@NIH_ORIP

Official account of NIH’s Office of Research Infrastructure Programs. Infrastructure for Innovation. Privacy: https://xitter.cf/t.co/buU8pnWbOY engagement ≠ endorsement

 Bethesda, MD
orip.nih.gov
Joined July 2016
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811Media
Because of a lapse in government funding, new posts and responses will not originate from this account until appropriations are enacted.
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Mark your calendars 🗓️ORIP’s #Cryopreservation workshop continues: Session V: Long-Term Preservation Methods for Nonhuman Primate Models in Biomedical Research takes place on July 15, 2025, from 12pm-5pm EDT. Learn more below and register today: scgcorp.com/Cryopreservation… @NIHAging
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👨‍🔬In this #ResearchHighlight: The Center for Precision Medicine Models, at @bcmhouston, is developing animal models that can be used to end the diagnostic odyssey for patients with #rarediseases. (ORIP- U54OD030165) Learn more about CPMM: orip.nih.gov/about-orip/rese….
Visualization of UBA5 expression in the adult fly brain. Image courtesy of Dr. Jason Heaney, Baylor College of Medicine.

ALT Visualization of UBA5 expression in the adult fly brain. Image courtesy of Dr. Jason Heaney, Baylor College of Medicine.

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😍A placental #GeneTherapy approach to boosting the placenta is safe in monkeys, according to a new pilot study, which may bring treatment closer to improving birthweights of human babies. Wilson et al. (ORIP-P51OD11106, S10OD023526) pubmed.ncbi.nlm.nih.gov/3949…
Yellow coloring in this microscope image is the mark of successful delivery of gene therapy via nanoparticles into placental cells from monkeys (each marked by blue-colored nuclei) and expression of a gene expected to boost the fetus-nourishing health of the placenta.

ALT Yellow coloring in this microscope image is the mark of successful delivery of gene therapy via nanoparticles into placental cells from monkeys (each marked by blue-colored nuclei) and expression of a gene expected to boost the fetus-nourishing health of the placenta.

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🔍Scientists identify extended survival of 9- and 10- #Gene edited #Pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression. Chaban et al., J Heart Lung Transplant, 2024. @CAFNRNews (ORIP- U42OD011140) pubmed.ncbi.nlm.nih.gov/3909…
Xenograft survival, function, and hypertrophy + animal weight + aCD154.

ALT Xenograft survival, function, and hypertrophy + animal weight + aCD154.

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Our new perspective article describing the human and non-human primate developmental GTEx projects is now out in @Nature! We outline the scope, vision, opportunities and challenges of these projects here: nature.com/articles/s41586-0…

The human and non-human primate developmental GTEx projects

Nature - The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood...

nature.com
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😍In this study, scientists report the single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants. Liu et al., Nat Commun., 2024. (ORIP support through K01OD026529) pmc.ncbi.nlm.nih.gov/article…
Protection of CDO-7N-1 immunized mice against infection with the Beta, Delta and Omicron SARS-CoV-2 variants of interest (VOI).

ALT Protection of CDO-7N-1 immunized mice against infection with the Beta, Delta and Omicron SARS-CoV-2 variants of interest (VOI).

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Dr. Victoria Baxter, D.V.M., Ph.D., co-author of the study and @txbiomed assistant professor, was supported by a SERCA K01 career development award. txbiomed.org/scientists/vict…

Victoria Baxter, D.V.M., DACLAM, Ph.D. - Texas Biomed

Baxter examines the pathogenesis of and host immune response to emerging infectious diseases, particularly encephalitic arboviruses.

txbiomed.org
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⚙️#ORIPResourceOfTheMonth. The National Xenopus Resource, @XenopusNXR collaborates with @ExrcXenopus, supporting the Xenopus community by providing breeding, maintaining genetic stocks & distributing stocks to researchers. (ORIP- P40OD010997). Learn more: orip.nih.gov/division-compar…
Xenopus.

ALT Xenopus.

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📢Join #ORIP for a special 2-hour webinar on February 11 from 1:00 to 3:00 PM (EST) to learn about the changes and key elements in an S10 application as well as expert reviewer’s perspectives on writing a successful S10 application. #GrantTips #S10Grant scgcorp.com/PreApplicationS1…
Pre-Application Webinar for an S10 Grant.

ALT Pre-Application Webinar for an S10 Grant.

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📌We will also have time to address questions. See the full agenda here: scgcorp.com/PreApplicationS1…
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🎯Don’t miss your chance to register. You can save your spot here scgcorp.zoom.us/webinar/regi… #InfrastructureforInnovation #NIHGrants
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🧑‍🔬Dive into this study describing the establishment and characterization of three new cell lines, derived from human ocular adnexal sebaceous carcinoma, to serve as models for #DrugDevelopment. Lee et al., Int J Mol Sci., 2024. (ORIP-K01OD034451) pmc.ncbi.nlm.nih.gov/article…
Analysis of sebaceous carcinoma cell growth and differentiation.

ALT Analysis of sebaceous carcinoma cell growth and differentiation.

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Mark your calendars🐵Session V of the #cryopreservation workshop will take place on Feb. 7 from 12:00 p.m.–5:00 p.m. EST. This workshop will discuss long-term preservation methods for nonhuman primate models in #BiomedicalResearch. 👉Register today: scgcorp.com/Cryopreservation…
Cryopreservation and Other Preservation Approaches for Animal Models. September 2024-February 2025.

ALT Cryopreservation and Other Preservation Approaches for Animal Models. September 2024-February 2025.

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👉READ: “Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy.” Wang et al., PNAS, 2024. @NIH_NINDS @ColumbiaMed (ORIP support through U54OD030187, U54OD020351, S10OD026974) pubmed.ncbi.nlm.nih.gov/3937…
TEM images show AIS structural changes caused protein aggregation in Arhgef9G55A/Y neurons.

ALT TEM images show AIS structural changes caused protein aggregation in Arhgef9G55A/Y neurons.

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Findings reveal short-term exposure to proinflammatory cytokines leads to diminished tight junction in canine intestinal organoids. Nakazawa et al., In Vitro Cell Dev Biol Anim., 2024. @WSUvetmed (ORIP- K01OD030515, R21OD031903) 👉 Learn more: pmc.ncbi.nlm.nih.gov/article…
Impact of proinflammatory cytokine exposure on cell proliferation dynamics.

ALT Impact of proinflammatory cytokine exposure on cell proliferation dynamics.

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✅READ: “A Comparative Review of Cytokines and Cytokine Targeting in Sepsis: From Humans to Horses.” Hobbs et al., Cells, 2024. @NCStateVetMed (ORIP support through T32OD011130) pmc.ncbi.nlm.nih.gov/article…
Shared pathology between humans and horses during insult from endotoxins or exotoxins during sepsis. This insult results in the production of PAMPS, DAMPS, and cytokines, leading to downstream effects such as cell death, organ failure, coagulopathies, and host death in both species.

ALT Shared pathology between humans and horses during insult from endotoxins or exotoxins during sepsis. This insult results in the production of PAMPS, DAMPS, and cytokines, leading to downstream effects such as cell death, organ failure, coagulopathies, and host death in both species.

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👀Researchers successfully reduced viremia in a highly pathogenic model of HIV in rhesus macaques, providing proof of concept for a new class of single-administration antiviral therapies. Pitchai et al., @theNCI (ORIP- P51OD011092, U42OD010426) pubmed.ncbi.nlm.nih.gov/3911…
A single-dose HIV therapy: TIPs reduce disease in nonhuman primates through conditional replication.

ALT A single-dose HIV therapy: TIPs reduce disease in nonhuman primates through conditional replication.

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🧐READ: “Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.” Phan et al., @NIAIDnews, @LosAlamosNatLab, @PSUScience (ORIP support through R01OD011095) pubmed.ncbi.nlm.nih.gov/3874…
Green 762 indicates PTC. Dark orange indicates NC. The horizontal dashed line is the limit of detection. 763 Open circles are data points below the limit of detection (50 viral RNA copies/mL). Filled circles 764 are data points above the limit of detection.

ALT Green 762 indicates PTC. Dark orange indicates NC. The horizontal dashed line is the limit of detection. 763 Open circles are data points below the limit of detection (50 viral RNA copies/mL). Filled circles 764 are data points above the limit of detection.

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