Here is an important report from @alexanderjdile A report on how "seemingly safe" papaya leaf extract taken for low platelet count resulted in severe injury in the person. Papaya leaf extracts (raw, homemade) as well as Pharma company marketed are widely prescribed by both doctors and alternative medicine practitioners as a supposed treatment for low platelet count, especially during dengue season. This is a practice that is not evidence based. In fact, the largest metanalysis on this topic from SriLanka showed that papaya leaf had no significant effect on platelet count when used in dengue fever. Even we had reported cases with severe injury due to papaya leaf used in chronic liver disease. pmc.ncbi.nlm.nih.gov/article… People may argue that this is just one case report. And side effects are so rare, so what seems to be the problem? Rare side effects become extremely significant when there are no clinically relevant benefits in using a drug or supplement. Close to 60% snake bites are dry bites...meaning the snakes do not purposefully cause envenomation. That does not mean snakes are friendly.