#Neuroimmunology lab @UCIrvine studying the role of #microglia in #Alzheimer’s disease and developing #iPSC-microglia based therapeutic approaches
Irvine, CA
Joined June 2018
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It was so much fun working with Sonia, Chris, and the Bennett lab team on this study. Looking forward to seeing all the ways we can apply this new approach to develop microglial-based therapeutics!
Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.
Blurton-Jones Lab retweeted
We are excited to share our newest publication from the @BlurtonJonesLab, "Harnessing human iPSC-moceoglia for CNS-wide delivery of disease modifying proteins."
sciencedirect.com/science/ar…
Blurton-Jones Lab retweeted
“Chimeric models of breast cancer brain metastases and demyelination” — such an interesting and innovative approach!
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins: Cell Stem Cell cell.com/cell-stem-cell/full…
Blurton-Jones Lab retweeted
“It is hard to put into words the extent of the damage being done to the US research enterprise, which is of almost incalculable value to both the nation itself and the wider world… An assault on science and scientists anywhere is an assault on science and scientists everywhere.”
nature.com/articles/d41586-0…
Blurton-Jones Lab retweeted
And as my grants are stripped away, I will say thank you so much for protecting me from antisemitism!
hhs.gov/about/news/2025/03/0…
Blurton-Jones Lab retweeted
More excellent work from the brilliant @LynnOlst. I’m a very proud PI today. More to come from @ARC_Neuro!
Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains.
A thread with our key findings is below! 🧵(1/15)
Blurton-Jones Lab retweeted
On this #RareDiseaseDay2025 , we cannot remain silent. We must fight on the beach, and on the bench. Call your elected officials, call those who weren't elected who have become our officials. It is not "saving" us money, it is costing us our future. #fightonthebench
Blurton-Jones Lab retweeted
@karchlab we are looking forward to your presentation at #TargetAD25 in Crete next May🇬🇷☀️Registration & Talk Submission is now OPEN so please RT to let your followers know!
Find out more: bit.ly/3zOJ0Y1
Blurton-Jones Lab retweeted
So excited to be part of the new VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD. Looking forward to working with our team @andcyang @JASchneiderMD @BlurtonJonesLab and Yadong Huang @GladstoneInst @rushalzheimers
Blurton-Jones Lab retweeted
We're excited for our latest work published in @Neuron! We explored the impact of Alzheimer's risk factors APOE4 and TREM2-R47H in a tauopathy mouse model, revealing elevated microglial cGAS-STING signaling and senescence in females with both risk factors. cell.com/neuron/fulltext/S08…
Blurton-Jones Lab retweeted
We hope this helps with clinical trial design for people with Down syndrome. Very much enjoyed this productive collaboration!
This research study examines #AlzheimersDisease drug on tissue samples from people with #DownSyndrome. Learn more about this research by co-corresponding author and #UCIMedSchool professor @ElzHead: bit.ly/4dS5sOG
Blurton-Jones Lab retweeted
Important paper on prevalance of CSF1R variants - congrats to David Lynch and colleagues
CSF1R-Related Disorder | Neurology Genetics neurology.org/doi/10.1212/NX…
Blurton-Jones Lab retweeted
APOE4-dependent neutrophil-microglia interactions drive cognitive impairment in female individuals with Alzheimer’s disease via IL17F @ButovskyLab, @OlegButovsky, @NetaRose11, @KilianKleemann #neutrophils, #microglia, #IL-17
nature.com/articles/s41591-0…
Blurton-Jones Lab retweeted
We are excited to share new paper led by the talented @NicoleScottHew1 that a microglial C1q, can be internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress cell.com/cell/fulltext/S0092…
Blurton-Jones Lab retweeted
Thanks, Matt! Very excited to continue our collaboration. I hope to see our work on Xe coming soon to light😜
Blurton-Jones Lab retweeted
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease @NatureMedicine
nature.com/articles/s41591-0…
Blurton-Jones Lab retweeted
CIRM proudly supported the 2nd Annual #ALSP Community Conference, which discussed cell-based therapies for leukodystrophies. Heidi Edwards of @SistersHopeALSP highlighted the importance of bridging gaps between patients, families, and professionals.
blog.cirm.ca.gov/2024/06/26/…
Blurton-Jones Lab retweeted
The @MontagneLab is very happy to have contributed to this @NeuroCellPress paper from the amazing Dr. David Munro in the Priller lab! #microglia #calcification
Nice to see this collaborative effort out!
Well done @AudreyChagnot & @Conasaurus1 👏
cell.com/neuron/fulltext/S08…
Blurton-Jones Lab retweeted
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy: Neuron cell.com/neuron/fulltext/S08…
Blurton-Jones Lab retweeted
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related neurodegenerative leukoencephalopathy: @NeuroCellPress cell.com/neuron/fulltext/S08…
Blurton-Jones Lab retweeted
-Lifelong absence of microglia causes neurodegenerative disease
-Transplantation of healthy microglia can rescue this neurodegenerative disease @NeuroCellPress cell.com/neuron/fulltext/S08…
