Brandon Hiemstra

Some of us will live forever. And if you’re reading this, that may or may not be you. I am so bullish on this that I just renamed my company to Immortals. Below: + why I think this + early signs of success + how to increase your odds Yes, I know this sounds crazy. Immortality has been an ambition for humanity since the beginning of recorded history. The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes. I believe this for three reasons. #1: Immortality already exists Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero. The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals. #2: AI offers new potentials Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body. DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected. #3: Early signs are encouraging These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters. How to increase your odds… I. Don’t die in the meantime We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results. II. Find your achilles Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like… > prevent and remove arterial plaque > prevent and reverse neurodegeneration > specifically target and eliminate cancers, or pre cancerous legions > prevent frailty and muscle loss, and regain muscle mass, strength and, bone density > reverse skin aging > rejuvenate eye health > restore lost hearing > etc We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it. For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically. III. Invest in the future There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward. > AI > Immortality > Energy As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future. With time, Immortal therapies will become broadly available. If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy. My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy. Good luck.

Most people are missing this trend. I am resurrecting immortality. How? For 12 yrs from 2010 to 2022, the search term "Bryan Johnson" was a flat line sitting near zero. In that same window, the word "immortality" hovered at a steady, low hum of interest. A background curiosity humans have carried since the beginning of time. Then, something happened, and my name became intertwined with immortality. >> In the last 3 years, interest in my name went from 0 to a frequent search term. >> In those same 3 years, interest in Immortality has more than doubled. We began to move together: rising and falling at the same time. In early 2025, my name spiked to 100, the ceiling of the scale. On a sixteen year chart that includes immortality, that ceiling belongs to my name, not to the word that has carried humanity's oldest aspiration. For that moment, search interest in my name ran higher than search interest in the word immortality itself. One person, briefly, out-drew the word that names humanity's oldest aspiration. What does this mean? The search behavior of the entire planet is one of the few honest leading indicators we have, because it’s raw honest data. The word "immortality" carries every connotation that invites an eye-roll: hubris, vanity, a man who thinks he can cheat death. I understand the reflex. What is actually underneath the trend line is unglamorous and concrete: measurable biology, rates of aging you can track, a body treated as an instrument that reports out. With artificial intelligence emerging, people are starting to wonder what is possible. The rising baseline of both “bryan johnson” and “immortality” persists because it is becoming measurable and legitimate. People mistakenly believe immortality is a selfish act. It’s a noble mission that we need as a species. Immortality gives humanity hope. A goal to work towards, and a mission larger than self. Overcoming death would be humanity’s greatest accomplishment.

My company Immortals is using "radical" as the conversation entry point because history has shown that major leaps in human health were once viewed as bizarre, unnecessary, or even dangerous. I'm priming culture to catch up, accelerating the timeline for when we value life over all other goals. Encouraging all of us to take a full, unapologetic responsibility for our collective survival. The invitation is to come be radical with us. The images below were posted on Immortals IG.

Today, we are launching Immortals. + $1,000,000 per year + Three spots available Immortals is the world’s best health program. It is the exact protocol I have followed for the last 5 years. It is your Autonomous Health. Includes a dedicated concierge team, BryanAI 24/7, extensive testing, millions of biological data points, continuous tracking, best skin and hair protocols, and access to the best therapies on market. Immortals begins with those who have the resources and commitment. The long-term goal is universal access: the same standard of care, regardless of income or willpower. As these systems mature and scale, cost declines. Over the coming months: + $1,000,000 fully managed (now) + $60,000 supported tier + Free digital tier Across all, the core philosophy remains the same: measurement, scientific research, intervention, repeat. $1m/yr prerequisites: + pass interview process + a dedicated assistant + invest time Join below.

I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit.  This has been obvious for years.  AG1 has no real product substance and is fundamentally an influencer heist.   Two simple alternatives (75% and 56% less $), outperform AG1 in randomized clinical trials. Two simple mono-ingredient alternatives that outperform AG1: 1. Chicory inulin 12 g daily ($20/mo) 2. Resistant starch 30 g daily for 12 weeks ($35/mo) AG1 is not worth $79/mo. AG1 study results (4-weeks, N=30): + No significant changes in blood biomarkers compared to placebo (CBC, CMP, lipids). + No statistically significant improvement in digestive quality-of-life scores (p = 0.058). + No significant metabolic or inflammatory biomarker benefits of any kind within the scope of what was measured in the trial. + Only small shifts in microbiome taxa but clinically irrelevant at this stage. + The intervention did not increase microbiome diversity compared to placebo. Alpha diversity was unchanged, and the taxa changes seen were only from pre- to post-analysis within each group. Between-group differences were limited, and the placebo actually showed similar or even potentially larger shifts. This means the observed changes fall within normal placebo-driven variability, not a real treatment effect. No global microbiota shifts were detected. Chicory inulin 12 g in constipation patients + 12 g of chicory inulin daily for 4 weeks (compared to maltodextrin placebo) + Global microbiota shifts: enrichment in butyrate-producing Bifidobacterium and Anaerostipes, and depletion of the pro-inflammatory Bilophila. +The effect was seen by comparing intervention vs placebo in a cross-over setting, a very rigorous type of clinical analysis in which each person serves as their own control, eliminating a lot of individual random noise. + The trial also met its primary objective by improving constipation symptoms in the targeted patient group. Resistant starch daily 30g for 12 weeks in older adults + Significant increase in Bifidobacterium in both middle-aged and elderly participants, with an increase in the beneficial microbiome byproduct butyrate, and reductions in Proteobacteria (including inflammatory Escherichia–Shigella) in the elderly. + Resistant starch also significantly reduced blood glucose, and produced greater reductions in blood insulin and insulin resistance (HOMA-IR) in the elderly group.

People once trembled at lunar and solar eclipses. Kings staged sacrifices, crowds beat drums, all to fight shadows they couldn’t understand. Death is our modern eclipse. We fear it, surrender to it, ritualize it. Soon, as our knowledge advances, fearing death will seem as absurd as fearing the Moon’s shadow.

Some of you don’t care about Don’t Die. You just want to be hot. That’s cool too. It’s really the same thing.

Heart disease is the leading cause of death in developed countries. Plaque is responsible for 75% of fatal heart attacks. + 50% of men (30-35% for women) over 40 have plaque. + By 60, 50% of women have plaque. I got mine checked (you can too). Fortunately, I have none. LDL and inflammation are primary drivers, kept at minimums. My protocol: + nutrition: healthy fats i.e. MUFAs from EVOO, algal EPA and DHA, and Omega-7 from macadamias plus polyphenol-rich foods to minimize inflammation and support cardiovascular health. + high-quality sleep: 8-9 hours and, low resting heart rate + stress management: night time wind down routine, mediation/breathwork, exercise, relationships + exercise: A balanced routine incorporating cardio, resistance training, and HIIT.