Allan Mah (@AllanKMah) profile picture

Allan Mah

@AllanKMah
 Vancouver, British Columbia
Joined May 2009
  • Tweets1.1K
  • Following350
  • Followers100
4Media
Photo by Allan Mah (@AllanKMah)Photo by Allan Mah (@AllanKMah)Photo by Allan Mah (@AllanKMah)
NEWS: Gandeeva and Zymeworks Use Cryo-EM to Accelerate Antibody Drug Discovery: gandeeva.com/gandeeva-and-zy…
Image from Gandeeva Therapeutics (@Gandeeva_Tx)
2
2
113
Cryo-EM focused biotech from longtime NIH veteran secures $40M backing from Bayer in Series A - endpts.com/cryo-em-focused-b…
Cryo-EM focused biotech from longtime NIH veteran secures $40M backing from Bayer in Series A

Cryo-EM focused biotech from longtime NIH veteran secures $40M backing from Bayer in Series A

“It’s always nice to get money in the bank.” That’s what Gandeeva Therapeutics’ founder and CEO Sriram Subramaniam said after revealing that his company landed $40 million in Series A ...

endpoints.news
Excited to announce our US$40 million Series A funding led by @Lux_Capital and @LeapsByBayer! Our AI-driven #cryoEM platform aims to accelerate the discovery, design and development of novel precision medicines and breakthrough cures to patients ow.ly/wQwh30s971I @UBC
Image from Gandeeva Therapeutics (@Gandeeva_Tx)
8
3
50
Thrilled to announce the launch of @Gandeeva_Tx! Our mission is to harness the power of computation and experimentation to enable breakthroughs in precision medicine.
Gandeeva Therapeutics (@Gandeeva_Tx) profile pictureGandeeva Therapeutics@Gandeeva_Tx31 Jan 2022
Excited to announce our US$40 million Series A funding led by @Lux_Capital and @LeapsByBayer! Our AI-driven #cryoEM platform aims to accelerate the discovery, design and development of novel precision medicines and breakthrough cures to patients ow.ly/wQwh30s971I @UBC
Image from Gandeeva Therapeutics (@Gandeeva_Tx)
7
6
75
Sriram Subramaniam and Gerard Kleywegt discuss how structure prediction and cryo-EM/cryo-ET will synergize to tackle challenging biological questions regarding conformational dynamics and in situ structure analysis. @cryoem_UBC @UBC @emblebi @PDBeudrope nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
21
4
68
It’s finally here!! Our Method of the Year 2021 is….Protein Structure Prediction!! nature.com/nmeth/volumes/19/…
Image from Nature Methods (@naturemethods)
12
375
71
1,673
Thank you @wired @tsimonite for featuring our work on the Omicron variant. AI predictions continue to become increasingly central and transformative for structural biology, however the gold standard will always be direct measurement, and that’s what #cryoEM delivers.
WIRED (@WIRED) profile pictureWIRED
@WIRED10 Jan 2022
New algorithms that decipher complex sequences of amino acids offered an early view of the coronavirus variant. “These tools allow you to make an educated guess really quickly—which is important in a situation like Covid.” wired.trib.al/Djjyyga
This AI Software Nearly Predicted Omicron’s Tricky Structure

This AI Software Nearly Predicted Omicron’s Tricky Structure

New algorithms that decipher complex sequences of amino acids offered an early view of the coronavirus variant. They could point the way to future drugs.

wired.com
5
2
30
Delighted to have contributed a commentary article for Nature Method’s Method of the Year 2021 issue! Machine learning based predictions and #cryoEM technology are the new yin and yang of structural biology. The mix is a game-changer for drug discovery: go.nature.com/3Ibdu5J
Nature Methods (@naturemethods) profile pictureNature Methods@naturemethods11 Jan 2022
It’s finally here!! Our Method of the Year 2021 is….Protein Structure Prediction!! nature.com/nmeth/volumes/19/…
Image from Nature Methods (@naturemethods)
1
20
4
93
Just posted @biorxivpreprint manuscript reporting neutralizing antibody evasion and #CryoEM atomic-level structure of #COVID19 #OmicronVariant spike protein-ACE2 interface (PDB 7T9L), suggesting rationale for increased transmissibility of #Omicron biorxiv.org/content/10.1101/…
Image from Sriram Subramaniam (@cryoem_UBC)
14
134
24
403
#CryoEM structure of #Omicron (B.1.1.529) variant spike protein in complex with human ACE2 reveals new salt bridges formed by mutated residues R498 and R493 in the RBD and residues D38 and E35, respectively, in ACE2.
Image from Sriram Subramaniam (@cryoem_UBC)
23
272
48
858
Excited to celebrate the launch of Gandeeva Therapeutics! #cryoEM #StructuralBiology The University of British Columbia lnkd.in/gq8XYJAs
4
2
28
BREAKING: 'A milestone in oncology’: $AMGN KRAS-blocking drug proves effective for lung cancer... statnews.com/2021/01/28/amge… Sotorasib data released early due to #WCLC20 embargo break.

‘A milestone in oncology': Amgen’s KRAS-blocking drug proves effective for lung cancer patients in...

An Amgen drug designed to block the cancer protein KRAS shrank tumors in 37% of patients with advanced lung cancer, according to new data.

statnews.com
10
69
11
178
With Rare Speed, Gene Editing Emerges as Biotech’s New Cutting Edge barrons.com/articles/with-ra… via @Barronsonline
With Rare Speed, Gene Editing Emerges as Biotech’s New Cutting Edge

With Rare Speed, Gene Editing Emerges as Biotech’s New Cutting Edge

Stocks of start-ups wielding tools like Crispr-Cas9 that allow companies to edit DNA and attack genetic diseases and cancer are suddenly hot. But the science is moving with incredible speed and the...

barrons.com
80,151 confirmed cases, 2,701 deaths, an updated (1/24) daily report from #china with <1% new cases. 2019–20 #coronavirus outbreak, en.wikipedia.org/w/index.php… (last visited Feb. 25, 2020) #CoVid19 #covid #SARSCoV2
Image from Nathan Letts, PhD 🇺🇦🇺🇦🇺🇦 (@Sciguy999)
Image from Nathan Letts, PhD 🇺🇦🇺🇦🇺🇦 (@Sciguy999)
1
mTOR suppresses PD-L1 expression in tumor cells, pointing to antagonistic roles for mTOR signaling in oncogenesis. #immunotherapy nature.com/articles/s41388-0…
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells...

Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells...

Oncogene - Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation

nature.com
1
Scientists Created Bacteria With a Synthetic Genome. Is This Artificial Life? nyti.ms/2WLwwrU
MIT AI model is 'significantly' better at predicting breast cancer engadget.com/2019/05/07/mit-… via @engadget
MIT AI model is 'significantly' better at predicting breast cancer - Engadget

MIT AI model is 'significantly' better at predicting breast cancer - Engadget

MIT researchers have invented a new AI-driven way of looking at mammograms that can help detect breast cancer in women up to five years in advance. A deep learning model created by a team of resear...

engadget.com
Pharma Companies Will Soon Be Required to List Drug Prices in TV Ads gizmodo.com/pharma-companies… via @gizmodo
Pharma Companies Will Soon Be Required to List Drug Prices in TV Ads

Pharma Companies Will Soon Be Required to List Drug Prices in TV Ads

TV ads for prescription drugs are already annoying as hell, but those drug ads are about to get even more absurd. The U.S. government will soon require

gizmodo.com
Oceans are a bank of viral diversity - Hundreds of thousands of marine viruses discovered in world's oceans nature.com/articles/d41586-0…
1
Gene therapy works for bubble boy disease sciencemag.org/news/2019/04/…
Load more