Barron lab @NTU_LKCMedicine @NTUsg Neuroscience lab studying #mitochondria #metabolism #microglia #aging and #Alzheimers
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Joined May 2020
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📢New paper out in #PNAS on mitochondrial control of microglial phagocytosis.
🧵A brief thread
pnas.org/doi/10.1073/pnas.22…
@PNASnews @NTU_LKCMedicine @NTUsg @alzforum
#mitochondria #microglia #Alzheimers #Immunometabolism
The Aging Brain Lab retweeted
Breaking boundaries in neuroscience! 🧠 Asst Prof Anna Barron (@AgingBrainLab), our new EMBO Global Investigator, explores mitochondria's role in brain health. Despite pandemic challenges, her commitment to knowledge remains unwavering.
Learn more: embo.org/people/putting-mito…
The Aging Brain Lab retweeted
Putting mitochondria on the map: learn about new EMBO Global Investigator Anna Barron and her research on cellular metabolism as a regulator of microglial fate and function
embo.org/people/putting-mito…
What a great end to 2023! Very excited to join the EMBO Global Investigator network and looking forward to the new opportunities it brings!
Ten life scientists are welcomed to the EMBO Global Investigator Network, which provides access to the EMBO networking and training activities
embo.org/press-releases/embo…
The Aging Brain Lab retweeted
Excited to share our Review Article published in Journal of Neuroinflammation where we discuss key mechanisms contributing to lysosomal acidification dysfunction in microglia. bit.ly/3DFzaXn Great collaboration with @JialiuZeng @jiahui_w20 @AMBarroness @AgingBrainLab!
Read more about our latest work here doi.org/10.1073/pnas.2209177…
💊 #NTUsg scientists may have found a way to spur brain immune cells into clearing toxic waste linked to #Alzheimers disease. This breakthrough could provide new possibilities for developing new drugs targeted at Alzheimer's disease. @NTU_LKCMedicine bit.ly/NTUsg-metabolicswitch
The Aging Brain Lab retweeted
Study shows new way to spur brain #immunecells to clear toxic waste linked to #Alzheimer'sdisease @PNASNews doi.org/grtbjj medicalxpress.com/news/2023-…
💡Congratulations to lead authors @LaurenHFairley1 @KeiOnnL @jiahui_w20 and collaborators including @AnselmVincent @SarahRLangley @gdagstn
🧵 (7/7)
To restore the immune cells’ clean-up function 🧹, we “switched off” glycolytic metabolism by removing hexokinase-2 bound to the mitochondria.
This spurred microglia to gobble up 🍽️ toxic proteins that can build up in the brain 🧠 leading to Alzheimer’s.
🧵 (6/7)
We developed an optogenetic strategy to remove hexokinase-2 from the mitochondria in living cells to test this. Using this, we could spur microglia into clean-up mode with a flick of the light switch !💡
🧵 (5/7)
ALT Mitochondrial hexokinase-2 displacement inhibits glycolysis and improves phagocytosis in cultured TSPO knockout microglia. Fairley et al. (2023) PNAS. 120(8):e2209177120. doi: 10.1073/pnas.2209177120.
These damaged microglia relied on glycolysis 🍬 for energy⚡.
The switch to glycolysis was controlled by binding of the glucose metabolizing enzyme, hexokinase-2, to the energy-producing 🏭 part of the cell, mitochondria.
🧵 (4/7)
ALT Heatmap showing the sugar metabolizing enzyme, hexokinase-2, stuck all over the mitochondria of the brain immune cells, microglia. Image credit: Kei Onn Lai.
In microglia, we found that the inflammatory marker, the translocator protein #TSPO, is critical for efficient energy production ⚡ and phagocytosis🍽️
Microglia lacking TSPO resembled damaged microglia observed in aging 👵 and Alzheimer's.
🧵 (3/7)
The immune cells of the brain, #microglia, need a lot of energy 💪 to clean up toxic waste ☠️ that can lead to #alzheimers 🧠
How is this fueled? 🔥
🧵 (2/7)
ALT Microglia (green) cluster around and infiltrate into lesions formed by the build up of toxic beta amyloid (red). Image credit: Anselm Vincent.
Latest work from the lab. Mitochondrial control of microglial phagocytosis in Alzheimer’s disease doi.org/10.1101/2021.12.01.4… @LaurenHFairley1 @KnockOutinLab
Our latest paper is out! Congratulations @LaurenHFairley1 !
Thrilled to share our recently accepted paper on the therapeutic effects of #TSPO in a model of tauopathy. @BioMedCentral @AMBarroness @AgingBrainLab @NTU_LKCMedicine @WomenAtNTU @alzassociation
jneuroinflammation.biomedcen…
The Aging Brain Lab retweeted
Excited to share our new article "Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease" @FrontImmunol @AgingBrainLab @NTUsg @WomenAtNTU @AMBarroness Jia Hui Wong
doi.org/10.3389/fimmu.2021.6…
The Aging Brain Lab retweeted
Our new paper out showing that the mitochondrial translocator protein is critical for brain steroidogenesis link.springer.com/article/10…
The Aging Brain Lab retweeted
Visualizing damaged mitochondria in Alzheimer’s mice authors.elsevier.com/c/1bKkH…
The Aging Brain Lab retweeted
Genetically targeted reporter imaging of deep neuronal network in the mammalian brain biorxiv.org/content/10.1101/…
