@Beroldak

🇲🇽 MD, PhD Student Weizmann institute, Hanna Lab

 ישראל
Joined June 2012
  • Tweets39
  • Following87
  • Followers72
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Bernardo Oldak retweeted
Cell Stem Cell@CellStemCell7 Aug 2025
Online Now! Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs dlvr.it/TMMGMW #stemcells

Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and...

Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows...

cell.com
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We truly enjoyed summarizing this tour de force work in @Dev_Cell on understanding human cleavage stage ZGA arrest by using single-embryo single-cell allele-specific RNA-seq by Peng Yuan team, & catching up on other recent advancements in ZGA research cell.com/developmental-cell/…
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Científicos del Instituto Weizmann de Ciencias buscar comprender los enigmas del embrión humano dentro del útero - Infobae infobae.com/salud/ciencia/20…

Científicos del Instituto Weizmann de Ciencias buscar comprender los enigmas del embrión humano...

Bernardo Oldak y Angel Polanco, científicos mexicanos del Departamento de Genética Molecular del laboratorio del profesor Jacob Hanna, hablaron con Infobae sobre sus investigaciones en medicina...

infobae.com
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Excellent account of the evolution of models of human embryos for the last 150 years. N. Hopwood shorturl.at/4Dbdf Journey through the landmarks of human embryology and its representations. Yes, #EmbryoModels is not something we have just run into #MustRead #HistoryMatters
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Proud to see that our work made it to @TIME 2023 best inventions on the experimental category. Thanks to all Hannalab members @jacob_hanna for this ongoing journey.
Jacob (Yaqub) Hanna - يعقوب حنا
@jacob_hanna24 Oct 2023
Moment of escapism: Hanna lab human complete embryo model (SEM) made it to @TIME 2023 best inventions. "Find out why Human Embryo Model is one of TIME's best inventions of 2023 ti.me/3sahgtp " Kudos to @Beroldak who led this effort @Nature nature.com/articles/s41586-0…
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Bernardo Oldak retweeted
nature
@Nature20 Oct 2023
This week in Nature: Embryo models - stem cells form structures that mimic two-week-old human embryos Browse the current issue: nature.com/nature/volumes/62…
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Moment of escapism for us: Hanna lab developed human complete and structured embryo model (SEM) made it to the cover of today's @Nature issue: nature.com/nature/volumes/62… Thanks @maayanvisuals for graphics! In print final paper version: nature.com/articles/s41586-0…
Jacob (Yaqub) Hanna - يعقوب حنا
@jacob_hanna6 Sep 2023
📣 Our fun journey continues - latest lab preprint is now out in @Nature Check out in great detail how we derive Complete and Structured human day 14 post-implantation embryo models (SEMs) solely from unmodified HENSM naïve ESCs @Beroldak @EmilieWildschu1 @vlad_bndk @noashefi nature.com/articles/s41586-0…
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Thanks @nmoris for insightful N & V @Nature in which u also invested in making an figure that reflects the very different structures in the 3 papers covered, including our own. Stem cells used to model a two-week-old human embryo nature.com/articles/d41586-0…
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This new paper in nature has a Protocol Exchange protocol associated with it: Complete human day 14 post-implantation embryo models from naïve ES cells nature.com/articles/s41586-0… Generation of ... Structured Embryo Models (SEM) protocolexchange.researchsqu…

Complete human day 14 post-implantation embryo models from naive ES cells

Nature - The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up...

nature.com
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Bernardo Oldak retweeted
Noticias CMM@CMM_noticias7 Sep 2023
🧪 #Investigación | Científicos israelíes desarrollan embriones sintéticos a partir de células madre cultivadas en laboratorio, sin óvulos ni esperma. Los embriones han llegado hasta el día 14 fuera del útero materno. @WeizmannScience @jacob_hanna
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Bernardo Oldak retweeted
nature
@Nature6 Sep 2023
Nature research paper: Complete human day 14 post-implantation embryo models from naïve ES cells go.nature.com/3Ps6sjh

Complete human day 14 post-implantation embryo models from naive ES cells

Nature - The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up...

nature.com
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Weizmann Institute of Science researchers have created complete models of human embryos from stem cells for the first time! Today, this groundbreaking research by Prof. @Jacob_Hanna’s team at the Molecular Genetics Department was published in the scientific journal @Nature (1/4)
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A @Nature paper presents a model of the human embryo from implantation into the uterus to 14 days after fertilization, generated from genetically unmodified pluripotent stem cells. go.nature.com/3Z3qljX
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📣 Our fun journey continues - latest lab preprint is now out in @Nature Check out in great detail how we derive Complete and Structured human day 14 post-implantation embryo models (SEMs) solely from unmodified HENSM naïve ESCs @Beroldak @EmilieWildschu1 @vlad_bndk @noashefi nature.com/articles/s41586-0…
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Happy to see our paper on @Nature Thanks to all Hannalab crew nature.com/articles/s41586-0…

Complete human day 14 post-implantation embryo models from naive ES cells

Nature - The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up...

nature.com
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Bernardo Oldak retweeted
NYT Science
@NYTScience24 Jun 2023
Four teams have coaxed human stem cells to organize themselves into embryo-like forms. The advance could shed light on fertility. nyti.ms/43WvuvO

Scientists Debut Lab Models of Human Embryos (Published 2023)

Four teams have coaxed human stem cells to organize themselves into embryo-like forms. The advance could shed light on fertility.

nytimes.com
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Biologists trying to create laboratory models of the early growth of a human embryo have taken a major step forward. scim.ag/32S

Biologists create detailed lab replicas of early human embryos

Grown from stem cells, mock embryos recapitulate development beyond implantation stage

science.org
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Yes, the model by @jacob_hanna is probably the model that gave me the most important uncanny feeling so far because the resemblance to the human embryo is so remarkable - as I also commented in press. However, it’s still a model, as the authors also point out (4/n)
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Overjoyed by the incredible journey! thanks to the amazing team! @EmilieWildschu1 @vlad_bndk @jacob_hanna and all Hanna lab members biorxiv.org/content/10.1101/…
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Together, we’ve successfully created a synthetic embryo model, featuring the major cell populations during post-implantation stages, forming a truly remarkable architecture! Excited to share our findings with the scientific community for valuable feedback.
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Here and example of one of the first human SEMs we were found
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