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Exploring advances in Cancer Therapeutics, Targets & Resistance from Acta Materia Medica
Discover cutting-edge research: amm-journal.org/
#CancerResearch #CancerTherapeutics #DrugResistance #Oncology
This review examines how androgen receptor alterations contribute to CRPC and discusses PROTACs as tools for degrading proteins that sustain disease progression and therapeutic resistance. #CancerBiology #ProstateCancer @harvardmed
#AMM #OpenAccess: doi.org/10.15212/AMM-2024-00…
Acta Materia Medica retweeted
This review examines how androgen receptor alterations contribute to CRPC and discusses PROTACs as tools for degrading proteins that sustain disease progression and therapeutic resistance. #CancerBiology #ProstateCancer @harvardmed
#AMM #OpenAccess: doi.org/10.15212/AMM-2024-00…
A randomized trial found that Cs4 improved symptom severity, fatigue, insomnia, respiratory symptoms, and quality of life over 12 weeks in patients with long COVID. #ClinicalTrials #CordycepsSinensis @HKUniversity
#AMM #OpenAccess: doi.org/10.15212/AMM-2024-00…
Check the full article here👇
scienceopen.com/hosted-docum…
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Acta Materia Medica retweeted
A randomized trial found that Cs4 improved symptom severity, fatigue, insomnia, respiratory symptoms, and quality of life over 12 weeks in patients with long COVID. #ClinicalTrials #CordycepsSinensis @HKUniversity
#AMM #OpenAccess: doi.org/10.15212/AMM-2024-00…
Acta Materia Medica retweeted
💊 Not every disease-associated molecular change is a promising drug target.
In @DrugTargetRev , our Dr Shi-qi An explores how multiomics, single-cell and spatial technologies can strengthen drug target discovery.
🔗 drugtargetreview.com/home/ho…
Acta Materia Medica retweeted
Be Part of the Future of Pharmacology
Join PHARMAUE 2026 – 18th International Conference & Exhibition on Pharmacology, Drug Discovery & Pharmacotherapy.
Date: 8–9 December 2026
Venue: Kuala Lumpur, Malaysia & Virtual
Register Now: pharmacy.ucgconferences.com/…
This review highlights microneedles as a user-friendly strategy for enhancing transdermal insulin transport while overcoming gastrointestinal and skin barriers. #Pharmaceutics #DrugDelivery
#AMM #OpenAccess: doi.org/10.15212/AMM-2025-00…
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Acta Materia Medica retweeted
Join us at these upcoming conferences:
- Drug Discovery Chemistry Europe, November 10-12, Barcelona, Spain
drugdiscoverychemistry.com/e…
- The 43rd Medicinal Chemistry Symposium, November 11-13, Kyoto, Japan
k-gakkai.jp/mcs2026/en/en_in…
We will be happy to meet you, discuss the latest developments in Drug Discovery, and explore new opportunities for collaboration.
Acta Materia Medica retweeted
🇳🇱 Leiden University — PhD in AI-Driven Drug Discovery
🔥 URGENT | MSCA-Funded | Deadline: November 12, 2026
🏫 University: Leiden University
🔬 Laboratory: Leiden Academic Centre for Drug Research (LACDR) — Computational Drug Discovery Group
📍 Location: Leiden, Netherlands
🆕 Published: October 15, 2026
📖 Research Project:
ANA-KIN DC10 — Deep Learning for Kinase Drug Discovery
This PhD focuses on developing artificial intelligence models to discover new cancer therapeutics targeting protein kinases.
Unlike conventional kinase inhibitors, which primarily target ATP-binding sites, the project investigates alternative regulatory interfaces to improve drug selectivity and overcome resistance.
Research Activities:
•Develop deep-learning models for kinase inhibitor discovery.
•Integrate chemical, structural, and biophysical datasets.
•Predict molecular binding and drug-resistance mechanisms.
•Design computational approaches for peptide-based therapeutics.
•Apply AI models to experimental drug-discovery workflows.
•Develop open-source computational tools.
The position includes research secondments at two Belgian partner organizations.
💰 Funding Details:
✅ Fully funded through the Horizon Europe MSCA Doctoral Network ANA-KIN.
✅ Four-year salaried PhD position.
✅ Gross monthly salary: €3,204–€4,051.
✅ Additional 8% holiday allowance.
✅ Additional 8.3% year-end allowance.
✅ University pension and employment benefits.
✅ International research secondments and specialist training.
Contract Structure: Initial one-year appointment, extendable for the remaining three years after a positive evaluation.
🔍 Application Requirements:
•Master’s degree in Computer Science, AI, Computational Chemistry, Bioinformatics, or a related field.
•Experience with machine learning and deep learning, preferably PyTorch.
•Knowledge of cheminformatics or computational chemistry.
•Excellent Python programming skills.
•Strong academic English.
•Interest in pharmaceutical research.
MSCA Eligibility:
•Applicants must not already hold a doctoral degree.
•Applicants must not have lived, worked, or studied in the Netherlands for more than 12 months during the preceding 36 months, subject to MSCA exceptions.
Required Documents:
•Motivation letter confirming MSCA eligibility.
•Academic CV.
•Academic grade list.
•Contact details of two referees.
🕒 Application Deadline: November 12, 2026.
⏳ Time Remaining: 4 Days!
⭐ Why Apply?
This is an excellent opportunity to combine artificial intelligence with pharmaceutical research.
The project offers a competitive Dutch salary, international research experience, and collaboration with academic and industrial partners.
🔗 Official University Application:
careers.universiteitleiden.n…
#phd #PhD #phdopportunity #phdposition
Acta Materia Medica retweeted
POSTDOCTORAL FELLOWSHIPS IN MEDICINAL CHEMISTRY AT UNIVERSITY OF CAPE TOWN
👇👇👇👇👇👇👇👇
@PostdocPhd @PostdocO
The multidimensional biology of SKP2: mechanisms, pathologies, and emerging therapeutic frontiers. Click the link below to read this #open_access article. scienceopen.com/hosted-docum…
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DT-13 ameliorates LPS-induced acute lung injury via targeting NMMHC IIA to modulate the FOXO1/KLF2/SPHK1 pathway. Click the link below to read this #open_access article. scienceopen.com/hosted-docum…
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From osteoarthritis to rheumatoid arthritis: re-exploring the molecular pathways and therapeutic potential of diacerein. Click the link below to read this #open_access article. scienceopen.com/hosted-docum…
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Vicatia thibetica extract and chlorogenic acid improved skin structure, reduced oxidative stress, and enhanced epidermal barrier integrity in preclinical aging models. #Dermatology #SkinHealth #Aging
#AMM #OpenAccess: doi.org/10.15212/AMM-2026-04…
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Artificial intelligence in drug discovery — what it is, where we stand and the path forward
nature.com/articles/s41573-0…
rdcu.be/AbCjmkuPETra
This Perspective in the November issue provides recommendations to increase the translational relevance of AI uses in drug discovery
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👉
Funded PhD in the lab (open to international students)! Deadline Nov 27th. Work on enterovirus antivirals in a project covering medicinal chemistry, virology, proteomics, blood-brain models and clinical samples! findaphd.com/phds/project/mr…
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This study found that gut microbiota contributes to the pharmacokinetic interaction between berberine & astragaloside IV, with distinct interaction patterns observed in normal vs. T2DM rats. #Pharmacology #Diabetes #GutMicrobiota
#AMM #OpenAccess: doi.org/10.15212/AMM-2024-00…
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