@BioSyn
Joined June 2020
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  • Following69
  • Followers14
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Our manuscript on Promoter Calculator was published today in @NatureComms! Many thanks to @bioalgorithmist and @hsalis for helping to complete the project. Debug genetic systems and forward engineer new promoter sequences. Read more here: nature.com/articles/s41467-0…

Automated model-predictive design of synthetic promoters to control transcriptional profiles in...

Nature Communications - Transcription rates are regulated by the interactions between RNA polymerase, sigma factor, and promoter DNA sequences in bacteria. Here the authors combine massively...

nature.com
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Most-read analytica news: 🆕 drug candidates identified in bacteria which show great promise as a source of active ingredients analytica-world.com/en/news/… @Microbio_ETH @ETH_DBIOL @ETH_en @HubrichFlorian @BoeschNinaMaria @Michael11Rust @serina_robinson @AnnaVagstad @piel_lab
📸 qimono/ pixabay Licence

ALT 📸 qimono/ pixabay Licence

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It’s a good thing if #animaltesting is widely discussed in society, but it’s important that these discussions are fair and fact-​based, says Detlef Günther in the current #Zukunftsblog. ethz.ch/en/news-and-events/e…

We should talk about animal testing

It’s a good thing if animal testing is widely discussed in society, says Detlef Günther, but it’s important that these discussions are fair and fact-based.

ethz.ch
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If you're overexpressing a protein and you get like *nothing*, please check for repetitive DNA sequences! ⚠️This⚠️happens⚠️all⚠️the⚠️time⚠️
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Alpha-fold says this is possible. Thoughts? 😆
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A big thank you to @ChEnected for promoting biotechnology entrepreneurship among chemical engineering faculty and for the wonderful Langer Prize award, named after living legend @MITChemE prof Bob Langer finance.yahoo.com/news/aiche… (1/2)
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In work led by @StorkDevon & in collaboration between @fleshball & @geochurch, we report site-specific incorporation of a variety of non-standard amino acids in Bacillus subtilis for several purposes including interrogation of bacterial cytokinesis. Now out in @NatureComms (1/2)
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Excited to share this is my first full week starting as a #newPI of the Microbial Specialized Metabolism group, @EawagResearch🧪 🧬 🧫 Feeling extra grateful for this past year @ETH in the amazing @piel_lab and looking forward to getting to know new colleagues! – at Zurich, Switzerland
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Research tip: don’t scroll through color palette databases hoping to find the perfect one for your fig. Just copy the sprite of your favorite Pokémon into PowerPoint, select the eyedropper tool, and…
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Pubmed: A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design dlvr.it/S6H78P
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Whoa 🤯 Nanopore-based protein sequencing
Cees Dekker@cees_dekker14 Jul 2021
Today we released a preprint biorxiv.org/content/10.1101/… where we take a step towards the next challenge: building a nanopore single-molecule PROTEIN sequencer! 😳 Awesome experiments by postdoc Henry Brinkerhoff of our #CDlab, augmented with MD simulations of @aksimentievLab 1/x
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Pairs well with
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I am absolutely THRILLED to announce I will be joining @UWChemE as an assistant prof starting Jan 2022. My group (located in NanoES) will work at the interface of chemistry/biology and look to engineer life for making biomolecules with enhanced function. A small thread here (1/6)
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Now in PNAS with a few extra goodies, for the afficionados: pnas.org/content/118/18/e201…

High-throughput functional variant screens via in vivo production of single-stranded DNA | PNAS

Creating and characterizing individual genetic variants remains limited in scale, compared to the tremendous variation both existing in nature and ...

pnas.org
Schubes@Schubes06 Mar 2020
Excited to share our pre-print, describing using ssDNA made inside cells to perform new types of high-throughput screens in bacteria! With @dbgoodman @TimWannier @Divjot123 Fahim Farzadfard @timlu @seth_shipman @geochurch (science thread, if you care) biorxiv.org/content/10.1101/…

High throughput functional variant screens via in-vivo production of single-stranded DNA

Tremendous genetic variation exists in nature, but our ability to create and characterize individual genetic variants remains far more limited in scale. Likewise, engineering proteins and phenotypes...

biorxiv.org
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If you have the slightest interest in synbio, subscribe to the Cell Crunch newsletter RIGHT NOW! Don't miss out on tomorrow's synbio breakthroughs - @NikoMcCarty is KILLING IT! cell.substack.com/
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Nature Biotechnology papers xitter.cf/HolyCow_Inc/status/136…
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Ready for a protocol to guide the computational mapping of phenotypes to bottleneck cellular (linked to metabolism) processes?? Stay tuned! 😱🙃🙂 #genotypephenotype #geneticscreens #omicsdata #conditionalessentiality #metabolism #metabolicmodeling #isthispossible
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Students are welcome to apply from *any* continent, county and all stages of their pre-postdoc carrier! 🇪🇺 🇺🇸 🇨🇳 🇦🇺 🇬🇧 🇩🇰... – at Boston, MA
Akos Nyerges@AkosNyerges30 Dec 2020
Internship opportunity for 2021 in #SynBio and #DirectedEvolution 🧑‍🎓 Come and work with @geochurch @AnushChP and me at @harvardmed on the to-date largest scale bacterial genome & genetic code engineering project. Thank you for RTs! Candidates: Feel free to DM or email me.
Construction of rEcoli-57.

ALT Construction of rEcoli-57.

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Our review on synthetic genomes with altered genetic codes is out! doi.org/10.1016/j.coisb.2020… Many thanks to Nili, @geochurch, @AkosNyerges, Ali, and Max! #synbio
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This was both fun & a great learning experience with the talented @SyntBio @mpsmela1 @BioSyn. TBDB is a work in progress & we hope to keep engaged with the community to improve it. Also wonderful experience with @NAR_Open, -the reviews constructive & improved the manuscript a lot
Jorge Marchand@SyntBio8 Sep 2020
Excited to announce our T-box riboswitch database paper is now available at NAR @NAR_Open! These riboswitches sense aminoacylation of tRNAs in vivo. You can browse the database at tbdb.io #tRNA #Tbox #riboswitch doi.org/10.1093/nar/gkaa721
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