physician • scientist • writer • educator @ uiowa eye + institute for vision research || duke | wilmer | iowa
Iowa, USA
Joined September 2019
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A solar eclipse, viewed unsafely, can result in vision loss (solar retinopathy).
But did you know an eclipse nearly 80 years ago (during WWII) inspired the lasers used in #ophthalmology?
I had the chance to share that amazing story this week @uiowaeye morning rounds.
1/🧵
Look out for “SOPLA” in cases of unexplained vision loss👇
Congrats to Dr. Boyce, the diligent clinician scientist shown below, as esteemed first author.
We had many lab meetings over several years to put this paper together.
He sorted out the science…I balanced lenses 🤣
SPLIT OUTER PLEXIFORM LAYER APPEARANCE REPRESENTS AN ACQUIRED CONE DYSFUNCTION PHENOTYPE OF AUTOIMMUNE RETINOPATHY
Boyce, Timothy M. MD; et. al.
Retina 45(3):p 522-531, March 2025
journals.lww.com/retinajourn…
#retina
As learners, we walk in the shoes of those who have gone before. In doing so, we learn the way.
Congrats to retina fellows Dr. Bhuyan and Dr. Jamshidi on tremendous growth @uiowaeye.
They were thrilled to get custom colored FlyEase OR shoes for the next steps of their journey!
Ian Han, MD retweeted
Very happy to share our study of human photoreceptor cell development finally out today in @jclinicalinvest! The cover image is an example of the sort of retinal organoids we used to model the inherited disease caused by NR2E3 variants. Check out those photoreceptors!!
#Cover: Human organoid models of retinal #development: buff.ly/3VoKL6I
#Image: Scanning electron micrograph of mature human retinal organoid derived from a patient with NR2E3-associated enhanced S-cone syndrome;#Credit:Arwin Shrestha
@StemCellsEh @IowaMed
#Ophthalmology
Resident and Fellow Research Day is the “most important day on our academic calendar” @uiowaeye.
Congratulations to all the trainees and their faculty mentors for fantastic presentations today.
It was a great day celebrating our dedication to progress in #ophthalmology!
ARVO’s annual meeting is not only the largest vision research gathering in the world — but also a yearly reminder that science advances through relationships as much as experiments.
Great to see such progress in the field and to share smiles, enthusiasm, and ideas. #ARVO2024
Lots of great work to share and discuss. ARVO has had a great hum of energy so far.
Come by our posters and talks to say hi!
webeye.ophth.uiowa.edu/updat…
We can't wait to see everyone at #ARVO2024! Be sure to say hello 👋 and check out the vision research 👁️ taking place at @uiowa: bit.ly/4bpLcmA
I’ve come out of Twitter/X hibernation to say the following:
Bilal cares about making the world better for others. We are lucky to have him as a resident at Iowa.
(This podcast is just me rambling.)
New episode of The Resident Journey with Dr. Ian Han (@3Y3MD) on tips for transioning as a senior resident and retinal imaging interpretation.
spotify.link/XTfqruEwqIb
Ian Han, MD retweeted
New case now on Eyerounds!
Acute syphilitic posterior placoid chorioretinitis can be a rare manifestation of ocular syphilis. What characteristic pattern can be found on FA?
Find the answer here: eyerounds.org/cases/346-ASPP…
@LeeGrace_05
@honestlybilal
@highhopemyope
Great job by @uiowaeye resident @agarzareyes on this imaging report about a very peculiar OPL appearance in Wolfram (DIDMOAD) syndrome.
To learn more, check out a nice multicenter case series in @AAOjournal by @pearsekeane @MichelMichaelid and colleagues:
pubmed.ncbi.nlm.nih.gov/2687…
A very peculiar outer plexiform layer can be seen in autosomal dominant Wolfram syndrome. Recognizing this OCT appearance may help guide diagnosis and molecular testing in this rare condition. @3Y3MD; @agarzareyes ow.ly/SQRK50OPSEy
Thanks @NEIDirector for the mention 🙏
Our team’s current AAV paradigm:
1) Human explants/organoids for tropism+transduction
liebertpub.com/doi/10.1089/h…
2) Confirm tropism in animal models+ensure no toxicity
liebertpub.com/doi/10.1089/h…
3) Assess inflammation to choose vector+route ⬇️
Limiting ocular inflammation is a challenge in gene therapy delivery. This #NEIfunded research finds AAV serotype and delivery routes mediate the degree of inflammation.
@3Y3MD @ChoroidLab @StemCellsEh @IowaMed @uiowaeye
@LiebertPub paper: bit.ly/3Nop6pZ
ALT Illustration shows how gene therapy using an adenovirus vector works. A new gene is inserted directly into a cell. A carrier called a vector is genetically engineered to deliver the gene. An adenovirus introduces the DNA into the nucleus of the cell, but the DNA is not integrated into a chromosome. Credit: U.S. National Library
Artificial intelligence vs. actual intelligence?
Thoughts on ChatGPT vs. my genius first grade daughter in this month’s @OphthTimes 👀 editorial:
“Retinator III: Rise of the (Writing) Machines.”
Scribo, ergo sum!
Fear not, my fellow humans. Our future is safe! #ophthotwitter
Start a brewery in the middle of the pandemic and make a special IPA to raise awareness and funds for vision research?
Sure thing! Thanks to “courage” and the “power of the human spirit.”
Thanks to @BlindButcherBru + @BackpocketBrew for supporting our mission to cure blindness!
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Proud to work with this retina crew @uiowaeye.
Medicine is a long road. Celebrate the moments, big and small.
Best part of this tradition is listening to each others' life stories.
@cytheeyeguy and @drdotson have absolutely incredible stories and are so important in our field.
Thanks to open source data from Christine Curcio’s (@AMD_histo_lab) landmark 1990 photoreceptor topography paper…
We can use modern computational methods to model #retina cell loss by OCT.
nature.com/articles/s41598-0… 👀
Beautiful work by the brilliant @sswhitmore + RIM Lab team!
Also check out @sswhitmore’s super cool OCT simulator to estimate the proportion of rod and cone loss.
Severe loss is obvious, but partial loss can be tough to appreciate qualitatively.
The simulator provides a nice visualization to train your 👁️!
observablehq.com/@barefootbi…
Today was Douglas Jin’s last day on my rotation for retina fellowship. One last Saturday session after postops for one-on-one surgical teaching (with all my scribbles).
So great to see Dr. Jin’s growth. He will be serving the Seattle area well in a few months!
📸: Dr. Binkley
Huge highlight of #ARVO2023 was Budd Tucker’s amazing Cogan Award lecture.
Such a sweeping tour of the landscape of gene and cell replacement therapy — and a testament to the power of team science.
Thanks to @StemCellsEh for your friendship. Constantly inspired by your passion.
Every ARVO, I’m reminded that science advances through relationships as much as experiments.
#ARVO2023 has been full of smiles and positive energy toward progress in #ophthalmology.
Grateful to have such colleagues and friends in our field.
ARVO is “Our-VO”!
Every ARVO, I’m reminded that science advances through relationships as much as experiments.
#ARVO2023 has been full of smiles and positive energy toward progress in #ophthalmology.
Grateful to have such colleagues and friends in our field.
ARVO is “Our-VO”!
Ian Han, MD retweeted
Super impressed by the great science being presented at #ARVO2023! For any scientists working on retinal neuroprotection, neuroenhancement, or regeneration, please keep this special issue of Ophthalmology Science in mind for submission. Pub fees waived!
Ian Han, MD retweeted
Heading to @ARVOinfo #ARVO2023!Let’s meet up and talk vision science!!!Proud to be a part of this amazing @uiowaeye team! Come say hi to the Hawkeyes! shorturl.at/EHIP8
