Biochemist in large pharma. Knob domains and chemical biology.
San Diego, CA
Joined July 2015
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In our new @PLOSBiology paper, we show that a mini domain found in the CDRH3 of a subset bovine antibodies can function autonomously of the antibody scaffold, creating a small (~4 kDa), cysteine-rich antibody fragment, one third the size of a VHH journals.plos.org/plosbiolog… – at Bagshot, South East
Alex Macpherson retweeted
As @JeanvdElsen exquisitely summed it up in his historical perspective of the field, "there is complement structural biology before...and after Piet Gros"!
What an impactful legacy!
Alex Macpherson retweeted
PhD position available: unravelling the molecular link between coagulation and immunity. Supervisory team @HeurichMeike (Cardiff), Halina Mikolajek (Diamond Light Source) and myself (Bath)
gw4biomed.ac.uk/unravelling-…
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Alex Macpherson retweeted
DNA is good for information storage.
Peptides are better.
This @ScienceMagazine article makes a compelling case for peptides encoded small-molecule libraries.
A powerful new approach for drug discovery.
Alex Macpherson retweeted
New tool helps scientist understand how MRSA superbug avoids immune detection bath.ac.uk/announcements/new… @Toska_Wonfor, Maisem Laabei, Shuxian Li, @DunphyRhys, @Alex_MacPh @LifeScienceBath @UniofBath
Alex Macpherson retweeted
He's only gone and done it!! Congratulations Dr @DunphyRhys!! Many thanks to the excellent team of examiners @JodyMMason and Nic Harmer!! @GW4BioMedDTP @BiosciencesBath
Alex Macpherson retweeted
SWBio DTP PhD opportunity @UniofBath @BiosciencesBath in collaboration with @cardiffuni and @Alex_MacPh findaphd.com/phds/project/sw…
Delighted that our paper has been published in MAbs. We show that the proximity of the termini of bovine knob domains enables transplantation into protein loops, to engineer binding specificity into proteins and antibodies. @TheAbSociety @JeanvdElsen tandfonline.com/doi/full/10.…
Alex Macpherson retweeted
The latest paper from our lab in @FrontImmunol unveils a novel staphylococcal #complement evasion mechanism which enables the pathogen to harness the ability of dimeric C3d to modulate B-cell activation via a unique structurally stabilising domain swap. frontiersin.org/articles/10.…
Alex Macpherson retweeted
I'm pleased to announce a PhD opportunity @UniofBath to study complement C5, a target for inflammatory diseases, using a unique antibody toolkit. This a collaboration with Prof Paul Morgan, Dr Wiola Zelek @cardiffuni and @Alex_MacPh @ucb_news cpb-eu-w2.wpmucdn.com/blogs.… DM for info
1. Hugely pleased this is out in @ChemicalBiology. We show that knob domains, antigen binding mini-domains found in a subset of bovine antibodies, are readily amenable to SPPS, creating truely synthetic antibody fragments. pubs.acs.org/doi/10.1021/acs… – at Bagshot, South East
2. This permits incorporation of non-natural amino acids or other chemical modifications which further improve the in vivo stability of these scaffolds. – at Bagshot, South East
3. Huge thanks to @JeanvdElsen and many other colleagues @ucb_news and @UniofBath who contributed. – at Bagshot, South East
Alex Macpherson retweeted
The world's tiniest antibodies can be chemically synthesised!! @Alex_MacPh et al @ChemicalBiology: pubs.acs.org/doi/10.1021/acs…
Alex Macpherson retweeted
Latest paper from the lab: providing new insights in the importance of complement in the fluid phase and how C3 fragment dimers modulate B cell activation. Great collaboration between Bath, Newcastle, Colorado and UCB. frontiersin.org/articles/10.…
Alex Macpherson retweeted
We are launching @FrontiersIn E3 Ubiquitin Ligases: From Structure to Physiology to Therapeutics, Volume II frontiersin.org/research-top…
@IkedaResearch @FleurMFerguson Dr Victor Bolanos-Garcia Dr Heike Laman @licchesilab
#ubiquitin #PROTAC #E3ubiquitinligase. Please RT, thanks.
Alex Macpherson retweeted
Hot off the preprint press:
The world's tiniest antibodies can be chemically synthesised!!
@Alex_MacPh's latest chapter in the continuing knob domain peptide saga:
biorxiv.org/content/10.1101/… #antibody #complement #peptide
"Re-mapping of Conformational Distributions Using Small Molecules" featuring an impressive analogy about a canal bridge. frontiersin.org/article/10.3… – at Bagshot, South East
An exciting opportunity for a permant position at UCB in Slough. The role involves working within the Immunology TA, to characterise the cellular pharmacology of a novel peptide modality.
Check out this job at UCB: linkedin.com/jobs/view/24734… – at Slough, South East
Alex Macpherson retweeted
A new research paper in the journal eLife on the inhibition of #complement C5 by peptides derived from cow #antibodies , and the potential use of these #peptides as anti-inflammatory #therapeutics. Congratulations to @JeanvdElsen and his co-authors!
complement.org.uk/publicatio…
Thanks to @JodyMMason and @gregers_rom for a really interesting viva. Whilst I'm sad that my PhD is finishing, I couldn't have asked for better supervisors in @JeanvdElsen and Alastair Lawson. Such a good experience. – at Bagshot, South East
He did it!!! Many congratulations on passing your PhD viva @Alex_MacPh!!! Many thanks to the excellent examiners @JodyMMason and @gregers_rom Andersen #complement @BiosciencesBath
