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BCB-Faller Group

@BiochemMetal

Biometals and Biological Chemistry (BCB) Lab, Pr. Peter Faller Group, @unistra

 Strasbourg
bcb.chimie.unistra.fr/
Joined April 2021
  • Tweets78
  • Following251
  • Followers424
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc129 Jun 2024
Check out our pre-print about the impact of lysosomal pH on the pro-oxidant and anticancer activity of the Cu-Phenanthroline complex @ChemRxiv go.shr.lc/4cEkVkN @BiochemMetal @PROMOCSlab @MedUni_Wien @esrfsynchrotron
Image from Enrico Falcone (@EnriFalc1)
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc124 Jun 2023
Check out in @Metallomics my first paper as sole corresponding author, about the redox activity of Copper with biological reductants and its biological implications for therapeutic purposes @BiochemMetal @IlbertMarianne Thanks to @UniofNottingham for OA doi.org/10.1093/mtomcs/mfad0…

Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine, and glutathione

Abstract. Copper (Cu) is essential for most organisms, but it can be poisonous in excess, through mechanisms such as protein aggregation, trans-metallation

academic.oup.com
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc16 Mar 2023
Thanks to a collaboration between @BiochemMetal @unistra and the group of Prof. Silvia Morante @unitorvergata, we characterized a key redox intermediate of the Copper-Amyloidβ complex by XAS at @esrfsynchrotron. Now Open Access in @angew_chem onlinelibrary.wiley.com/doi/…
Chasing the Elusive “In‐Between” State of the Copper‐Amyloid β Complex by X‐ray Absorption through...

Chasing the Elusive “In‐Between” State of the Copper‐Amyloid β Complex by X‐ray Absorption through...

The combination of X-ray induced photoreduction and thermal relaxation unravels the structure of an intermediate of the CuII/CuI Aβ1–16 redox cycling. The X-ray beam promotes CuII reduction to CuI...

onlinelibrary.wiley.com
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc124 Jan 2023
Interested in the interaction of labile metal ions and chelators in the blood? Check out @DaltonTrans (OA doi.org/10.1039/D2DT03875G) where we (@BiochemMetal) introduce the concept of pM(plasma) to take into account the real concentrations of plasma proteins and metals in the blood
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New paper on the Ala-His-His peptide as an appropriate scaffold to remove and redox silence copper ions from the Alzheimer's-related Abeta peptide ! @Biomol_MDPI Check it out: doi.org/10.3390/biom12101327
Image from Alzheimer, Amyloids and Bioinorganic Chemistry (@HureauLab)
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BCB-Faller Group retweeted
J. Am. Chem. Soc. (@J_A_C_S) profile picture
J. Am. Chem. Soc.@J_A_C_S7 Aug 2022
Cu-Catalyzed Glutathione Oxidation Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Boosted at Lower pH @MedUni_Wien @UniCalPortale @unistra @reseauSCF @BiochemMetal #Cu #Glutathione #Oxidation #Thiosemicarbazone #Booster #Anticancer #Cancer pubs.acs.org/doi/10.1021/jac…
Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT...

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT...

Abstract. Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of

pubs.acs.org
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc16 Aug 2022
So glad to see our work just published in @J_A_C_S! This is the result of an interdisciplinary and international collaboration between @BiochemMetal @PROMOCSlab @PetraHellwig2 @KowolLab @MedUni_Wien. Thanks to @FWF_at for funding open access. Check it out pubs.acs.org/doi/10.1021/jac…
Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT...

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT...

Abstract. Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of

pubs.acs.org
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#MBP2022 International Conference on Metal-Binding Peptides : Methodologies and Applications 1ère conférence internationale sur les #peptides liant les #métaux 🗓️ 5-8 juillet 2022 à #Nancy Organisée par le #LRGP et @BiochemMetal En savoir plus👉 empp.univ-lorraine.fr/mbp202…
Image from Pôle Scientifique EMPP (@EmppPole)
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc120 May 2022
Check out our #preprint on @ChemRxiv about the surprisingly faster glutathione oxidation at lower pH catalysed by an anticancer Cu-complex. doi.org/10.26434/chemrxiv-20…

Copper-catalysed glutathione oxidation is accelerated by the anticancer thiosemicarbazone Dp44mT...

Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining the redox state of many biomolecules, in detoxification and in antioxidant defence. The thiols...

chemrxiv.org
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BCB-Faller Group retweeted
Dorlet Pierre (@DorletP) profile picture
Dorlet Pierre@DorletP19 May 2022
Good news Olga Iranzo and I just got a PhD funding from Region PACA to work on therapeutic Cu complexes. Drawback we need a good candidate urgently (by May 24th…) Any good and motivated Master student out there interested ? Please RT
Image from Dorlet Pierre (@DorletP)
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BCB-Faller Group retweeted
BIP6 - CNRS (@BIP6_Marseille) profile picture
BIP6 - CNRS@BIP6_Marseille26 Apr 2022
Registration to the 3rd FrenchBIC summer school on methods to study metals in biology is now open. Great program. Great teachers. Great place. Low fees. frenchbic.cnrs.fr/metbio2022
Image from BIP6 - CNRS (@BIP6_Marseille)
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BCB-Faller Group retweeted
Y V SUSEELA (@yvsuseela) profile picture
Y V SUSEELA@yvsuseela22 Apr 2022
ACS Bio & Med Chem Au pubs.acs.org/toc/abmcb8/2/2#… Dual targeting activity of G-quadruplex binding small molecules for synergistic arrest of oncogene overexpression and rRNA biogenesis.
Image from Y V SUSEELA (@yvsuseela)
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Copper 2022 registration is open! Links for registration, abstract submission, and accommodations are now available at sites.northwestern.edu/coppe…. Excited to be moving ahead with the conference!
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The annual meeting of the @DCC_SCF statuts now in Lille with our president Stéphane Bellemin-laponnaz
Image from Coordination Chemistry Division SCF (DCC-SCF) (@DCC_SCF)
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BCB-Faller Group retweeted
Christian Kowol (@KowolLab) profile picture
Christian Kowol@KowolLab6 Apr 2022
Congrats to Philipp and Michi and thanks for the great collaboration with @WalterBerger19. Our newst highly interdisciplinary paper on novel Pt(IV) prodrugs in Comm. Chem. nature.com/articles/s42004-0…
A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

Communications Chemistry - Platinum(IV) complexes have the potential to overcome several limitations and reduce adverse effects of platinum-based cancer therapy. Resistance to clinically approved...

nature.com
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Thanks to @BiochemMetal for hosting me! So excited to join you soon!
BCB-Faller Group (@BiochemMetal) profile pictureBCB-Faller Group@BiochemMetal30 Mar 2022
We're happy to host Liliana Quintanar @lilquintanar as the speaker of our weekly seminar (Friday 10.30 am) at the Institut de Chimie @unistra. Looking forward her talk about "Copper-protein interactions in degenerative diseases: From the brain to the human lens".
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BCB-Faller Group retweeted
Greg Nocton (@GregNocton) profile picture
Greg Nocton@GregNocton9 Feb 2022
Go and Check our international Summer School on f-elements in Aussois, France, June 12-16 2022. A friendly atmosphere for about 40 attendees! Pre-registration are now open. Visit our website felements.fr/cs2fe-2022/ @Centra_felement
Image from Greg Nocton (@GregNocton)
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Huge congrats to @IlbertMarianne's group for this cool @mbiojournal paper on copper inducing protein aggregation in E. coli as a mechanism of toxicity. journals.asm.org/doi/10.1128…
Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones | mBio

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones | mBio

With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular...

journals.asm.org
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Happy to share our latest study on copper-induced protein aggregation, published in @mBio, with great collaborators @dana_reichmann, @GenevauxPierre, Peter Faller lab @BiochemMetal and others not on twitter. journals.asm.org/doi/10.1128…
Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones | mBio

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones | mBio

With the increase of antibiotic drug resistance, alternative antibacterial treatment strategies are needed. Copper is a well-known antimicrobial and antiviral agent; however, the underlying molecular...

journals.asm.org
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BCB-Faller Group retweeted
Enrico Falcone (@EnriFalc1) profile picture
Enrico Falcone@EnriFalc117 Mar 2022
I'm very glad and honoured to have been awarded the ARPE PhD thesis prize from the French EPR Association. I'm more than happy to donate the prize to the @Programme_PAUSE in order to support Ukrainian researchers through @cdf1530 initiative "Solidarité Ukraine" #ScienceForUkraine
Image from Enrico Falcone (@EnriFalc1)
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