PrEP and MOUD use among 409 participants across 5 US cities.

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💬 Viewpoint: Office-based #Methadone treatment for #OpioidUseDisorder could expand access beyond current programs, but implementation would require careful oversight to balance patient access, safety, and coordination with pharmacies and specialty care ja.ma/3Wdf8jx
A screenshot of a JAMA Psychiatry article titled 'Office-Based Methadone Treatment\u2014Has the Moment Arrived?' by Brendan Saloner, PhD, and Minna Song, MPH, published online on November 4, 2026.

ALT A screenshot of a JAMA Psychiatry article titled 'Office-Based Methadone Treatment\u2014Has the Moment Arrived?' by Brendan Saloner, PhD, and Minna Song, MPH, published online on November 4, 2026.

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📝 In wartime Ukraine, a civilian hospital embedded #TraumaInformed mental health care through proactive psychiatric rounds, structured triage, stabilization-first care, and longitudinal case management across medical and rehabilitation services. ja.ma/4sM1MqJ
The Unbroken Integrative Psycho-Trauma Care Model

The Unbroken Integrative Psycho-Trauma Care Model

This Special Communication describes the implementation and clinical workflow of the Unbroken Integrative Psycho-Trauma Care Model, a multidisciplinary health system approach for delivering trauma-...

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📊 #AnorexiaNervosa and #BulimiaNervosa contribute substantially to global health loss, and their prevalence is forecast to continue increasing, supporting stronger prevention, early detection, and evidence-based treatment capacity. ja.ma/4kkyJrO
Global Burden of Anorexia Nervosa and Bulimia Nervosa, 1990 to 2023, With Forecasts to 2050

Global Burden of Anorexia Nervosa and Bulimia Nervosa, 1990 to 2023, With Forecasts to 2050

This cross-sectional study estimates the global, regional, and national prevalence and disability burden of anorexia nervosa and bulimia nervosa—and mortality attributable to anorexia nervosa—from...

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💬 Viewpoint: #Suicide research should prioritize intensive longitudinal study of patients with suicidal thoughts using deep phenotyping, wearable sensing, and digital monitoring to support more precise prevention and treatment. ja.ma/4jLDQBe
Bar graphs comparing current and proposed approaches to suicide risk. A shows episodic observation with large unobserved post-discharge gaps. B shows a continuous, multimodal trajectory tracking various metrics across time with expected recovery and deviation alerts.

ALT Bar graphs comparing current and proposed approaches to suicide risk. A shows episodic observation with large unobserved post-discharge gaps. B shows a continuous, multimodal trajectory tracking various metrics across time with expected recovery and deviation alerts.

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📊 Among patients with #OpioidUseDisorder, mindfulness-Oriented Recovery Enhancement reduced prefrontal responses to drug cues, increased responses to natural rewards, and prolonged abstinence vs psychoeducational supportive therapy. ja.ma/4yMt7u6
Line graph titled \"Figure 3. Line Graph Showing Abstinence Length Between Treatment Groups Over Time.\" It compares MORE and PST groups across Baseline MRI, Posttreatment MRI, and Follow-up visits, showing a greater increase in abstinence for MORE.

ALT Line graph titled \"Figure 3. Line Graph Showing Abstinence Length Between Treatment Groups Over Time.\" It compares MORE and PST groups across Baseline MRI, Posttreatment MRI, and Follow-up visits, showing a greater increase in abstinence for MORE.

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📊 Among pregnant females with #OpioidUseDisorder, Black patients initiating #Buprenorphine had higher treatment discontinuation than White patients during pregnancy and through 1 year post partum, indicating potential inequities in continuity of care. ja.ma/4j9x3AX
Racial and Ethnic Disparities in OUD Treatment Discontinuation Among Pregnant Females

Racial and Ethnic Disparities in OUD Treatment Discontinuation Among Pregnant Females

This cohort study examines racial and ethnic disparities in retention in buprenorphine and methadone treatment among pregnant females with opioid use disorder (OUD) in the US.

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📣 JAMA and the JAMA Network journals are issuing a call for papers on Women's Health. ➡️ Manuscripts submitted by November 15, 2026, will have the best chance for consideration for simultaneous publication on International Women’s Day. 🔗 Learn more: ja.ma/3UGKsGQ
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Among adolescents in substance use disorder treatment who used nicotine #ECigarettes, urine cotinine concentrations increased abruptly beginning in October 2024. ja.ma/4djp2G0
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Among people with #ParkinsonDisease and mood dysfunction, #Psilocybin was associated with lower systemic markers of inflammation and mitochondrial stress after treatment. ja.ma/4idaolc
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Early clinical studies suggest that low-intensity #FocusedUltrasound can modify symptom-relevant circuitry and may improve psychiatric symptoms, but translation will depend on safety standards, target validation, and standardized reporting. ja.ma/4j2g57A
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💬 Viewpoint: Evaluation of large language models in #MentalHealth care should reflect the realities of psychiatric practice and should not rely on isolated institutional efforts. ja.ma/3WE4iD3
Image from JAMA Psychiatry (@JAMAPsych)
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Among patients with major depressive disorder, #MachineLearning predicted relapse with moderate accuracy, but the best model used only clinical relapse risk factors. Multimodal data did not improve prediction. ja.ma/4yDTt1p
A forest plot titled 'Forest Plot of Unimodal and Multimodal Model Performances' comparing mean balanced accuracy (SD) across unimodal and multimodal models, with data points ranging mostly between 0.5 and 0.7.

ALT A forest plot titled 'Forest Plot of Unimodal and Multimodal Model Performances' comparing mean balanced accuracy (SD) across unimodal and multimodal models, with data points ranging mostly between 0.5 and 0.7.

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Greater exposure to adverse #SocialDeterminants was associated with neurobiological abnormalities in #SchizophreniaSpectrum conditions, linking SDOHs to clinical outcomes and supporting equity-oriented approaches. ja.ma/47DbOQS
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#SelectiveSerotoninReuptakeInhibitors are an essential component of perinatal mental health care, and treatment decisions in pregnancy should balance risks of untreated major depressive disorder with benefits and potential risks of treatment. ja.ma/4dYmM7b
Depression and SSRI Treatment During Pregnancy

Depression and SSRI Treatment During Pregnancy

This Special Communication outlines current evidence regarding effects of both major depressive disorder and selective serotonin reuptake inhibitor (SSRI) treatment on pregnancy and offspring...

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