@Brunorm84

Group Leader of the Obesity, Diabetes and Metabolism Lab at the Biomedical Research Institute of Murcia (IMIB) | PI & Research Professor (Tenured)

 Murcia, Spain
metaobesitylab.com
Joined March 2009
  • Tweets14.9K
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🔎 We are looking for outstanding postdoctoral researchers interested in applying for the upcoming Juan de la Cierva (@AgEInves) and Sara Borrell (@SaludISCIII) fellowship calls to join the Obesity, Diabetes and Metabolism lab at @IMIB_RMurcia (Murcia,🇪🇸) under my supervision👇
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Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in #obesity @ScienceAdvances science.org/doi/10.1126/scia…

Furan fatty acids reprogram hepatic lipid metabolism via acyl-CoA conjugates in obesity

Dietary fish oil (FO) and omega-3 fatty acids are associated with cardiometabolic benefits, yet their molecular mediators remain incompletely defined. Furan fatty acids (FuFAs), a distinct lipid...

science.org
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Disrupting the PNPLA3-ABHD5 Interaction Stimulates Lipolysis and Improves PNPLA3-I148M–Associated Hepatic Steatosis #MASLD @Diabetes_ADA diabetesjournals.org/diabete…

Disrupting the PNPLA3-ABHD5 Interaction Stimulates Lipolysis and Improves PNPLA3-I148M–Associated...

People with an I148M mutation in the PNPLA3 protein are at high risk of developing hepatic steatosis and progressive liver disease. The PNPLA3-I148M mutant

diabetesjournals.org
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Hyperactive mTORC1 underlies sex dimorphic progression of #MASLD in mice with hepatocyte prohibitin-1 deficiency @MolMetab sciencedirect.com/science/ar…
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Bruno Ramos-Molina, PhD retweeted
Eleonora Scorletti MD, PhD@EScorlettiOct 22
The Scorletti Lab website at @HopkinsMedicine @HopkinsGIHep is now live: scorlettilab.com We are recruiting Postdoctoral Fellows to study cellular mechanisms underlying metabolic disease, aging, and cancer using iPSC-derived hepatocytes and organoids.
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A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice #microbiota #CVD @Nature nature.com/articles/s41586-0…

A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice

Nature - The administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

nature.com
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Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice #aging #obesity @NatureComms nature.com/articles/s41467-0…
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Metabolic benefits of ketohexokinase inhibition in individuals with #MASLD: a randomized placebo-controlled crossover trial @NatMetabolism nature.com/articles/s42255-0…

Metabolic benefits of ketohexokinase inhibition in individuals with MASLD: a randomized placebo-c...

Nature Metabolism - In a randomized placebo-controlled crossover trial, pharmacological inhibition of ketohexokinase improved hepatic and systemic metabolic health in individuals with MASLD,...

nature.com
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Bruno Ramos-Molina, PhD retweeted
Manuel D. Gahete@ManuelDGaheteOct 7
🔬 Postdoctoral opportunity | Juan de la Cierva 2026 The @MolHepatolGC30 is looking for a talented postdoctoral researcher to join our team. 🧬 MASLD/MASH & HCC 🧬 RNA biology & tRNA/ARSs 🧬 Splicing & RNA metabolism 📩 Interested? Send your CV + short research statement
🤖 Made with AI
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Microbiota-host genetic interactions modulate #MASLD risk in PNPLA3I148M carriers via ceramides and are reversible by targeted microbial interventions @Gut_BMJ gut.bmj.com/content/early/20…
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Senolytics dasatinib and quercetin in #MASH: a proof-of-principle randomized, controlled trial @NatMetabolism nature.com/articles/s42255-0…

Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-o...

Nature Metabolism - In a double-blind, placebo-controlled trial, intermittent dasatinib and quercetin treatment over 21 weeks improves liver fibrosis in patients with MASH, as shown by paired liver...

nature.com
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Cell Metabolism@Cell_MetabolismOct 2
New! Online now: Fungus Rhizopus arrhizus promotes MASLD-associated hepatocellular carcinoma through generating kynurenic acid dlvr.​it/TVlT0b
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Nature Metabolism
@NatMetabolismOct 2
Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction dlvr.​it/TVl8W9
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SEBBM
@SEBBM_esOct 2
📅 Save the date! El 49º Congreso Internacional de la SEBBM será en Murcia del 7 al 10 de septiembre de 2027 🍋🧬 Reserva ya estas fechas en tu agenda. ¡Muy pronto más información! #49congresoSEBBM
Banner del 49º Congreso Internacional SEBBM, Murcia, 7-10 septiembre 2027: una espiral de piel de limón con una doble hélice de ADN y la torre de la catedral de Murcia

ALT Banner del 49º Congreso Internacional SEBBM, Murcia, 7-10 septiembre 2027: una espiral de piel de limón con una doble hélice de ADN y la torre de la catedral de Murcia

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nature
@NatureSep 30
Nature research paper: Hepatocytes promote liver metastasis of pancreatic cancer by providing serine go.nature.com/4hwk1v4

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

Nature - Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting...

nature.com
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Microbial aldehyde-alcohol dehydrogenase degrades #metformin to limit therapeutic response in type 2 #diabetes @Cell_Metabolism cell.com/cell-metabolism/ful…
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New paper out from the lab! “An explainable ML model using baseline gut #microbiota, circulating SCFAs, and clinical features to predict #weightloss response after #RYGB" @IJSurgery Congrats to all the authors for their outstanding contribution! @IMIB_RMurcia @FFIS_CARM @UCAM
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ovid.com/jnls/international-…

An explainable machine-learning model using... : International Journal of Surgery

Background:Roux-en-Y gastric bypass (RYGB) is one of the most effective treatments for severe obesity; however, postoperative weight-loss response...

ovid.com
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Targeting lipidated amino acid deficiency mitigates fibrosis via a PPARα/CCL2 axis in #MASH models @jclinicalinvest jci.org/articles/view/204511
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Glutamine metabolism as a rheostat of CD4+ T cell pathogenic function in #MASLD @Cell_Metabolism cell.com/cell-metabolism/ful…

Glutamine metabolism as a rheostat of CD4+ T cell pathogenic function in metabolic dysfunction-as...

Sawada et al. show that reduced hepatic glutamine drives pathogenic CD4+ T cell responses that promote MASLD progression. Restoring liver glutamine suppresses inflammation and limits liver injury....

cell.com
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Hepatic Usp2 orchestrates de novo lipogenesis through G3bp2 stabilization and β-catenin activation #MASLD @cddpress nature.com/articles/s41420-0…
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