NCI K00 Fellow at UTSW in the Tagliabracci lab. Interested in cool enzymes and PTMs
Joined October 2019
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Benjamin Mayro retweeted
🧬 Big Data Phylogeny & Comparative Methods course (23–26 June, online)
Learn to build and interpret phylogenetic trees, analyse trait evolution, and apply comparative genomics to real data
physalia-courses.org/courses…
Benjamin Mayro retweeted
🧬Collinearity Analysis is here in #gbdraw v0.11.0! You can easily detect and visualize synteny and collinearity blocks using LOSATP. You can instantly align the entire diagram based on a shared ortholog!
Try it now: gbdraw.app/
#bioinformatics #genomics #microbiology
ALT Collinearity analysis of Hepatoplasmataceae, a group of mollicutes associated with isopod crustaceans. Inverted syntenic blocks are colored in dark red.
ALT Synteny of lividomycin-like aminoglycoside biosynthetic gene clusters. The diagrams are aligned based on livE gene (see next figure for the command)
ALT Dialog box for the livE gene in the record BGC0000708. Click "Align" to align the records based on the shared livE orthologs, as seen in the previous figure.
Benjamin Mayro retweeted
📣Nominations are now open for the following awards:
-Outstanding Postdoc at Duke (nominate here: duke.qualtrics.com/jfe/form/…)
-Outstanding Postdoc Mentor at Duke (nominate here: duke.qualtrics.com/jfe/form/…)
Deadline to nominate: 9/10/25 at noon
More info: research.duke.edu/postdoc/aw…
Benjamin Mayro retweeted
Read the paper featured on the cover of this month’s Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State brnw.ch/21wR7NC By Shane Killarney, @kcw00d, and colleagues @Duke_PCB @DukeCancer
Benjamin Mayro retweeted
An accomplished scientist who studies the role of protein tyrosine kinases, Ann Marie Pendergast, PhD, finds mentoring easy because she focuses on it full time. She meets weekly with students in her lab and outside of that, her office is always open.
pcb.duke.edu/news/mentor-spo…
Benjamin Mayro retweeted
Exciting findings in a study led by Shane Killarney in the @kcw00d lab: Mesenchymal-like cancer cells depend on PKN2 kinase for survival, offering a potential therapeutic target against drug resistance. A cool collaboration with the Pendergast and McDonnell labs ⬇️ @DukeCancer
Now online in @CD_AACR: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, @kcw00d, and colleagues doi.org/10.1158/2159-8290.CD… @Duke_PCB
Benjamin Mayro retweeted
I'm excited to announce that I've accepted a TT faculty position @VanderbiltCDB and @VUMC_Cancer! Thrilled to join @VanderbiltU!
The Mudumbi Lab opens January 2025. We will use single-molecule microscopy to study the kinetics of RTK signaling, with a focus on biased signaling!
ALT Man standing in front of a wall with the Vanderbilt seal arms crossed.
Benjamin Mayro retweeted
A farewell to our fantastic colleague, Jamie Baize Smith @katbaizes. The PCB students, staff and faculty thank you and we wish you all the best in your next chapter.
Benjamin Mayro retweeted
Are you ready for unpublished research on protein kinases and phosphorylation plus a gorgeous view of the Irish Coast? Join @bradylabupenn, @Megston8, @mbyaffe, and Vincent Tagliabracci @UTSWScience for this great program and save your space at #PPHSRC: hubs.ly/Q02v5Hs20
Benjamin Mayro retweeted
Current protein models (ESM-2, AlpaFold2,...) only encode the 20 wild-type amino acids -- what about PTMs, which significantly influence the diversity of the proteome? 💁♂️To solve this, we present the first PTM-aware protein language model, PTM-Mamba! biorxiv.org/content/10.1101/…
Benjamin Mayro retweeted
Nice report by Keith Caldecott: Causes and consequences of DNA single-strand breaks: Trends in Biochemical Sciences cell.com/trends/biochemical-…
Benjamin Mayro retweeted
Our paper discovering short linear motifs #SLiMs targeted by the MAP kinases ERK and p38 is now published! Led by the incomparable Jaylissa Torres Robles, this paper resolves how these two related kinases selectively target unique substrates.
pnas.org/doi/10.1073/pnas.23…
Benjamin Mayro retweeted
It is not fresh to know that γ-secretases process APP to generate Aβ. But what do they cut in microglia? Why do they cut so many proteins in the meantime? Our paper just published in @MolecularCell provides new insights on these topics. Check it out: cell.com/molecular-cell/full…
Benjamin Mayro retweeted
PCB Dissertation Seminar
Breast cancer cells exhibit a non-linear proliferative dose response to progestins
Presented by: Emma Dolan
Advisors: Drs. Donald McDonnell & Susan Murphy
Friday, October 27 at 9:00am
LSRC A247
Benjamin Mayro retweeted
🍹NEW:@ArdehaliHossein & co find a role for the #HistoneDemethylase KDM3B in sensing #ironlevels and regulating #mTORC1 via #transcriptional repression of mTORC1 pathway components. @nu_fcvrri @NUFeinbergMed @NorthwesternMed @NUMSTP
rdcu.be/dnhYk
nature.com/articles/s41556-0…
Benjamin Mayro retweeted
Ok, Twitter, prove you are still useful: Tell me when and by whom Oct3/4, Sox2, Klf4, c-Myc were each first cloned/described?
@matthewcobb
@AMartinezArias
@gastrulateordie
@MadS100tist, an RT is appreciated.
Benjamin Mayro retweeted
Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping dlvr.it/SwTj6W
Benjamin Mayro retweeted
The Department of Pharmacology & Cancer Biology is hiring! We are looking for candidates with research interests in the broad area of cancer biology (from fundamental mechanisms to translational applications). Read more about the search and apply here: pcb.duke.edu/news/tenure-tra…
Benjamin Mayro retweeted
Our new work in @Nature to explain how retrotransposons synthesize the 2nd-strand DNA by a circularization process.
Story: made some cool findings (we thought) -> actually scooped 40-yr ago by textbook knowledge -> textbook appear to be incorrect. nature.com/articles/s41586-0…
