@BiophysicsGuy

Assistant Prof of Biochem & Mol Pharm, Baylor College of Medicine. CryoEM, Computational Biophysics, Drug Discovery. Stanford/Yale/Michigan Alum.

Joined November 2014
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Excited to share our work is out in @Nature! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. nature.com/articles/s41586-0…
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NatureStructMolBiol@NatureSMBApr 30
New online! Determinants of drug efficacy and the dynamics of G protein activation dlvr.it/TSJNJX
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Ben Myers Lab@Myers_labApr 30
Now online in @NatureSMB - We combine AlphaFold, structural, and biochemical approaches to show that SMO directly inhibits PKA via a pseudosubstrate mechanism—revealing a new mode of #GPCR signal transduction in the #Hedgehog pathway. Big thanks to everyone who contributed!
NatureStructMolBiol@NatureSMBApr 30
New online! Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway dlvr.it/TSJMr4
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nature
@NatureMar 16
Nature research paper: Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity go.nature.com/4rtdvbd

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity

Nature - Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes...

nature.com
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Replying to @BiophysicsGuy @Nature
Also check out great complimentary work by @emeKato! nature.com/articles/s41586-0…

The dynamic basis of G-protein recognition and activation by a GPCR

Nature - Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key...

nature.com
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New preprint from the Robertson Lab! We used AF ensemble generation for rigidity filtering with generative design to make cryoEM fiducials, enabling rapid inactive states of four drug targets and a beta2 extracellular fiducial to study GPCR activation! biorxiv.org/content/10.64898…
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Excited to share our study resolving the GTP-induced activation of the mu-opioid receptor-Gi complex with different agonists using cryoEM and MD simulations is live now @Nature, with additional MD sims, fluorescence work, and more! nature.com/articles/s41586-0…
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Happy to share that our paper on Metric Ion Classification (MIC) is now published! nature.com/articles/s41467-0…
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Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving Gi activation and how its modulated by different ligands! biorxiv.org/content/10.1101/…
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The Robertson lab has multiple openings for postdocs! Particularly interested in those with experience in either plate reader assays or ML, but all are welcome!; come learn about GPCRs, cryoEM, MD/FEP, drug discovery and more! jobs.bcm.edu/job/Postdoctora…
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Aashish Manglik@AashishManglik10 Oct 2024
We are recruiting a young researcher to join our dynamic lab at UCSF - this is a great opportunity if you would like to get some research experience before graduate or medical school! aprecruit.ucsf.edu/JPF05305. Please RT!
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Greg Bowman@drGregBowman28 Aug 2024
Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad @AndreaSoranno labs pnas.org/doi/10.1073/pnas.23…
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David B Sauer@DavidBSauer3 Jul 2024
And it's out! Structure and function of the proline transporter SIT1 in complex with ACE2 Congrats to Huanyu, Ashley, Irina, @robertvandenbe2, Liz Carpenter, @T_dafforn, and the many other collaborators from @CmdOxford, @uobbiosciences, @Sydney_Uni nature.com/articles/s41467-0…

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

Nature Communications - The SIT1-ACE2 complex transports the amino acid proline and is the receptor of SARS-CoV-2. Here, the authors identify specific sequence requirements for proline transport...

nature.com
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Das Lab@RDasLab26 Jun 2024
Calling the #moleculardynamics community – first CASP target ever for predicting water (ensembles) around a macromolecule: predictioncenter.org/casp16/… Will be evaluated by direct comparison to #cryoEM on the Tetrahymena ribozyme #RNA!
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"Mechanistic insights into G protein coupling with an agonist bound GPCR" Cool work led by the Hildebrand group. linkedin.com/posts/guillermo…

Hossein Batebi, Peter Hildebrand so happy 🎉 to see our work finally out in the open! What a long,...

Hossein Batebi, Peter Hildebrand so happy 🎉 to see our work finally out in the open! What a long, wonderful ride (with ups and downs 🎢 ) with beautiful results in the end. It’s been great working...

linkedin.com
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Meghna Gupta@MeghnaG2714 May 2024
1/6 Happy to share our new preprint- biorxiv.org/content/10.1101/… @lab_stroud, @GuptaLab_, Jeffrey Bennett, @Nikk_click, Andrew Nelson, Peter Hwang, Sergei Pourmal. Huge thanks to the funding agencies @NIHgrants @guthyjacksonfdn @UCSF (pbbr.ucsf.edu/) for their support.

Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica

Neuromyelitis Optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the human astrocyte water channel aquaporin-4 causing neurological impairment....

biorxiv.org
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Willow Coyote-Maestas@willowcoyote10 May 2024
Our paper is finally out in it's final form!
Molecular Cell@MolecularCell6 May 2024
Online Now: The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics dlvr.it/T6VdRZ
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Georg Hochberg@KaHochberg10 Apr 2024
Alright everybody, what will undoubtedly forever be the lab's strangest discovery is now out in Nature. It's a protein that evolved to self-assemble into a Sierpinski fractal. nature.com/articles/s41586-0… 1/n
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Ruth Huttenhain@rhuttenhain25 Mar 2024
So excited to see our work on "Profiling the proximal proteome of the activated μ-opioid receptor" using APEX-based proximity labeling and quantitative mass spec published today. It is the result of an amazing team effort! nature.com/articles/s41589-0… #TeamMassSpec #Proteomics #GPCR

Profiling the proximal proteome of the activated μ-opioid receptor

Nature Chemical Biology - A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking...

nature.com
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Very excited to share our new preprint where we develop MIC, a deep metric learning tool for classifying waters & ions in experimental structures; fantastic collaboration with the extremely talented Laura Shub and Selina Liu from the Keiser lab! biorxiv.org/content/10.1101/…
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