Chemical Biologist & Research Groupleader at Max Planck & TU Dortmund. Interested in proteases, ubiquitin, the outdoors and more. https://xitter.cf/t.co/NiwEqrr21H
Dortmund, Germany
Joined August 2018
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Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you:
We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability.
biorxiv.org/content/10.1101/…
Thread👇 – with movie!!
Malte Gersch retweeted
We started collecting applications for SciFounder Fellowship!!
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Malte Gersch retweeted
Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.
biorxiv.org/content/10.1101/…
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s41589-0…
For all ubiquitin, deubiquitinase and chemical biology aficionados:
Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains.
t.ly/GnRVv
Thread👇(1/10)
Malte Gersch retweeted
Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸
➡️ cell.com/cell/fulltext/S0092…
Malte Gersch retweeted
Excited to share this work led by @CamillaElb
where we identify an entirely new role of LUBAC as a critical regulator of AMPK, the energetic stress response, and cellular metabolism. If you are interested in #ubiquitin and #metabolism, have a read: biorxiv.org/content/10.1101/…
Malte Gersch retweeted
Thanks very much, @MalteGersch, for inviting me to the @mpimoph. I had a great time in Dortmund!
Malte Gersch retweeted
Enjoying the #EMBOubiquitin2024 meeting in beautiful, sunny Cavtat with this lot @jnpruneda @Elliott_Lab_Ox @MalteGersch @YKulathu
Malte Gersch retweeted
Applications are welcome, please share 📢
Guess how protein quality control, innate immune signaling and host-pathogen interactions are connected? It is via linear ubiquitin chains! Want to learn more? Apply for the project offered by @winklhofer_lab @IMPRS_LM. #IMPRS #PhDposition #proteostasis #linearUb
This study is the result of persistent work and heroic efforts by Nafizul Kazi (on the far left in the picture). Chemistry by @NikolasKlink, cellular assays by @gallant_kai and Gian. Thank you for support by @mpimoph, @TU_Dortmund, @IMPRS_LM, @crc1430 .
