PI & Head of the "Tumour Environment & Pituitary Oncology" team @ INSERM
CRCL Lyon-France
Joined September 2021
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Philippe Bertolino retweeted
What is a PhD?
Open Access
embopress.org/doi/full/10.10…
#PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science
Philippe Bertolino retweeted
#Senescence #SpatialTranscriptomics Skin Wound Healing
P21-high cell clearance⏫ full-thickness skin wound healing🐭(till D12)
⏬Dermal fibroblast
⏬Collagen deposit
#Xenium
p21-CreERT2::tdT::DTA🐭
p21-high (tdT+) cells are induced & constitute 7% (mainly fibroblasts #EndothelialCell M1Mφ granulocyte/lymphoid cell) of all wounded skin cells
vs p16-hi cells▶️only 0.5% cells
p21-hi cells are all enriched in transcripts of PDGFA (similar to previously reported p16-hi cells in wounded skin) MMPs TGFb1/3 MCP1 MIP2 +⏫#DNADamage ⏫1.7-fold cell size
vs p16-hi cells have a distinct transcript profile
Any impact of p21 cell clearance on #HairFollicle regeneration?😆
@MingXuUCHC @NatureAging 2024
nature.com/articles/s43587-0…
xitter.cf/NatureAging/status/185…
Online now!✨RESEARCH: Gasek, Yan, Zhu et al explore the heterogeneity of senescence in wound healing. Using spatial transcriptomics, they identify a p21-high population with detrimental consequences @MingXuUCHC nature.com/articles/s43587-0… rdcu.be/dZ1C6
Philippe Bertolino retweeted
from bench to bedside to restaurant ..... @HCL_research @crcl @Bertolino_Lab #Pituitary translational research group with our guest @elisalamback from @gadelha_monica 's Lab
#EmmanuelJouanneau our pituitary neurosurgeon expert is missing (resting)
Philippe Bertolino retweeted
🚨 Rappel ! En attendant la remise des prix, nous vous rappelons que vous pouvez proposer vos idées d'acronyme et vous inscrire pour le nouveau groupe jeunes en endocrinologie. Scannez les QR codes sur l'affiche ⬇
Philippe Bertolino retweeted
"Occasionally, you work with people that you cannot, in all honesty, recommend to move on to the next stage of their research career. How do I tell someone that I can't write them a strong letter of recommendation?" go.nature.com/3Yb8uY5
Philippe Bertolino retweeted
Another excellent #ECE2024 @ESEndocrinology meeting
Both our clinical @CRMR_HypoLyon @HCL_research and research #pituitary departments @crcl @Bertolino_Lab are greatly represented
Philippe Bertolino retweeted
We are now recruiting students to join the Master 2 Cancer Bioengineering in Lyon. For biologists or physicians wishing to move towards interdisciplinarity. tinyurl.com/4mpxe57a Registrations now open : ecandidat.univ-lyon1.fr Do not hesitate to contact me for more info.
Philippe Bertolino retweeted
Excited to be part of this excellent @EYEScientists @ESEndocrinology initiative with @Bertolino_Lab waiting for #pituitary lovers !!
📣 Exciting news you’ve all been eagerly awaiting: The EYES Observership Programmes 2024 application is now OPEN, unlocking doors to transformative opportunities! 🚀
Apply now! tinyurl.com/5bsazwh2
@ESEndocrinology @EsePresident @EUWIN_ESE
🧵1/3
We are currently looking for a PhD candidate to join the team.
Details are bellow :
doctorat.campusfrance.org/CF…
Philippe Bertolino retweeted
New content online: Pituitary stem cells: past, present and future perspectives dlvr.it/T0BG3c
Philippe Bertolino retweeted
GitHub - omnideconv/spacedeconv: A unified interface to spatial transcriptomics deconvolution tools github.com/omnideconv/spaced…
Philippe Bertolino retweeted
Our DARLIN paper is out. We hope that this model really enables and facilitates single cell lineage tracing experiments in the mouse. Thanks specially to @Li_Li_666 and @ShouwenW. More exciting uses of the technology coming out soon...
cell.com/cell/fulltext/S0092…
Philippe Bertolino retweeted
Long-read whole-genome analysis of human single cells | Nature Communications nature.com/articles/s41467-0…
Philippe Bertolino retweeted
I was wondering if sc3D was able to register and display the crazy data from doi.org/10.1016/j.cell.2022.…. Here is the result with some Hox genes🤓 (showing downsampled data).
sc3D➡️github.com/GuignardLab/sc3D
➡️@AbhiSampKumar, @adrianobolondi, @Luyi_T et al.: nature.com/articles/s41588-0…
Philippe Bertolino retweeted
When you tell a bioinformatician that they can now run wetlab experiments on their own
Building preclinical models at @cermep and @crcl…. Super excited to image the longitudinal progression of tumour cells we grafted in mouse pituitaries
@GeraldRaverot et @Bertolino_Lab , #pituitary, #MRI
Philippe Bertolino retweeted
Today I have published a guide that introduces some of the key concepts of napari - a multi-dimensional image viewer for Python. Thanks to @martinjones78 and @haesleinhuepf for their helpful feedback.
medium.com/@matous.elphick/n…
Philippe Bertolino retweeted
Spatial profiling technologies illuminate the tumor microenvironment dlvr.it/SksxwR
Philippe Bertolino retweeted
Spatial epigenome–transcriptome co-sequencing🤩🤩🤩Beyond excited to see it out today @Nature! Enjoyable collaboration between my lab @YaleBME @YaleSEAS @YaleMed and @GoCasteloBranco of @karolinskainst. The most informative tool for spatial multi-omics!!
nature.com/articles/s41586-0…
