
Interventional Cardiologist @SanRaffaeleMI Fellow @cliniquepasteur | #EAPCI Accreditation, Training and Certification Committee | FESC @escardio
Milano, Lombardia
Joined April 2019
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#PCRLV 2024 is just around the corner!
Be part of this year’s brand new simulation-based #learning program on #RedoTAVI
Join us in London! 🇬🇧🤖❤️
@DrArifK @myriam_akodad Vinnie Bapat @David_Meier_ @ignamatsant @fra_giannini1 @nbuzzatti @dmylotte #TAVI #TAVR
Alessandro Beneduce retweeted
My #interventionalcardiology Toolkit 🧰⚙️🪛 No-reflow: distal drug delivery with standard #PCI equipment
🔗pcronline.com/Cases-resource…
No-reflow is one of the most critical peri-procedural complications and the development of no-reflow can rapidly trigger cardiogenic shock. Emrullah Kiziltunc, Ender Ornek, Adnan Abaci and Mustafa Cetin from 🇹🇷 provide a step-by-step methodology to manage this situation.
Reviewed by Manel Sabate.
.
#CardioEd #Cathlab
@kiadeb87 @fjsawaya @sbrugaletta
Alessandro Beneduce retweeted
Join @AnasNomanMD @AdamGreenbaumMD & crew @TCT_ME_ for a workshop on this procedure👇
Registration tctplusme.com/register
First transcaval TAVR for our structural team in Toledo, OH. Always something to learn from electrosurgical procedures.
In a severely calcified descending aorta, transcaval is still feasible if you have a window 5-6mm in diameter. Closure may not achieve a complete seal however, since the ADO disc might not fully appose calcified nodules. A mild residual fistula is okay and will likely seal over time.
@6ayyeboon @AlkashkariWail @mirvatalasnag @amrmohsen213 @BinAbdulHak_A @MarwanSaadMD @aelsab @MusaSharkawi @djc795 @MohammedQintar @mhammadah @AdamGreenbaumMD @AlhijjiM @EmoryUniversity @JDDCFratti @acamajmd @crfheart @djc795 @mmamas1973 @TCT_ME_ @crfheart @BakhshiHooman @Almanfi_Cardio @Dr_ibrahimHarbi @scottiejj12
Alessandro Beneduce retweeted
Protruding aorto-ostial stents can preclude safe TAVR. The RASE technique, integrating reverse hairpin re-entry, intentional fracture & snare extraction, offers a out-of-the-box controlled solution.
Honored to contribute to this work in @JACCJournals Case Reports with @RaghavG_MD et al.
doi.org/10.1016/j.jaccas.202…
Alessandro Beneduce retweeted
Replying to @gbiondizoccai @JACCJournals
This is one of the most impactful mechanistic papers in advanced structural heart in 2026
And it’s not just about leaflet modification, second implant type and position affects functional splay area with implication on sinus flow and re-re-do ViV
@ABeneduceMD @KKoulogiannis @PhilGenereuxMD @PedroMDMSc
Alessandro Beneduce retweeted
BASILICA and BA-BASILICA create similar sized vertical splays in the leaflet neoskirt for TAV-in-TAV, whereas UNICORN generates larger functional splay areas but only when intraleaflet deployment is feasible jacc.org/doi/10.1016/j.jcin.… @JACCJournals
Alessandro Beneduce retweeted
Few things in Medicine are more elegant than ultrasound guided vascular access. I’m embarrassed it took me too long to adopt it.
🫀 #EHRAtopicweek | Vascular access in EP
Landmarks alone can deceive you. At lower inguinal punctures, the femoral vein sits posterior to the artery (>50% overlap) in ~24% of cases — and fully lateral in 6%. That's why palpation-guided access carries a real AV-fistula risk.
The fix? Ultrasound-guided access. Better success, fewer complications, especially in difficult or previously failed cases.
Know the anatomy. Image the vessel. Puncture with confidence. 🎯
Read more 👉 bit.ly/4eTAp7w
@escardio #EHRA_ESC
Alessandro Beneduce retweeted
Great. So everything I taught my students about heart failure this year is officially obsolete. Just when I’d mastered saying HFrEF, HFmrEF, and HFpEF without spraining my tongue, here comes the next wave: Pre-HF, remHF, recHF, impHF. Looking forward to HFxyz next year. ahajournals.org/doi/10.1161/…
Alessandro Beneduce retweeted
#TAVI is no longer just about procedural success.
As indications expand, heart teams must increasingly anticipate coronary access, valve durability, redo interventions, and lifetime management.
Explore The Essentials of TAVI, led by Ole De Backer, Christian Frerker and Alper Öner:
pcronline.com/Cases-resource…
This special report on TAVI is available thanks to the support of @AbbottCardio.
PCR develops independent educational content.
#StructuralHeart #InterventionalCardiology #CardioEd #CardioTwitter
Alessandro Beneduce retweeted
Leaflet modification showed high technical feasibility but notable early clinical risk, supporting its use as an adjunctive strategy in carefully selected #TAVR patients. jacc.org/doi/10.1016/j.jcin.…
#JACCINT @drgocchipinti @LaudaniClaudio @AnderRegueiro
Alessandro Beneduce retweeted
BATMAN was associated with high technical success and effectiveness in preventing #LVOT obstruction and appeared to be safe in ViR and ViV procedures. Adverse events were higher in ViMAC. jacc.org/doi/10.1016/j.jcin.… #JACCINT #TMVR
Alessandro Beneduce retweeted
Welcome to our JUNE 24 issue of #JACCCaseReports @JACCJournals
jacc.org/journal/case-report… with a mini-focus on leaflet modification to coincide with the #JACCINT special issue and to celebrate the 10-year anniversary of leaflet modification (LAMPOON). We are also promoting a mini-focus issue on valvular heart disease to coincide #NYValves2026.
Thank you @CraigBasman @TagliariPaula @KarlPoonMD for authoring the Editor’s Page:
Valvular Heart Disease: From Guidelines to the Bedside
jacc.org/doi/10.1016/j.jacca…
Full PDF here:
jacc.org/doi/10.1016/S2666-0…
@minnowwalsh
@hmkyale
@Justine_Turco
LEAFLET MODIFICATION
Transcatheter Electrosurgery for Coronary Access After TAVI-in-TAVI
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Innovative Electrosurgery Application in the Era of TAVR-in-TAVR: A Step Forward in Regaining Coronary Access
jacc.org/doi/10.1016/j.jacca…
UNICORN TAVR in Native Complex Congenital Aortic Stenosis at High Risk of Coronary Obstruction
jacc.org/doi/10.1016/j.jacca…
Novel Use of Radiofrequency Guidewire in Leaflet Modification: The BABICORN and ROBIN Procedures
jacc.org/doi/10.1016/j.jacca…
Double LLAMACORN: Bilateral Leaflet Modification Technique to Prevent Coronary Obstruction
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Variations and Evolution in Balloon-Based Leaflet Modification: Ensuring Procedural Success
jacc.org/doi/10.1016/j.jacca…
Balloon-Assisted Leaflet Laceration Using Modified UNICORN Technique in Native Valve TAVR
jacc.org/doi/10.1016/j.jacca…
Simplified UNICORN for Transcatheter Aortic Valve Replacement
jacc.org/doi/10.1016/j.jacca…
First Report of Anchoring Via Trans-Leaflet Apposition Stent (ATLAS): Leaflet Modification for Failing Noncalcified Valves
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Securing the Anchor in Pure Native Aortic Regurgitation: Innovations, Techniques, or Dedicated Devices?
jacc.org/doi/10.1016/j.jacca…
Transcatheter Mitral Valve-in-Valve Replacement: Overcoming an Obstacle Race
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Expanding the Toolbox for Mitral Valve-in-Valve Therapy: Innovation Demands Evidence
jacc.org/doi/10.1016/j.jacca…
VALVULAR HEART DISEASE
Robotic Mitral Valve Repair With Severe Pectus Excavatum
jacc.org/doi/10.1016/j.jacca…
Aortic Valve Neocuspidization in Libman-Sacks Endocarditis
jacc.org/doi/10.1016/j.jacca…
Temporary Mechanical Support as a Bridge to Transcatheter Aortic Valve Replacement in Cardiogenic Shock
jacc.org/doi/10.1016/j.jacca…
Tricuspid Transcatheter Edge-to-Edge Repair in Orthotopic Heart Transplantation Recipients
jacc.org/doi/10.1016/j.jacca…
Frozen Leaflet During Transcatheter Balloon-Expandable Aortic Valve Implantation: Early Recognition and Safe Management
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Intraprocedural Leaflet Dysfunction and the Importance of Device Planning in Contemporary Transcatheter Aortic Valve Replacements
jacc.org/doi/10.1016/j.jacca…
Transcatheter Edge-To-Edge Repair After Patent Foramen Ovale and Atrial Septal Defect Closure
jacc.org/doi/10.1016/j.jacca…
Transcatheter Edge-to-Edge Repair in a Patient With Severe Degenerative Mitral Regurgitation and Mirror-Image Dextrocardia
jacc.org/doi/10.1016/j.jacca…
Mitral Edge-to-Edge Repair Resolves Hemolytic Anemia After Surgical Mitral Valve Repair
jacc.org/doi/10.1016/j.jacca…
Valve-in-Valve Transcatheter Aortic Valve Replacement After a Valve-in-Valve Transcatheter Mitral Valve Replacement
jacc.org/doi/10.1016/j.jacca…
Unprecedented Complication of Left Bundle Branch Pacing: Ventricular Septal Defect With Mitral Valve Injury
jacc.org/doi/10.1016/j.jacca…
Combined Snare and Buddy-Balloon Strategy for Failed Valve Crossing in Valve-in-Valve Transcatheter Aortic Valve Replacement
jacc.org/doi/10.1016/j.jacca…
Aortic Root Abscess With Left Atrial Fistula: A Rare and Life-Threatening Complication of Infective Endocarditis
jacc.org/doi/10.1016/j.jacca…
Platypnea-Orthodeoxia After TAVI for Severe Aortic Regurgitation: A Breathless Surprise
jacc.org/doi/10.1016/j.jacca…
Long-Term Follow-Up After Dual Transcatheter Valve-in-Valve Implantation Under VA-ECMO Support
jacc.org/doi/10.1016/j.jacca…
Recurrence of Prosthetic Aortic Valve Endocarditis After Percutaneous Mechanical Aspiration
jacc.org/doi/10.1016/j.jacca…
4-Dimensional Intracardiac Echocardiography-Guided Antegrade TAVR Using a Novel CABLE-TAVR Technique
jacc.org/doi/10.1016/j.jacca…
Delayed Repair of an Iatrogenic Perimembranous VSD After Redo Aortic Valve Replacement: Timing Over Urgency
jacc.org/doi/10.1016/j.jacca…
Infective Endocarditis Mimicking Reactive Arthritis: A Diagnostic Detour
Recurrent Prosthetic Valve Endocarditis With Aortomitral Curtain Destruction in an Elderly Patient
jacc.org/doi/10.1016/j.jacca…
Dedicated Transcatheter Valve for Pure Aortic Regurgitation in a Failed Stentless Bioprosthesis
jacc.org/doi/10.1016/j.jacca…
Protected Mitral TEER With Temporary Ventricular Circulatory Support in Severe Left Ventricular Dysfunction for Heart Failure Management
jacc.org/doi/10.1016/j.jacca…
Editorial Comment
Mitral Transcatheter Edge-to-Edge Repair in Severe Left Ventricular Dysfunction: Beyond Procedural Success
jacc.org/doi/10.1016/j.jacca…
Organizing Hematoma Involving a Native Tricuspid Valve: Fatal Case of Cardiac Behçet Disease–Hughes-Stovin Syndrome Overlap
jacc.org/doi/10.1016/j.jacca…
Endocarditis Masquerading As Malignancy: Native Valve HACEK Infection
jacc.org/doi/10.1016/j.jacca…
High-Risk Valve-in-Valve TAVR With Chronic Type B Aortic Dissection
jacc.org/doi/10.1016/j.jacca…
Severe Calcific Bicuspid Aortic Valve Stenosis Presenting as Reversible Complete Heart Block
jacc.org/doi/10.1016/j.jacca…
Prosthetic Aortic Valve Vegetation: A Percutaneous Mechanical Aspiration Approach
jacc.org/doi/10.1016/j.jacca…
Heyde Syndrome in Moderate Bioprosthetic Aortic Valve Stenosis: A Twist in the Valve
jacc.org/doi/10.1016/j.jacca…
TAVR in a Small Surgical Bioprosthesis With a Kinked Aortic Graft Using an Intra-Annular Self-Expanding Valve
jacc.org/doi/10.1016/j.jacca…
Step-by-Step Femoral–Femoral Percutaneous Mechanical Aspiration Debulking of Anterior Tricuspid Valve Vegetation
jacc.org/doi/10.1016/j.jacca…
Transcatheter Aortic Valve Replacement in Aortic Regurgitation Secondary to Aortic Valvulitis
jacc.org/doi/10.1016/j.jacca…
Redo Transcatheter Aortic Valve Replacement for Degenerated Valve With High-Risk Coronary Anatomy
jacc.org/doi/10.1016/j.jacca…
Mitral Valve Endocarditis by Micrococcus luteus: First European Case
jacc.org/doi/10.1016/j.jacca…
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@MarcEngels7
@Miho_Fukui_
@ErikaHuttce
@Nishaki1
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Alessandro Beneduce retweeted
This bench study defines optimal balloon sizing for UNICORN across common #THV platforms and confirms coronary clearance. It was determined that one index valve resisted intraleaflet deployment. Further clinical validation is required jacc.org/doi/10.1016/j.jcin.… #JACCINT #TAVR
Alessandro Beneduce retweeted
Proud to have helped curate the 2-part landmark special issue on LEAFLET MODIFICATION (LM) in #JACCINT @JACCJournals with Editor-in-Chief David Moliterno and Vasilis Babaliaros to celebrate the 10-anniversary of the 1st leaflet modification done in the world (LAMPOON)! Grateful to be a senior author and co-author of several papers.
jacc.org/toc/interventions/1…
jacc.org/toc/interventions/1…
Congrats to all the authors from around the world who have contributed to this seminal effort!
Key highlights:
Leaflet modification algorithms:
jacc.org/doi/full/10.1016/j.…
AORTIC Leaflet Modification
BASILICA step-by-step review:
jacc.org/doi/full/10.1016/j.…
UNICORN step-by-step review:
jacc.org/doi/full/10.1016/j.…
"Split-line" Concept in LM in Redo-TAVR:
jacc.org/doi/full/10.1016/j.…
UNICORN benchtop validation in redo-TAVR: works better with failed Sapien, Evolut, Acurate than Navitor:
jacc.org/doi/full/10.1016/j.…
UNICORN registry:
jacc.org/doi/full/10.1016/j.…
Bench testing showing UNICORN more effective than (BA)BASILICA in Redo-TAVR:
jacc.org/doi/full/10.1016/j.…
Bench testing showing LM in redo-TAVR dependent on TAV type, constraint, 2nd TAV implant. BASILICA no effect on Navitor and BA-BASILICA better with failed Evolut + Acurate
jacc.org/doi/full/10.1016/j.…
HALT reduction with leaflet modification in VIV #TAVR:
jacc.org/doi/full/10.1016/j.…
Bench testing on LM of calcified native and SAV leaflets showed higher Ca burden increased laceration difficulty, leaflet tears and embolic debris; less spray with shorter leaflet length
jacc.org/doi/full/10.1016/j.…
LOFTER-TAVR registry:
jacc.org/doi/full/10.1016/j.…
CT simulation of LM impact on Redo-TAVR Feasibility:
jacc.org/doi/full/10.1016/j.…
Fluoro Left-Main Frame Alignment View to Evaluate coronary obstruction in redo-TAVR:
jacc.org/doi/full/10.1016/j.…
FIH wire anchoring-assisted BASILICA/UNICORN:
jacc.org/doi/full/10.1016/j.…
FIH tricupsidization of bicuspid native #TAVR
jacc.org/doi/full/10.1016/j.…
Mitral Leaflet Modification
LAMPOON/BATMAN step-by-step:
jacc.org/doi/full/10.1016/j.…
BATMAN registry
jacc.org/doi/full/10.1016/j.…
TRICUSPID Leaflet Modification
ELASTA-T for failed T-TEER to facilitate TTVR step-by-step:
jacc.org/doi/full/10.1016/j.…
Mechanisms of failed BASILICA/LAMPOON/SEASAME:
jacc.org/doi/full/10.1016/j.…
Alessandro Beneduce retweeted
This year I am particularly pleased, because confirmations are harder than breakthroughs, and this result covers a two-year period in which we had no tailwind from guidelines. It is a genuine expression of where EuroIntervention stands today in the broader landscape — as reflected also by the 5-year impact factor, which has been growing for several years now and is a more reliable indicator of trajectory than any single data point.
Other technical metrics I follow closely, because they tell a richer story than the impact factor alone and weigh heavily on authors' choices, are the quartile (Q1), the percentile (91.4), the cited half-life of articles (5.3 years — notably long), the proportion of open-access articles (3.15% — very low, which authors tend to favour but which limits accessibility and possibly citability), and the self-citation rate (negligible, because it is something we have never actively managed).
So: 9.2 is entirely ours, and it is the result of the work of so many people that I would not know where to begin. Thank you.
📢 The 2025 Impact Factor is here!
We're pleased to share that EuroIntervention has achieved a 2025 Impact Factor of 9.2.
The journal is now ranked #21 out of 237 cardiology journals, maintaining its position in the top quartile of the field.
A huge thank you to our authors, reviewers, editorial board members and readers for their continued support and contributions.
#ImpactFactor #CardioEd #InterventionalCardiology @PCRonline
Alessandro Beneduce retweeted
This week, a team of researchers quietly published in @JACCJournals one of the most profound studies of valvular heart disease in recent memory.
The PREVUE-VALVE study used a decentralized, in-home echocardiography model to estimate the prevalence of valvular heart disease among U.S. adults aged 65–85. Importantly, this was not a clinic-based echo cohort; participants were recruited nationally and underwent comprehensive transthoracic echo in their homes, with studies interpreted by a core lab. That intentional design choice is critical: PREVUE-VALVE is a true prevalence study, accurately representing the true burden of valve disease in the U.S. population.
The findings are striking: 8.2% of older Americans have moderate or greater valvular heart disease, and 18.4% have “clinically significant” disease when mild-to-moderate regurgitation is included. TR was the most common lesion, followed by AS, MR, AR, and MS. The burden rises sharply with age, reaching nearly 15% among adults aged 80–85.
Extrapolated nationally, this means approximately 4.7 million Americans aged 65–85 currently have moderate or greater VHD, projected to increase to 6.5 million by 2060. Using the broader clinically significant definition, the number is already over 10 million and projected to approach 15 million.
For structural heart programs, health systems, and policymakers, the message is clear: the valve disease burden is large, growing, and will require thoughtful planning around screening, access, and treatment capacity.
Congratulations to @djc795, Michael 'Mickey' Brener MD MS, and all co-authors for a stunning glimpse into the present and future of valve disease!
jacc.org/doi/epdf/10.1016/j.…
Alessandro Beneduce retweeted
Transcatheter papillary muscle approximation (or "percutaneous papillary muscle banding") targets left ventricular geometry rather than contractility. A 58-year-old man with advanced ischaemic heart failure and a severely dilated, spherical left ventricle due to adverse remodelling underwent first-in-human implantation using the VSling system. Via transfemoral access, a steerable catheter encircled both papillary muscles and deployed an adjustable band, reducing interpapillary distance from 27 to 12 mm. eurointervention.pcronline.c…
Alessandro Beneduce retweeted
Can chimney stenting reliably protect the coronaries during redo-TAVI?
Using patient-specific models, this study highlighted how valve design, commissural alignment, and implant depth may influence stent integrity and the feasibility of future coronary access.
eurointervention.pcronline.c…
@ABeneduceMD @DrArifK @fra_giannini1 @ProfDDKardiolog
#TAVI #StructuralHeart











































