Raphael Isaac Benhamou (@BenhamouLab) header
Raphael Isaac Benhamou (@BenhamouLab) profile picture

Raphael Isaac Benhamou

@BenhamouLab

Chemical Biologist, Assistant Professor at the Hebrew University of Jerusalem, @hujimed. Postdoc in @disney_lab and Ph.D in @michafridman lab

 Jerusalem, Israel
benhamoulab.com
Joined July 2015
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Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)Photo by Raphael Isaac Benhamou (@BenhamouLab)
Raphael Isaac Benhamou retweeted
Guillaume Laconde (@Glaconde34) profile picture
Guillaume Laconde@Glaconde344 Sep 2025
Development of PROTAC-Based Strategies for Cannabinoid Receptor Type 1 (CB1R) Degradation in Cancer | ACS Pharmacology & Translational Science pubs.acs.org/doi/10.1021/acs…
Development of PROTAC-Based Strategies for Cannabinoid Receptor Type 1 (CB1R) Degradation in Cancer

Development of PROTAC-Based Strategies for Cannabinoid Receptor Type 1 (CB1R) Degradation in Cancer

Abstract. The cannabinoid receptor type 1 (CB1R), a key component of the endocannabinoid system (ECS), has been implicated in various oncogenic processes.

pubs.acs.org
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Raphael Isaac Benhamou retweeted
Nature Methods (@naturemethods) profile picture
Nature Methods@naturemethods2 Jun 2025
RNA structures are important too! In our latest Technology Feature, Michael Eisenstein explores how researchers are utilizing a growing toolbox of techniques to understand how RNA 3D structures inform their biological function. nature.com/articles/s41592-0…
Knowing when to fold ’em

Knowing when to fold ’em

Nature Methods - A steadily growing toolbox of techniques is helping researchers to understand the structural complexity that enables RNA molecules to perform a dizzying array of functions in the...

nature.com
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab5 Jun 2025
New in J. Med. Chem RiboTACs degrades LGALS1 mRNA by 97%, inducing apoptosis and blocking invasion in cancer models. Potency driven by linker + RNase L recruiter optimization PAL & NanoBRET confirm live-cell RNase L engagement pubs.acs.org/doi/10.1021/acs… pubs.acs.org/doi/10.1021/acs…
Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models

Abstract. A ribonuclease-targeting chimera (RiboTAC) is a heterobifunctional compound that binds to an RNA target and recruits a ribonuclease to cleave the

pubs.acs.org
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab23 Apr 2025
Noah built a platform to discover covalent small molecules that react with RNA. Many protein-reactive warheads also react with RNA. We then Converted a DNA binder into a rna covalent compound. Preprint: biorxiv.org/content/10.1101/… #RNA #CovalentDrugs #ChemicalBiology #DrugDiscovery
Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific...

Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific...

RNA is a key drug target that can be modulated by small molecules, however covalent binders of RNA remain largely unexplored. Using a high-throughput mass spectrometry screen of 2,000 electrophilic...

biorxiv.org
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Raphael Isaac Benhamou retweeted
Guillaume Laconde (@Glaconde34) profile picture
Guillaume Laconde@Glaconde349 Apr 2025
Advancing target validation with PROTAC technology: Expert Opinion on Drug Discovery tandfonline.com/doi/full/10.…
Advancing target validation with PROTAC technology

Advancing target validation with PROTAC technology

Targeted protein degradation (TPD) is a cutting-edge technology that provides new avenues for drug discovery and development. PROteolysis TArgeting Chimeras (PROTACs) are the most established and a...

tandfonline.com
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Raphael Isaac Benhamou retweeted
Pharmacy HUJI (@PharmacyHUJI) profile picture
Pharmacy HUJI@PharmacyHUJI10 Mar 2025
🚨We're Hiring! The School of Pharmacy seeks candidates for a tenure-track faculty position in Medicinal Chemistry! Please apply no later than August 31st, 2025 Apply now: ttp.ekmd.huji.ac.il/Pages/de… #Hiring #MedicinalChemistry #AcademicJobs #Pharmacy #HUJI
Image from Pharmacy HUJI (@PharmacyHUJI)
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Raphael Isaac Benhamou retweeted
Micha Fridman (@mifridm) profile picture
Micha Fridman@mifridm2 Mar 2025
Big thanks to Derek Lowe for the thoughtful commentary on our manuscript! Your insights on antifungal research and the challenges we face in drug discovery are invaluable. What the Antifungals Are Really Doing | Science | AAAS science.org/content/blog-pos…
What the Antifungals Are Really Doing

What the Antifungals Are Really Doing

What the Antifungals Are Really Doing

science.org
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab13 Feb 2025
Our latest RSC Chem Bio review explores RNA-targeted small molecule libraries—their evolution, design principles, and drug discovery potential. We also highlight key challenges, like the need for better datasets for AI-driven RNA therapeutics. pubs.rsc.org/en/content/arti…
Image from Matt Disney (@disney_lab)
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab14 Jan 2025
RNA: From Biology to Drug Discovery symposium, April 14-15, 2025, at UF Scripps. Speakers include: Darnell , Maquat, Rinn, Krainer, Krichevsky, and more! Register wertheim.scripps.ufl.edu/dep… #RNA #DrugDiscovery #Biology #UF #Scripps
RNA: From Biology to Drug Discovery 2025: Explore the therapeutic potential of RNA with thought...

RNA: From Biology to Drug Discovery 2025: Explore the therapeutic potential of RNA with thought...

World-class RNA scientists, experts in a wide variety of fields, assembled in Jupiter for the third biennial symposium, “RNA: From Biology to Drug Discovery 2025.” Hosted at the University of...

wertheim.scripps.ufl.edu
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab9 Dec 2024
We are very excited by this first disclosure of our large collaboration with the lab of Nikhil Munshi @DanaFarber using a cMYC mRNA degrader to affect Multiple Myeloma. ASH Annual Meeting sciencedirect.com/science/ar…
Image from Matt Disney (@disney_lab)
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Raphael Isaac Benhamou retweeted
Molecular Cell (@MolecularCell) profile picture
Molecular Cell@MolecularCell3 Oct 2024
Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell/issu…
Image from Molecular Cell (@MolecularCell)
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab25 Jul 2024
Congratulations, Yuquan (Hamish) Tong. We ID RNAs bound by small molecules in cells versus ones cleaved by recruiting ribonuclease effector proteins. Amir also developed a pipeline to use the binding data to predict 3D rna small molecule pockets in human rnas, a hard. problem
J. Am. Chem. Soc. (@J_A_C_S) profile pictureJ. Am. Chem. Soc.@J_A_C_S25 Jul 2024
Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras | Journal of the American Chemical Society @disney_lab @UFScripps @scrippsresearch #Transcriptome #Profiling #Ribonuclease #Chimeras pubs.acs.org/doi/10.1021/jac…
Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras

Transcriptome-Wide, Unbiased Profiling of Ribonuclease Targeting Chimeras

Abstract. Various approaches have been developed to target RNA and modulate its function with modes of action including binding and cleavage. Herein, we ex

pubs.acs.org
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab1 Jun 2024
We updated our methods to profile small molecule-RNA interactions (started 10 yrs ago), evolving to cellular transcriptome-wide, unbiased approaches. As further advances occur, they will be available as a preprint and at our lab's homepage biorxiv.org/cgi/content/shor…
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab20 Apr 2024
Heterobifunctional small molecules to modulate RNA function: Trends in Pharmacological Sciences …. Congratulations sandra and hamish (yuquan) and jess! cell.com/trends/pharmacologi…
Heterobifunctional small molecules to modulate RNA function

Heterobifunctional small molecules to modulate RNA function

RNA has diverse cellular functionality, including regulating gene expression, protein translation, and cellular response to stimuli, due to its intricate structures. Over the past decade, small...

cell.com
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Raphael Isaac Benhamou retweeted
Pharmacy HUJI (@PharmacyHUJI) profile picture
Pharmacy HUJI@PharmacyHUJI16 Apr 2024
Interested in research and aspiring to pursue a Master's or PhD degree? Join us on Thursday from 11:00 AM to 1:00 PM for the School of Pharmacy's Research Day! Discover groundbreaking research at the intersection of chemistry and biology! @HebrewU @Hujimed
Image from Pharmacy HUJI (@PharmacyHUJI)
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Raphael Isaac Benhamou retweeted
Postdoc in Israel (@PostdocIsrael) profile picture
Postdoc in Israel@PostdocIsrael11 Mar 2024
Attention international postdocs: Applications for the Azrieli International Postdoctoral Fellowship are now being accepted and are due by May 9! The Azrieli International Postdoctoral Fellowship supports the best and brightest minds in their postdoctoral research in Israel, connecting them with world-class academics and leading researchers. Please note that candidates are required to have an academic sponsor, who is a faculty member at an eligible Israeli academic institution. @azrielifdn
Photo by Shauli Lendner

ALT Photo by Shauli Lendner

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Raphael Isaac Benhamou retweeted
The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize2 Oct 2023
BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Image from The Nobel Prize (@NobelPrize)
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Raphael Isaac Benhamou retweeted
Gali Umschweif 💔🎗️ (@GUmschweif) profile picture
Gali Umschweif 💔🎗️@GUmschweif5 Sep 2023
A dream coming true: Thank you @ERC_Research for supporting my lab at @Hujimed! Come live the dream with us! We are recruiting postdocs with Ephys/bioinformatics skills to unlock the molecular basis of anxiety and depression comorbidity. Please RT!
Hebrew University (@HebrewU) profile pictureHebrew University
@HebrewU5 Sep 2023
Exciting news for @HebrewU! @ERC_Research grants 16.7M euros to 10 scholars for their groundbreaking researches. #HebrewU leads with the highest grant success rate in Israel! Congratulations to the receivers! #ERCGrants #HebrewUniversity shorturl.at/dhxXZ
Image from Hebrew University (@HebrewU)
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab10 Jul 2023
grateful to contribute this paper in memory on the incomparable Richard Lerner, the leader of scripps - RIP Richard! DNA‐Encoded Libraries and Their Application to RNA - Yang - Israel Journal of Chemistry - Wiley Online Library onlinelibrary.wiley.com/doi/…
DNA‐Encoded Libraries and Their Application to RNA

DNA‐Encoded Libraries and Their Application to RNA

The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and...

onlinelibrary.wiley.com
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Raphael Isaac Benhamou retweeted
Matt Disney (@disney_lab) profile picture
Matt Disney
@disney_lab26 Jun 2023
Congrats to team, J Bush @EricTWang, on platform to profile RNA binding small molecules transcriptome-wide. Study shows in Myotonic Dystrophy that augmenting binders as degraders can provide specificity beyond binder to improve disease defects. pubs.acs.org/doi/10.1021/acs…
Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp...

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp...

Abstract. Myotonic dystrophy type 1 (DM1) is caused by a highly structured RNA repeat expansion, r­(CUG)exp, harbored in the 3′ untranslated region (3′ UTR

pubs.acs.org
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