Radiation oncologist, University of Florence
Joined November 2010
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Isacco Desideri retweeted
Thank you for the support ❤️ For playing, sharing, and being a part of the community.
#CONTROLResonant
Isacco Desideri retweeted
Excited to share our new paper with @Mitch_P and @Luke_Pike_MD @pike_lab!
Nearly 4,000 brain mets patients treated with linac-based SRS at MSK: contemporary survival outcomes, prognostic factors, and what happens next with salvage treatment. 🧵
doi.org/10.1093/noajnl/vdag2…
Isacco Desideri retweeted
Manhattan is on the brink of paranatural annihilation. The fundamental aspects of our reality are changing, and Dylan Faden must harness his new-found powers to contain the danger, take back the city, and fight for control.
d
Nothing stays contained forever. CONTROL Resonant is out now!
#CONTROLResonant
Isacco Desideri retweeted
Excited to share our new review on the developmental origins of brain cancer! We discuss how gliomas co-opt neural development programs and how the tumor–neuron interface may reveal new therapies. A joy to work with @BhaduriLab & @FilbinMariella! Link: shorturl.at/T12Mn
Isacco Desideri retweeted
Craniospinal Irridation Protons must be better than Photons?!?
According to MDACC study not so much
· No diff TTP, AEs, OS, CBCs
· VMAT assoc w/ lower odds hospitalization
#ASTRO26
sciencedirect.com/science/ar…
Isacco Desideri retweeted
We have waited more than a decade for this: ROAM is presented in Rome #EANO2026! See the results of ROAM/EORTC-1308, now also published in @TheLancet!
@EANOassociation
thelancet.com/journals/lance…
Isacco Desideri retweeted
INTRAGO-II is now published in @TheLancetOncol and the result is what decades of evidence predicted: dose escalation does NOT improve survival in glioblastoma.
Here's what the data show:
🔴 90 Gy 3D-CRT? No OS benefit (Chan, JCO 2002)
🔴 SRS boost (15-24 Gy)? No OS benefit (RTOG 93-05, Souhami, IJROBP 2004)
🔴 Brachytherapy to 110 Gy? No OS benefit (Welsh, IJROBP 2007)
🔴 MRS-guided 72 Gy + TMZ? No OS benefit (SPECTRO GLIO, Laprie, Neuro-Oncology 2024)
🔴 IORT 30 Gy boost? No OS benefit (INTRAGO-II, Giordano, Lancet Oncol 2026)
🟡 Protons 75 Gy? Statistically met a relaxed threshold (α=0.15) but clinically negligible ~2.5 wk gain (NRG-BN001, Mehta, ASTRO 2025)
GBM cells infiltrate centimeters beyond what we can see or target. No amount of local dose intensification overcomes that biology. As INTRAGO-II's own authors conclude: this "questions the value of further local dose intensification in resectable glioblastoma."
We owe our patients innovation, not repetition. It's time to stop repackaging the same failed hypothesis with a different modality and redirect resources toward approaches that address GBM's fundamental biology
#GBM #Glioblastoma #RadOnc #NeuroOnc #INTRAGO #CNSOncology
Isacco Desideri retweeted
Very stable genius.
WOW -- Trump crashes out and cuts his interview with Welker short as she presses him on his lack of evidence for claiming elections are rigged
"You're either crooked or you're stupid. Let's call it quits. Because I've had enough. Thank you darling," he tells her."
"I traveled all the way to Wisconsin for this interview," she pleads.
Isacco Desideri retweeted
Day FOUR of #ESTRO26 Coverage by OncoAlert 🚨
PERSIAN TRIAL (NCT03449719): a randomized phase II trial testing Apalutamide and SBRT for hormone-sensitive prostate cancer Presented by Giulio Francolini 🇮🇹
#RadOnc ☢️
The PERSIAN randomized phase II trial evaluated apalutamide ± SBRT in oligometastatic hormone-sensitive prostate cancer. Biochemical response rates were high in both arms, with no significant differences overall. A consistent numerical trend favoring SBRT was observed, particularly in patients with higher disease burden. Treatment was well tolerated, with limited interruptions. These findings suggest a potential role for SBRT alongside systemic therapy in selected patients.
@ESTRO_RT
@yasemin09896924
@LindaMrissa
@christian_roenn
@Valeriadionisi
@gerryhanna
@clchiang_hk
@mtugceyilmaz
@B_Tomasik
@gmpetrianni
@CiroFranzese1
@Atem84
@piet_ost
@brachyexpert
@BlanceS90
@The_PT_Explorer
@BarbaraJereczek
@Mat_Guc
@ZilliThomas
@AnnaKirby17
@PBlanchardMD
@achoud72
Pinging OA faculty
@MKnoll_MD
@_ShankarSiva
@Icro_Meattini
@seanmmcbride
@NiuSanford
@nataliagandur
@acampsmalea
@to_be_elizabeth
Isacco Desideri retweeted
Join us in sending birthday greetings to the guitarist as we build a RF@80 song playlist celebrating his 80th year. Find out more at
dgmlive.com/news/happy-birth…
Isacco Desideri retweeted
#ESTRO26 - INTRAGO phase III trial Dr Frank Giordano investigated that dose escalation in #glioblastoma #braincancer. Using single fraction intra-operative #radiotherapy dose escalation did not improve outcomes. Congrats to authors completing this challenging trial!
Agreed. GBM is unfortunately a much more complex disease to be effectively treated only by tweaking dose and volume. #ESTRO2026 – at Stockholm, Sweden
No improvement in oncological outcomes with intraoperative dose escalation in GBM patients. Time to shift from dose and volume to other approaches in this uncurable disease. #ESTRO2026 – at Stockholm, Sweden
Long term outcomes of conventional fractionated re-irradiation in recurrent pediatric ependymomas: prolongs survival but concerns regarding long-term complications. #ESTRO2026 – at Stockholm, Sweden
