Assistant Professor @UChicago | Previously @WhiteheadInst @BrighamWomens @UTSWNews. Condensate biology and disease.
Chicago, IL
Joined January 2015
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Salman Banani retweeted
Excited to share the first pre-print from our lab!!
Check it out here! biorxiv.org/content/10.64898…
We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Salman Banani retweeted
Excited to share my postdoc work with @JD_Buenrostro now out in @Nature!
"Epigenetic memory of colitis promotes tumour growth"
nature.com/articles/s41586-0…
We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵
Salman Banani retweeted
Why do some genetic mutations devastate specific tissues while sparing others?
We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain.
🧵 on our new paper in Science:
🔗 science.org/doi/10.1126/scie…
Salman Banani retweeted
On its 65 year anniversary, the story of the incredibly brave Frances Oldham Kelsey. A role model for competence, character and courage.
uchicagomedicine.org/forefro…
Salman Banani retweeted
ITOA is catching on
YAMANAKA FACTORS
Really interesting analysis and commentary based on some of @davidasinclair’s previous work.
Decent breakdown of how to think about slowing down aging, although, is very limited in scope (ie no mention of circadian biology, sleep, toxins, etc).
Salman Banani retweeted
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. cell.com/cell/fulltext/S0092….
Salman Banani retweeted
Riaz Gillani, MD, and @RyanLCollins13 in @VanAllenLab @DanaFarber report in @ScienceMagazine that rare germline genetic abnormalities increase the risk of pediatric solid cancers, findings that could help improve treatments and screening.
➡️ bit.ly/3BQ04hK
Salman Banani retweeted
Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility, which in turn reduces protein function. A new paper from @youngricka's lab describes this pervasive mobility defect: wi.mit.edu/news/cellular-tra…
Salman Banani retweeted
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1).
nature.com/articles/s41580-0…
Salman Banani retweeted
Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing.
biorxiv.org/content/10.1101/…
Salman Banani retweeted
#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. bit.ly/3MQjHIr @LaskerFDN
Salman Banani retweeted
Excited to share that our paper cell.com/molecular-cell/full… got the cover of the new issue of @MolecularCell. Extra cool that this is a photograph taken by the first author @Nancybrillet, a super-star research assistant and post-bacc who just started grad school @UTSWGradSchool
Salman Banani retweeted
Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .
Salman Banani retweeted
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
nature.com/articles/s41586-0…
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez
Salman Banani retweeted
Amazing review with very insightful analogies!
Highly recommended!
By @JAM_Bard and @dallandrummond.
Chaperone regulation of biomolecular condensates frontiersin.org/articles/10.…
Salman Banani retweeted
Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation.
science.org/doi/10.1126/scia…
Salman Banani retweeted
Excited to share my third piece of postdoc work from the @Transactivator lab! This is a collaborative work with @bsabari @mikayla_eppert. We show that coactivator condensates regulate cell lineage specification. science.org/doi/10.1126/scia…
Salman Banani retweeted
An 11th grade student from Westford MA asks: what are condensates? Thank you postdoc Alessandra Dall'Agnese for answering their question!
Our latest #AskaScientist video is published on BioNook, Whitehead Institute's online biology resource: wi.mit.edu/bionook/ask-a-sci…
