Doctoring + Researching @umichmedicine + @VAAnnArbor | Came for #MedTwitter but stay for #Epitwitter hot takes | Opinions My Own + Not Medical Advice

Joined April 2011
🚨New paper in @AnnalsofIM about everybody's favorite medication to hate🚨 Gabapentin is far from the perfect pain med, but the risk/benefit profile may be more complex than papers comparing users to non-users could have you believe Tweetorial en route! pubmed.ncbi.nlm.nih.gov/3976…
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Alexander Chaitoff retweeted
In a study @npjDigitalMed led by Bowen Gu and @JieHealthAI, we find that LLMs struggle to convey uncertainty and can be overly confident in their answer even when it is wrong. Imp area for research and improvement for detection of hallucinations.. nature.com/articles/s41746-0…
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This is the type of education everybody, but especially pre-meds + medical students, should be getting. Journal clubs are great and can teach some about biased study designs and reporting, but there are so many more lessons for most clinicians here. #Medtwitter #MedEd
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Alexander Chaitoff retweeted
Quantifying Pill Disutility Associated with Starting Versus Continuing Cardioprotective Medication: A Randomized Experiment @alexchaitoff @jlauffen #AHAJournals ahajrnls.org/3ZLNHwi
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Loved what this paper set out to do, but unfortunately my reading is there still isn't good evidence to deprescribe antihypertensive medications in older adults. Come learn why 👇 #Medtwitter #Cardiotwitter
🤔 #Digest 59: Whether to deprescribe BP Meds–A Confounding Question! Plus COVID/Flu vaccine co-administration safety, GLP-1RAs in the perioperative period, tirzepatide to prevent prediabetes, and the cardiovascular benefits of activity and time in BP range. #meded
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Ok most people feel 2nd author is distinct from other middle authors. Follow-up for #Medtwitter / #Epitwitter health services/clinical researchers: What is reasonable to expect from non-2nd middle authors (assume original articles being submitted to clinical journals)?
59%<5 hours of work
35%5-10 hours of work
0%>10 hours of work
6%Something else (comment)
17 votes • Final results
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Hey #MedTwitter #Epitwitter and whoever else does health services/clinical research, curious your thoughts about author contributions. Question 1: Assuming >3 authors on a paper, does second author carry any extra weight over being another middle author?
72%Yes
24%No
4%Depends (comment below)
25 votes • Final results
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Reminder that binary thinking about medications is not patient-centered. Less strong opinions about medicines being "good" or "bad." More opinions on the right medicine for the right patient at the right time. #medtwitter
#MentalHealthMatters: To augment or to replace 💊 for treatment resistant #depression? Read the paper in #JGIM: buff.ly/3Ysaflc Visual Abstract: @ShriGadrey
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Should medical journal editors provide any feedback on papers they desk-reject? #medtwitter what do you think? Please let me know why as well.
59%Yes
30%No
11%See options
46 votes • Final results
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For me, it's a yes. My practice is to point to very specific deficiencies that would not be addressable with the given data. If it's simply my perception of the importance, I'll try to cite something to support that. I find it adds an extra 15-20ish minutes per paper.
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We need an index that describes how often your paper is cited vs how often it is read. Said index for "Crossing the Quality Chasm" would be enormous. If you had to prove you read a paper before citing it, 92% of the background sections in the medical literature would be gone.
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Is there a service that offers patients a doctor/nurse to accompany them during outpatient visits? Like pay a small fee get an expert to help+make sure you're heard? The care my family gets for even simple concerns when I'm there vs when I'm not is staggeringly different.
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Alexander Chaitoff retweeted
NEW!!! 🎙️#459 DIGEST: Finerenone for Heart Failure, PCV21 and the latest Pneumonia Vaccine Recs, 24-hour vs 15-hour Oxygen Therapy, and PREVENT vs PCE for Cardiovascular Risk Estimation thecurbsiders.com/curbsiders…
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Cool idea in general, but still waiting for a trial proving that stopping meds folks are tolerating improves outcomes. We should stop meds that don't offer benefit regardless, but the speed/lengths we go to should depend on magnitude of risk reduction offered by deprescribing.
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I love working with friends. Some of that is selfishness. Some of it is that friends have given me some of the best feedback on ideas. I recommend the lack of hierarchy, honesty, kind skepticism, unbridled enthusiasm, and more that working with friends brings. #medtwitter
A Nature Biotechnology article suggests that doing good science is mostly having a friend to constantly talk about the project to. It’s an established tradition going back to at least Kahneman and Tversky in psychology and economics.
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New review w/ @AlexanderZheut1 - Epidemiology of Hypertension in Older Adults Are you looking for historical context? Disease and treatment prevalence estimates? Psychological and cost implications? Well then have we got an article for you #medtwitter👇 pubmed.ncbi.nlm.nih.gov/3934…
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Why risk-based prescribing for some things and not others. Why are surrogates endpoints ok for some things that reduce cardiovascular risk but not others? New drugs means lots of new areas to think about.
This was an interesting one to write! Thought experiment: why are we treating some medications that reduce weight and cardiovascular risk differently from the way we treat other meds that reduce other CVD risk factors? @AlexChaitoff
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Alexander Chaitoff retweeted
With today's Senate hearing on #weightloss medication costs, here's timely work by @AlexChaitoff & colleagues on the potential portion of #Medicare enrollees who could qualify for semaglutide coverage, depending on what #cardiovascular cutoff is: ihpi.umich.edu/news/heart-qu…
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