Director, Institute of Lung Health and Immunity (@LungHealthMUC) Researcher @HelmholtzMunich, Immunologist, COPD @Copd_Inet, Soccer fan, opinions are my own!

Munich
Joined June 2013
Why does COPD affect women and men differently? Our latest work in @JCI_insight points to estrogen-driven sphingolipid metabolism as a contributor to airway hyperreactivity and remodeling in COPD, highlighting a potential sex-specific disease mechanism. #CureCOPD #LungResearch 🔗 insight.jci.org/articles/vie…
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The most comprehensive guidance to date on preclinical COPD models is finally out in the ERJ @ERSpublications 🔗 publications.ersnet.org/cont… #COPD #RespiratoryResearch After a tremendous collaborative effort with leading COPD investigators worldwide, this document provides practical recommendations on choosing the best COPD model for each scientific question. We hope it becomes the go-to reference when selecting preclinical COPD models.
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Does brain aging always mean vessel loss? 🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵biorxiv.org/content/10.64898… Led by @MihailMuc
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#WorldCOPDDay “Short of Breath, Think COPD” Helmholtz Munich Drives Research for New Diagnostics, Therapies and Prevention Strategies🫁 👉t1p.de/2sxmc #COPD, the Chronic Obstructive Pulmonary Disease, is a progressive and currently incurable lung disease in which the airways become inflamed and permanently narrowed (obstruction). 💡Worldwide, COPD ranks as the third leading cause of death, with over three million people affected in Germany alone. The challenge: lung damage can occur long before a formal diagnosis is made. Early warning signs like coughing or shortness of breath are often overlooked or underestimated. The World COPD Day 2025 aims to raise awareness of COPD and to highlight the importance of early diagnosis, as the disease is often detected too late. 🌟At #HelmholtzMunich, researchers are driving the development of new diagnostics, therapies, and prevention strategies for COPD. The goal is to understand the immunological foundations of the disease, the impact of nutrition and environmental factors, and how these influences interact with the immune system during the onset and progression of COPD. 👉Check out the Research Highlight “New Hope for Lung Diseases”: t1p.de/lormr @DZG_Forschen @GOLD_COPD @AlionderCPC @LungHealthMUC @StiftungAtemweg #GOLDCOPD2025 #COPDAwareness #LungHealth #ThinkCOPD
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We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi biorxiv.org/content/10.1101/… 1/n
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BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2025 #NobelPeacePrize to Maria Corina Machado for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transition from dictatorship to democracy. #NobelPrize
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Learn what’s new in the 2026 GOLD Report! Highlights include a revised chapter on COPD & multimorbidity, updated guidance on exacerbation management, case-finding, treatment algorithms, and vaccinations. Hear directly from the experts on these key updates! November 12–13 | Philadelphia Marriott Downtown. Register today: bit.ly/3FDHJ99 #GOLDCOPD2025
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Treatable traits! New! We compare inflammation, microbiome, rheology and mucins in asthma, COPD, bronchiectasis, CF and controls. Huge overlap in biology but clear neutrophilic and T2 endotypes in all diseases! Endotypes>disease labels @accpchest journal.chestnet.org/article…
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The Resilience of the Human Lungs: Evolution, Smoke, and Disease Lung resilience evolved with fire exposure; studying protection in smokers may unlock new COPD therapies amid modern threats @atscommunity 🔓 Open Access 🔗 tinyurl.com/y4b4sh9f
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The Unagi paper is FINALLY out! We present the first application. of a novel AI tool to human pulmonary fibrosis snRNAseq data to identify cellular trajectories & reversak perturbations with proteomics & PCLS validations!! See 🧵 👇🏼 and paper here nature.com/articles/s41551-0…
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The new European Respiratory Journal impact factor is 21. Ranked #2 across all resp journals Thank you to the incredible @donsin4 , all authors, our outstanding editors and journal staff ♥️ @ERSpublications @EuroRespSoc IF for selected respiratory journals below
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Wrapping up #ATS2025 with @LungAssociation’s CMO Alberto Rizzo and CEO @HaroldWimmer. Grateful to the @LungAssociation for their support of the @atscommunity and @copd_inet. Let’s keep driving science forward—together. #COPD #cureCOPD Link 🔗 hcplive.com/view/lungcast-at…
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📜The European Respiratory Journal is calling for new submissions of original research articles, review papers, research letters & viewpoints for a series on COPD in response to the global challenge the disease poses Learn more & submit online by 30 June: bit.ly/44t7SSE
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A beautiful editorial by the great @FrancyPolverino and @meilan_han on why we need to study the airways of #COPD rather than the blood (which is useless in identifying biomarkers for COPD) bit.ly/3EvEwrX
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Finally! The Pulmonary Fibrosis Drug Connectome is on #IPFCellAtlas!! If you want to know if a drug is antifibrotic, which cells it targets, or what drugs target a gene , in what cells - go to ipfcellatlas.com/ click on the Connectome tab. Enjoy!! #DataSharing #CurePF4All
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“Humans have long coexisted with fire and smoke, and this exposure has significantly influenced our biology—especially our lungs. Cooking food, staying warm, and surviving in primitive shelters all meant constant interaction with smoke. This exposure likely played a role in shaping the lung’s defense systems, suggesting they may be among the most resilient organs in the body, though not indestructible”. We discuss the resilience of human lung in the new Turning the Air Blue @ATSBlueEditor Viewpoint atsjournals.org/doi/abs/10.1…
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Have a look at our current @JCI_insight issue. I hope everyone loves the artwork provided by our soon-to-be-scientists!!
Our current issue's special collection of Physician-Scientist Development articles includes an editorial by Editor in chief @Eickelberg_MD & is paired with a cover collage of children's drawings illustrating what a 'physician-scientist' means to them: insight.jci.org/articles/vie…
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