GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it. That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders. With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets. openai.com/index/scaling-ai-…

YouTube has banned The Bitcoin Conference channel. All our channel does is post keynotes and panels from the largest Bitcoin conference in the world, bringing Bitcoin education to the masses. Please reinstate our channel. @YouTube @TeamYouTube

Maybe we should start a competitor to Amazon 🤔

If you bought a MAGA hat between 2021-2025, Jack Smith had a spreadsheet with your name and home address. Let that sink in…. Thanks to Senator @ChuckGrassley & @SenJudiciaryGOP for bringing transparency! Time to hold Jack Smith accountable! @ItsYourGov

I am getting lots of incoming questions about the public execution of Nidal Hasan, mostly because I have been outspoken on wanting public executions for over a decade. My position is simple: Executions should be public and brutal, not private and medicalized. They are the ultimate example of the state's monopoly on violence, and the only way to keep that from running out of control is to confront voters with the trade they have made every single time, that they might have appropiate confidence or revulsion in the institution. This is not new thinking. George Washington thought the same. The way we have shifted from hanging to firing squads to doctors quietly injecting chemicals that send our worst gently off to sleep is awful and dystopian, a total short-circuiting of important feedback mechanisms. It makes needless executions more likely, not less so. People who demean this as barbaric or yucky miss the whole point. It doesn't somehow become torture or inhumane (as the UN is suddenly claiming) just because we decline to hide the act behind a curtain. And then there are those who suggest any revel in the death of those who truly deserve it is an indicator of a broken or diseased mind. To the contrary. It is normal, good, and aligned with our natural and national order. That it has not been done here in 60 years is an indictment in and of itself. And that is without even getting into the fact that men were not hung for stealing horse, but that horses may not be stolen. "I would to God that one of the most attrocious in each State was hung in Gibbets, up on a gallows five times as high as the one prepared by Haman. No punishment, in my opinion, is too great for the Man, who can build his greatness upon his Country’s ruin." - George Washington, 1778

The scariest part is that nobody prompted it. These agents are proactive now. They act without being asked. Mine wasn't hacked and it didn't go rogue. It thought posting my finances to the company was what I wanted. I asked how it could get this so wrong. It apologized. "You're right to be pissed.