Los Angeles, CA
Joined June 2011
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Ecstatic to share the first story from my post-doc, co-led with Megan Ostrowski, out now in final form (cell.com/cell/fulltext/S0092…)!
Marty Yang retweeted
Now online! The single-molecule accessibility landscape of newly replicated mammalian chromatin dlvr.it/TGSdZs
Marty Yang retweeted
Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s41586-0…
We are excited about future applications of RASAM to better define the regulatory logic that underlies chromatin maturation across different cellular contexts.
Marty Yang retweeted
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro biorxiv.org/cgi/content/shor… #biorxiv_devbio
Marty Yang retweeted
Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development. shorturl.at/9w0zT
Marty Yang retweeted
Excited to present my first large piece of work of my PhD: ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers. biorxiv.org/content/10.1101/…
Thank you to everyone in the Narlikar/Ramani labs who made it possible!
1/n
Marty Yang retweeted
Grateful for the chance to sit down with @sharilwiseman @NatureNeuro to discuss my lab’s work on glia and some of the challenges I’ve faced as a trans and indigenous person on the path to a career in academic science.
We spoke with Lucas Cheadle (@LucasCheadle) about his passion for studying glia and synapses, and about his experiences as an Indigenous and transgender neuroscientist (2/5)
nature.com/articles/s41593-0…
Marty Yang retweeted
Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation.
biorxiv.org/content/10.1101/…
Marty Yang retweeted
Gladstone Investigator Vijay Ramani (@vram142) and collaborator Siva Kasinathan (@SivaKasinathan) led a study that demonstrates how two new tools can perform single-cell genetic sequencing using less DNA than required by today’s gold-standard methods.
bit.ly/4bIUD0Z
Marty Yang retweeted
exciting new techniques from @vram142's lab! Adaptations of SMRT and SAMOSA with tagmentation for much lower input material for the former, and addition of chromatin accessibility for the latter. nature.com/articles/s41588-0…
Marty Yang retweeted
Neurons and astrocytes closely coordinate their gene expression, in a program we call “SNAP” – a collaboration that we find to be central in protection from schizophrenia and cognitive aging.
nature.com/articles/s41586-0…
Marty Yang retweeted
Check out this video interview with postdoc Marty Yang. Yang shares what brought him to Gladstone, his future career goals, and his passion for mentoring.
bit.ly/46D8XoF
Very excited to share our latest @vram142 lab preprint on developing methods for long-read footprinting of protein-DNA contacts in newly replicated chromatin fibers, co-led with Megan Ostrowski. biorxiv.org/content/10.1101/… (1/x)
Meanwhile, at highly transcribed TSSs, we observe that high levels of chromatin accessibility are retained and/or rapidly restored within minutes of fork passage, suggesting that nucleosome-free regions are tightly coordinated with the replisome. (12/x)
