@BraultMuscleLab

Associate Professor in the Center for Musculoskeletal Health at the Indiana U School of Medicine. Skeletal muscle energetics and the control of muscle mass.

 Indianapolis, IN
Joined November 2021
  • Tweets29
  • Following304
  • Followers410
6Media
Mitochondria are increasingly recognized as actionable targets in disease. These BEC papers look at different approaches, from targeting signaling pathways and mitochondrial metabolites to developing compounds for mitochondrial disease and cancer. #DrugTargeting Links👇
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The Hornberger Lab@HornbergerLabJan 21
📢Tenure Track Faculty Position: UW-Madison is expanding its research portfolio in aging and is interested in applicants who study the interplay between aging and skeletal muscle biology. 10 days left to apply - please RT and DM if you have questions. jobs.wisc.edu/jobs/immunolog…
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Marcas Bamman, PhD@MarcasBamman11 Feb 2025
Join us!
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Kelsey Fisher-Wellman, PhD@KFW_Lab5 Jun 2023
Excited to announce our group's latest preprint led by @IlyaNBoykov + @Mcmontgomery11 biorxiv.org/content/10.1101/… In it we compared OXPHOS expression/function, across various murine tumor types, matched normal tissues and other organs -- all normalized to mito content. 🧵below

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across tumor types

Targeting mitochondrial oxidative phosphorylation (OXPHOS) to combat cancer is increasingly being investigated using a variety of small molecule inhibitors. Clinical success for these inhibitors has...

biorxiv.org
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Shenhav Shemer Lab@Shenhav_Lab18 Apr 2023
It is with great sadness that we mourn the passing of Prof. Alfred Goldberg, my postdoc mentor and colleague. Fred’s contributions to science were profound and far-reaching, and his passing leaves a void. He was a passionate advocate for science and education. We will miss him.
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Everett Minchew@everettminchew22 Mar 2023
No oxygen? No problem 💪 Thrilled to reveal evidence of a mammalian skeletal muscle that functions properly without O₂. A massive effort by the team! @EspenLab @APS_Function @MYOTWlTTER #myotwitter academic.oup.com/function/ad…

Function

journals.physiology.org
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#ArticlesInPress “Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1” By: Paul S. Hafen, et al. ow.ly/19VJ50KLsc6 #JAPPL #Fatigue #SexDifferences
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Kelsey Fisher-Wellman, PhD@KFW_Lab6 Sep 2022
📢#Mitochondria and #Cancer drug resistance📢 How much energy does it cost to run drug efflux pumps? This and more are what we set out to answer in our latest work, just published in BBA – Bioenergetics. sciencedirect.com/science/ar… 🧵below 1/
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Jake Hines@jhhines28 Jul 2022
We've developed smartphone fluorescence microscopes, aka Glowscopes. A few simple and inexpensive components convert your smartphone into a basic fluorescence microscope. 1/n
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Kelsey Fisher-Wellman, PhD@KFW_Lab19 Jun 2022
PSA: Static ATP levels do not reflect ATP turnover, ATP charge or mitochondrial OXPHOS. In this case, inhibition of mito flux increased ATP/ADP, consistent with mito ATP consumption, not synthesis...
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It's often said that ATP is the 'Energy Currency' of the cell.. But how exactly does that work? How do we quantitate the relationship between metabolic network fluxes and the energy that is dissipated to drive all the things that cells do? Check out this🧵1/3
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David A Hood@dhood_york3 Mar 2022
The early bird deadline for registration and abstract submission for IBEC 2022 is coming up later this month (March 25). Looking forward to seeing you all in Toronto. To register and submit an abstract, please visit event-wizard.com/IBEC22/0/we…
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Gilles Gouspillou@GGouspillou8 Dec 2021
To all Seahorse XF Analyzer users: If basal oxygen consumption rate (OCR) > FCCP-induced OCR: your experiment failed. If basal OCR = FCCP-induced OCR: your experiment might have (likely) failed. The use of uncouplers (like FCCP) to achieve max OCR requires proper titration.
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