@BaiLab_PSU

Pioneering transcription factors and long-distance chrromosomal interactions @penn_state @PSUScience @BMB_PSU @PhysicsAtPSU (student-run account)

 University Park, PA
bailab.org/
Joined August 2021
  • Tweets92
  • Following284
  • Followers331
22Media
The entire Bai lab attended @ASBMB Transcriptional Regulation. We were so excited to present posters and to hear Lucy give a talk!
1
1
31
2,291
Bai Lab PSU retweeted
ASBMB@ASBMB27 Sep 2024
Our meeting on transcriptional regulation is underway! Next up: a session on #chromatin, genome architecture and remodelers. asbmb.org/meetings-events/tr… #RNA #ASBMB
Five attendees of ASBMB's transcriptional regulation meeting smile while wearing conference badges and standing in front of a large window. Trees are outside.

ALT Five attendees of ASBMB's transcriptional regulation meeting smile while wearing conference badges and standing in front of a large window. Trees are outside.

Two attendees of the ASBMB's meeting on transcriptional regulation smile for a photo. One attendee is wearing a baseball cap and grey quarter zip pullover, the other attendee is wearing a black, long-sleeve polo shirt.

ALT Two attendees of the ASBMB's meeting on transcriptional regulation smile for a photo. One attendee is wearing a baseball cap and grey quarter zip pullover, the other attendee is wearing a black, long-sleeve polo shirt.

Three attendees of ASBMB's meeting on transcriptional regulation smile for a photo. There is a plant and wood column behind them.

ALT Three attendees of ASBMB's meeting on transcriptional regulation smile for a photo. There is a plant and wood column behind them.

Six attendees of ASBMB's conference on transcriptional regulation sit at a round table in a conference room. There are five other tables behind them at which attendees are seated eating lunch and conversing.

ALT Six attendees of ASBMB's conference on transcriptional regulation sit at a round table in a conference room. There are five other tables behind them at which attendees are seated eating lunch and conversing.

4
12
1,207
Exciting news! 🎉 @lab_poirier and @rcollepardo have curated an amazing @MGO_BPS program for the 2025 BPS Meeting! Featuring top speakers like @seresanu, @BaiLab_PSU, @McGintyLab, @AnnaPanchenko13, Shoji Takada, and Marcus Woodworth from @Melike_Lak. Don’t miss it! 🚀✨ #BPS2025
5
1
21
3,709
We are hiring! The Department of Biochemistry and Molecular Biology at Penn State ⁦@BMB_PSU⁩ invites applicants for multiple tenure-track Assistant Professor positions in the broad areas of genetics, cell and developmental biology! Check us out! psu.wd1.myworkdayjobs.com/en…
38
3
48
10,446
Out now in Molecular Cell! Along with Tan and Mahoney labs, we combine cellular, in vitro, and computational methods to understand how sequence features affect pioneer factor specificity (cofactors play a big role) doi.org/10.1016/j.molcel.202…
3
10
1
46
5,356
This work was led by bai lab students Cheng Xu (now a postdoc with @JefBoeke) and @hekleinschmidt (grad student @BMB_PSU).
2
370
Bai Lab PSU retweeted
Manuel Llinas@LlinasLab7 Jul 2024
Very proud of this highly collaborative paper with the @mahonylab @RemoRohs and Gordân labs in which we explore how ApiAP2 transcription factors with similar DNA binding specificities define their target genes, a ubiquitous challenge in all cells! academic.oup.com/nar/advance…?

DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the...

Abstract. Development of the malaria parasite, Plasmodium falciparum, is regulated by a limited number of sequence-specific transcription factors (TFs). Ho

academic.oup.com
3
15
57
4,363
Check out our new Pioneer Factor review! We present both sides of the debate about whether pioneer factors have unique properties among TFs tandfonline.com/doi/full/10.…

Pioneer factors: nature or nurture?

Chromatin is densely packed with nucleosomes, which limits the accessibility of many chromatin-associated proteins. Pioneer factors (PFs) are usually viewed as a special group of sequence-specific ...

tandfonline.com
4
18
954
Congratulations to the Bai lab's newest PhD Yi Li of @BMB_PSU! Yi's main thesis project was published today!
14
382
Check out our latest paper in @NatureComms where we develop a methylation-based sequencing assay to capture chromosomal interactions with a viewpoint nature.com/articles/s41467-0…

DNA methylation-based high-resolution mapping of long-distance chromosomal interactions in nucleo...

Nature Communications - Here, the authors present MTAC, a method to map chromosomal interactions in budding yeast. By applying MTAC to various viewpoints, they find that most of the long-distance...

nature.com
14
44
5,037
Bai lab PhD students James (@BMB_PSU) and Cheng (@huckinstitutes MCIBS) graduated yesterday! James has started as a biologist at @theNCI and Cheng is starting as a postdoc with @JefBoeke!
8
448
Check out our latest work in @eLife! This work, led by graduate student James (graduating Sunday) uses a range of techniques, including a new methylation-based method to dissect gene cluster in haploid yeast. doi.org/10.7554/eLife.96028

Transcription factor condensates, 3D clustering, and gene expression enhancement of the MET regulon

The condensates of activator Met4 are associated with 3D clustering of the MET regulon and its enhanced expression.

elifesciences.org
1
2
12
1,750
Congratulations to the Bai lab's newest PhD, Cheng Xu!
1
19
653
Cheng's primary work is available currently as a preprint. Be on the lookout for more great work as Cheng transitions to a post doc very soon! biorxiv.org/content/10.1101/…

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor...

Despite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of...

biorxiv.org
2
208
Bai Lab PSU retweeted
Manyu Du@manyu_du9 Jan 2024
Excited to share my postdoctoral work is now online @CellCellPress thanks to all the coauthors that contributed to this work!
Cell@CellCellPress9 Jan 2024
Now online! Direct observation of a condensate effect on super-enhancer controlled gene bursting dlvr.it/T177rp
7
16
1
63
13,113
Congrats to the Bai lab's newest PhD! James passed his defense on Friday and is off to the NIH as a biologist!
1
13
833
Preprint now available: we investigated the binding specificity of pioneer factor FoxA1 by developing a high throughput synthetic approach ChIP-ISO. biorxiv.org/content/10.1101/…

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor...

Despite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of...

biorxiv.org
1
5
1
20
7,641
Bai Lab PSU retweeted
Shaun Mahony@mahonylab8 Nov 2023
.@KellerCaponePhD's Genomics Research Incubator is an amazing and unique resource in the Center for Eukaryotic Gene Regulation at @huckinstitutes @penn_state. Want to perform regulatory genomics assays? Or are you developing a new sequencing assay? Cheryl is ready to assist.
Penn State Eberly College of Science@PSUScience7 Nov 2023
Established under the leadership of Cheryl Keller, research professor of biochemistry and molecular biology, the Genomics Research Incubator is available to aid and enhance research and training at #PennState. buff.ly/47fE9e8 @KellerCaponePhD @huckinstitutes
5
14
1,977
Bai Lab PSU retweeted
Pew Health@pewhealth24 Oct 2023
Katsuhiko Murakami, Ph.D., and Gene-Wei Li, Ph.D., are delving into the intricate genetics of cyanobacteria, a diverse group of microorganisms that play a crucial role in supporting healthy ecosystems—from ocean depths to desert landscapes.
Image of cells in blue with 2023 Pew Innovation Fund as the title. Two scientists featured: Katsuhiko Murakami, Ph.D., Pennsylvania State University, and Gene-Wei Li, Ph.D., Massachusetts Institute of Technology.

ALT Image of cells in blue with 2023 Pew Innovation Fund as the title. Two scientists featured: Katsuhiko Murakami, Ph.D., Pennsylvania State University, and Gene-Wei Li, Ph.D., Massachusetts Institute of Technology.

1
5
1
18
1,490
Bai Lab PSU retweeted
Shaun Mahony@mahonylab25 Oct 2023
Microbiology teaching faculty position at the Assistant or Associate Teaching Professor level is now open in the BMB Department at Penn State: psu.wd1.myworkdayjobs.com/PS…
8
5
1,811
Load more