Postdoc @RockefellerUniv l O’Donnell Lab l DNA replication, repair, & single-molecule biophysics
Manhattan, NY
Joined February 2020
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- Following359
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Gabriella Chua retweeted
Congrats to TPCB alum Dr. Chen Chen, who has been named a 2026 STAT Wunderkind for his postdoctoral research at @genentech!
linkedin.com/posts/genentech…
Gabriella Chua retweeted
TPCB’s Gabriella Chua, PhD and colleagues in the Liu, O’Donnell, & Zhao labs at Rockefeller and MSK found that RFC, the clamp-loader protein that installs PCNA onto DNA, doesn’t detach and move on as believed—it rides along with PCNA during DNA replication bit.ly/TPCBnews
Gabriella Chua retweeted
Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @Nature
nature.com/articles/s41586-0…
Gabriella Chua retweeted
Huge congratulations to the recipients of the 2026 Weintraub Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. fredhutch.org/en/news/releas…
ALT Top row, left to right: Keene Abbot, Gabriella Chua, Lifei Jiang, Won Jun Kim, Ruchita Kothari and Ayush Midha. Bottom row, left to right: Rohith Rajasekaran, Yusha Sun, Andrea Terceros, Wendy Valencia Montoya, Zachary Walsh and Peter Yoon.
Gabriella Chua retweeted
Very excited to share our latest preprint, where we visualize the impact of force on the catch bonding actin crosslinker α-actinin-4. Led by @alfredcchin, a great collaboration with Glen Hocky's lab.
biorxiv.org/content/10.64898…
Gabriella Chua retweeted
Nucleosome spacing regulates linker methylation by DNMT3A2/3B3 dlvr.it/TRL46G
Gabriella Chua retweeted
Now online! A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis dlvr.it/TQgqVG
Gabriella Chua retweeted
A study in @CellCellPress from Shixin Liu (@InLiuOfBulkExps) and Michael O’Donnell finds that a protein once thought to simply help load a factor necessary for the copying of DNA actually plays a key role in ensuring fast and reliable replication: bit.ly/4qOodK1
Gabriella Chua retweeted
Check out our paper @CellCellPress where we visualized the interplay between two key DNA replication factors PCNA & RFC and found an unexpected non-catalytic role of RFC in stabilizing PCNA’s interaction with DNA polymerase and enabling efficient synthesis cell.com/cell/fulltext/S0092…
Gabriella Chua retweeted
Our work on single-molecule visualization of mammalian transcription elongation is online @NatureSMB today! Check out the open-access paper rdcu.be/eR257 to see how Pol II acts as a multi-speed machine🚗We are thankful for our collaborators @RockefellerUniv @FudanUniv🙏
Gabriella Chua retweeted
Vostal et al @KapoorLab_RU @RockefellerUniv report two structures of complexes formed by VCP, an unfoldase, & VCPIP1, a deubiquitinase, & suggest that VCPIP1 is poised to cleave #ubiquitin from protein substrates that translocate through VCP’s central pore hubs.la/Q03bV3G00
Gabriella Chua retweeted
Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in @ScienceAdvances : bit.ly/3EFpD6h
Gabriella Chua retweeted
Scientists in the @Alushin_Lab have figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for metastasis. #RockefellerScience
bit.ly/3PKErmA
Gabriella Chua retweeted
Very happy to share our new review in @MolecularCell covering nucleic acid recognition and effector mechanisms for various prokaryotic immune systems! Was a great experience creating this with @MarraffiniLab!
cell.com/molecular-cell/full…
Gabriella Chua retweeted
Using the @LUMICKS C-Trap, the lab of @InLiuOfBulkExps provided unprecedented, real-time insights into the binding behavior of MeCP2, a protein linked to Rett syndrome, across methylated and unmethylated DNA and nucleosomes.
lumicks.com/revealing-mecp2-…
Gabriella Chua retweeted
Absolutely thrilled to share our new study, co-led by @PujaMajumder91 and myself, now online in @CellCellPress! Here, we characterize a CRISPR-associated adenosine deaminase, Cad1. Incredibly grateful for @MarraffiniLab making it possible. Synopsis below:
cell.com/cell/fulltext/S0092…
Gabriella Chua retweeted
Congratulations to Christian Baca @ChristianF_Baca in the Marraffini lab on being recognized by the Max Birnstiel Foundation and Research Institute of Molecular Pathology @IMPvienna with an Honourable Mention for the 2024 International Birnstiel Awards!
linkedin.com/posts/tpcb_chri…
Gabriella Chua retweeted
We are pleased to share our latest preprint on bioRxiv! Led by graduate student @VostalLauren, we use chemical proteomics to profile VCP-DUB interactions in living cells. We identify DUBs that bind the entry, exit, or both sites of VCP's central pore.
biorxiv.org/content/10.1101/…
Gabriella Chua retweeted
New findings from @InLiuOfBulkExps provide insight into a master regulator of gene expression, and could open up new avenues for Rett syndrome therapies. #RockefellerScience
rockefeller.edu/news/36409-n…
Gabriella Chua retweeted
Our paper on MeCP2 is now published @NatureSMB ! rdcu.be/dRqUn Read the Research Briefing rdcu.be/dRLZf or tweetorial from @BadAtCloning 👇for a summary of the study. And big thanks to the reviewers and editors for their efforts on improving our manuscript.
