Ankit Mahadevia retweeted
Let me be blunt. Those who are afraid of AI feel deep down that they are impostors & have no edge. If you have a 1) clear mind, 2) a deep, not just cosmetic, undertanding of your specialty, 3) and/or are original enough to reinvent yourself when needed, AI will be your friend.
Ankit Mahadevia retweeted
siRNAs and delivery systems are the future of medicine
Craig Mello kicking off the nephrology meeting ! @ASNKidney RNA medicines and oligo therapies will be the next generation cures for the kidney patients
many overlook compound interest of small wins towards big goals
The biggest daily motivator at work is not cash.
It is not praise.
It is visible progress on work that matters.
Most workplaces are feedback deserts.
You finish the day unsure whether you moved anything.
So do not wait for the world to notice.
At the end of the day, write down three things you advanced.
Small is fine.
Momentum is the point.
You cannot install motivation.
You can make progress visible enough that it returns tomorrow.
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Ankit Mahadevia retweeted
The biggest daily motivator at work is not cash.
It is not praise.
It is visible progress on work that matters.
Most workplaces are feedback deserts.
You finish the day unsure whether you moved anything.
So do not wait for the world to notice.
At the end of the day, write down three things you advanced.
Small is fine.
Momentum is the point.
You cannot install motivation.
You can make progress visible enough that it returns tomorrow.
Ankit Mahadevia retweeted
i have ALWAYS felt comfortable either
-talking to (or at) a large group/crowd
-at <6 person dinner table
-1:1 deeper personal mtg/coffee
i have NEVER felt comfortable
-large groups + small talk (cocktail parties, weddings)
thankfully i have wife + Lux partners who do!
Psychology says some people avoid socializing not because they hate people, but because they can read them too well. They walk into a room and immediately sense the fake laughs, the hidden agendas, the performances. Their nervous system doesn’t misread the signal, it just refuses to ignore it. Small talk feels like a tax they didn’t agree to pay. Forced smiles cost them energy that takes hours to recover.
They’re not broken. They’re calibrated differently. They don’t avoid people. They avoid emotional labor that leads nowhere. When they do connect, it’s deep, intentional, real. No masks. No games. Fewer friends doesn’t mean loneliness. It means higher standards.
That’s not antisocial behavior. That’s emotional intelligence.
Ankit Mahadevia retweeted
Underrated life advice: Just be easy to work with. Show up on time. Do what you said you'd do. Bring solutions, not problems. Never create drama. Be responsive. Be emotionally consistent. Be kind. People will always want to support someone who just makes their life easier.
If you're an introvert navigating a workplace that rewards extroversion, preparation and self-awareness go a long way. What's helped me is to know your audience, think ahead & lean into what genuinely makes you confident to speak up.
My thoughts on this - youtube.com/shorts/f53fCsg7E…
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A WSJ study caught my eye recently, extroverts may look like leaders the moment they walk into a room, but introverts tend to build followership that actually sticks.
There's a real difference between looking the part and playing it.youtube.com/shorts/vmML1Wbny…
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Great article - lot resonates after a very large 3 day gathering at our place medium.com/@johnpearce650/an…
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Biggest foot fault in state politics. Not sure letting the Bears escape to Indiana will be a great campaign slogan
The Illinois House ended its legislative session early this morning without final passage of a bill to support a #Bears stadium in Illinois.
Statement from the team:
“We will finalize our evaluation of both Arlington Heights and Hammond, and remain on the late spring/early summer timeline that we have previously communicated. We will provide an update when we have a decision to share."
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Longevity and effort is a huge explainer of outlier performance
In the 1920s, a Stanford psychologist tracked genius children for 50 years.
Malcolm Gladwell breaks down what he discovered:
Rich families → successful. Poor families → failures.
Not average. Failures. Genius-level IQs that produced nothing.
He spent 60 minutes at Microsoft explaining why we're wrong about success:
The psychologist was named Terman. He gave IQ tests to 250,000 California schoolchildren.
He identified the top 0.1%. Kids with IQs of 140 and above.
His hypothesis: these children would become the leaders of academia, industry, and politics.
He tracked them. And tracked them. For decades.
The results split into three groups.
The top 15% achieved real prominence. The middle group had average, moderately successful professional lives.
And the bottom group? By any measure, failures.
The difference wasn't personality. Wasn't habits. Wasn't work ethic.
It was simple: the successful geniuses came from wealthy households. The failures came from poor families.
Poverty is such a powerful constraint that it can reduce a one-in-a-billion brain to a lifetime of worse than mediocrity.
There's a concept called "capitalization rate."
It asks a simple question: what percentage of people who are capable of doing something actually end up doing that thing?
In inner city Memphis, only 1 in 6 kids with athletic scholarships actually go to college.
If our capitalization rate for sports in the inner city is 16%, imagine how low it must be for everything else.
Here's something stranger.
Gladwell read the birth dates of the 2007 Czech Junior Hockey Team:
January 3rd. January 3rd. January 12th. February 8th. February 10th. February 17th. February 20th. February 24th. March 5th. March 10th. March 26th...
11 of the 20 players were born in January, February, or March.
This isn't unique to the Czechs. Every elite hockey team in the world shows the same pattern. Every elite soccer team too.
Why?
The eligibility cutoff for youth leagues is January 1st.
When you're 10 years old, a kid born in January has 10 months of maturity on a kid born in October. That's 3 or 4 inches of height. The difference between clumsy and coordinated.
So we look at a group of 10 year olds, pick the "best" ones, give them special coaching, extra practice, more games.
We think we're identifying talent. We're just identifying the oldest.
Then we give the oldest more opportunities, and 10 years later they really are the best.
Self-fulfilling prophecy.
The capitalization rate for hockey talent born in the second half of the year? Close to zero.
We're leaving half of all potential hockey players on the table because of an arbitrary date on a calendar.
Kids born in the youngest cohort of their school class are 11% less likely to go to college.
11% of human potential squandered because we organize elementary school without reference to biological maturity.
Now here's the part about math.
Asian kids dramatically outperform Western kids in mathematics. The gap is enormous and consistent across decades of testing.
Some people say it's genetic. It's not.
It's attitudinal.
When Asian kids face a math problem, they believe effort will solve it.
When Western kids face a math problem, they believe the answer depends on innate ability they either have or don't.
Here's the proof.
The international math tests include a 120-question survey. It asks about study habits, parental support, attitudes.
It's so long most kids don't finish it.
A researcher named Erling Boe decided to rank countries by what percentage of survey questions their kids completed.
Then he compared it to the ranking of countries by math performance.
The correlation was 0.98.
In the history of social science, there has never been a correlation that high.
If you want to know how good a country is at math, you don't need to ask any math questions. Just make kids sit down and focus on a task for an extended period of time.
If they can do it, they're good at math.
Why do Asian cultures have this attitude?
Gladwell's theory: rice farming.
His European ancestors in medieval England worked about 1,000 hours a year. Dawn to noon, five days a week. Winters off. Lots of holidays.
A peasant in South China or Japan in the same period worked 3,000 hours a year.
Rice farming isn't just harder than wheat farming. It's a completely different relationship with work.
There's a Chinese proverb: "A man who works dawn to dusk 360 days a year will not go hungry."
His English ancestors would have said: "A man who works 175 days a year, dawn to 11, may or may not be hungry."
If your culture does that for a thousand years, it becomes part of your makeup.
When your kids sit down to face a calculus problem, that legacy of persistence translates perfectly.
Now consider distance running.
In Kenya, there are roughly a million schoolboys between 10 and 17 running 10 to 12 miles a day.
In the United States, that number is probably 5,000.
Our capitalization rate for distance running is less than 1%.
Kenya's is probably 95%.
The difference isn't genetic. The difference is what the culture values and where it spends its attention.
Here's the most fascinating finding.
30% of American entrepreneurs have been diagnosed with a profound learning disability.
Richard Branson is dyslexic. Charles Schwab is dyslexic. John Chambers can barely read his own email.
This isn't coincidence. Their entrepreneurialism is a direct function of their disability.
How do you succeed if you can't read or write from early childhood?
You learn to delegate. You become a great oral communicator. You become a problem solver because your entire life is one big problem. You learn to lead.
80% of dyslexic entrepreneurs were captain of a high school sports team. Versus 30% of non-dyslexic entrepreneurs.
By the time they enter the real world, they've spent their whole life practicing the four skills at the core of entrepreneurial success: delegation, oral communication, problem solving, and leadership.
Ask them what role dyslexia played in their success and they don't say it was an obstacle.
They say it's the reason they succeeded.
A disadvantage that became an advantage.
Here's what Gladwell wants you to understand:
When we see differences in success, our default explanation is differences in ability.
We forget how much poverty, stupidity, and attitude constrain what people can become.
We refuse to admit that our own arbitrary rules are leaving talent on the table.
We cling to naive beliefs that our meritocracies are fair.
The capitalization argument is liberating.
It says you don't look at a struggling group and conclude they're incapable. It says problems that look genetic or innate are often just failures of exploitation.
It says we can make a profound difference in how well people turn out.
If we choose to pay attention.
This 60 minute Microsoft talk will teach you more about success than every self-help book you've ever read combined.
Bookmark this & give it an hour today, no matter what.
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correlation vs causation?
Your morning coffee on an empty stomach is a cortisol bomb.
Cortisol follows a natural rhythm. It peaks when you wake up, then gradually drops through the day. Breakfast is the signal that tells your body to start pulling cortisol back down. Skip that signal and cortisol stays elevated for hours past its normal window.
Now add coffee. Caffeine directly stimulates your adrenal glands to produce more cortisol. So the actual sequence for millions of people every morning: wake up with peak cortisol, skip food, pour a stimulant into an already-stressed system, then wonder why they feel wired and anxious by 10 AM.
The mechanism connecting this to depression runs through serotonin. Your brain synthesizes serotonin from tryptophan, but tryptophan needs insulin to cross the blood-brain barrier. Insulin comes from eating. No breakfast means no insulin spike, which means less tryptophan reaching the brain, which means less serotonin production during the exact hours your brain is trying to stabilize mood for the day.
This study found the link is strongest in adolescents (51% higher odds of anxiety vs no significant link in adults). That tracks perfectly. Teenagers skip breakfast at the highest rate, sleep the least, and drink the most caffeine relative to body weight. Three compounding cortisol drivers stacked on a brain that's still developing its stress regulation systems.
399,550 people across 14 studies. The finding isn't that breakfast is magical. The finding is that your body uses that first meal as a hormonal reset button, and skipping it leaves your stress system running in the background all morning like an app you forgot to close.
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reason for optimism
While social media is polarising, evidence suggests AI may nudge people towards the centre.
This holds true of all studied models. Grok is more right-leaning than other models, but also has depolarising effects.
By @jburnmurdoch.
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すごい
If you’re seeing a bunch of Japanese posts, here are some fun facts:
Japan has more daily active users and more time spent on X than any other country in the world.
Over two thirds of the country is monthly active on X.
X in Japan has one of the highest penetration rates of any social network in history.
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