Our lab adopts a structural biology approach to investigating the role of membrane proteins in host-pathogen interactions.

Imperial College London, UK
Joined October 2015
Exciting cryoET structure of the COPII coat from the Zanetti lab. rdcu.be/dZuzf
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James Hutton Institute@JamesHuttonInst5 Nov 2024
Congratulations to Prof Paul Birch, based @JamesHuttonInst and Head of the Division of Plant Sciences @dundeeuni, who was recently awarded the @BS_PP RKS Wood Prize 🏆 The prize celebrates excellent #science in the study of #plantdisease biology. More: bit.ly/48DuShV
Exciting news! 🎉 BSPP's 2025 RKS Wood Prize has been awarded to Professor Paul Birch for his outstanding contributions to plant pathology. 🌿🔬 Learn more about his incredible achievements and this prestigious award here:📷buff.ly/4h95btp
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📢Are you interested in cryo-EM, AI and Machine Learning? Then please check out the open #PhDposition in @Specklab and Yuriy Chaban’s group - Developing AI Approaches to Uncover Regulatory Protein Dynamics in DNA Replication at the MRC LMS on FindAPhD.com
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Final version of our manuscript reporting how a plant pathogen hacks host membrane trafficking is out. Great team work with @dromius @BubeckLab and @KamounLab science.org/doi/10.1126/scia… 😊👇
Mind the GAP-New research alert!🚨Our latest study revealed the first known case of a pathogen effector targeting a RabGAP! 🦠The effector remodels the pathogen interface and suppresses defense-related secretion mediated by its cognate Rab.🌱🚦 #research biorxiv.org/content/10.1101/…
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Our new preprint, in collaboration with @KamounLab and contributions from @jonathandgjones, @AdamWu9527, and @JiorgosKourelis labs, on the exciting discovery of organelle targeting by an activated helper NLR is out! 👇
🚨 A new twist in #NLRbiology! 🚨 Excited to report on the surprising mechanism where the helper NLR NRG1 targets organellar membranes to trigger immunity unlike canonical CC-NLRs, which function at the plasma membrane! 1/11 🧵 doi.org/10.1101/2024.09.19.6…
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I have an exciting postdoctoral position @imperialeee on machine learning for Computational Light-field Microscopy. More details here: jobs.ac.uk/job/DJV050/resear…
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Meeting alert - Biological Structures Group Winter meeting 2024 will be hosted by @Carter_Lab at the MRC LMB on December 6th! We have a fantastic line up of speakers and opportunities for poster presentations. @BiochemOxford @KavliOxford
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Postdoctoral position UK #postdoc #postdoctoral #AcademicTwitter
We're recruiting! Looking for a postdoc in a fun and inclusive lab doing cutting edge #CryoEM in a great city? Come join us @imperialcollege and be part of an interdisciplinary team funded by @wellcometrust @ImperialLifeSci imperial.ac.uk/jobs/search-j…
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Next, @TarhanEI will discuss 'AI-guided structural approaches in deciphering viral modulation of plant autophagy' 🪴
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New paper from our team using smFRET MS and cryoEM to see SurA delivering OMPs to BAM. Well done all - proud to work with you all! rdcu.be/dSDfs.
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I am deeply honored and humbled to have been elected as a member of @EMBO. This recognition would not have been possible without the incredible contributions of my past and current research group members. Thank you for your hard work and dedication! helsinki.fi/en/hilife-helsin…
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🎉 NEWS: TSL group leader, Wenbo Ma @wenboEffector, elected as @EMBO member for her significant contributions to molecular plant pathology. ➡️ tsl.ac.uk/news/wenbo-ma-awar… 🏆 This remarkable achievement underscores Wenbo's commitment to advancing plant pathology research.
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NEW Seminar: "Molecular mechanisms of herpesvirus assembly" hosted by @BubeckLab (@ImperialLifeSci) with @AtomicVirology (@Cambridge_Uni) 🗓️: 10/07/2024 🕐: 13.00 🌍: Flowers G47A
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bioRxiv: A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity (2024) sco.lt/6SNW4m
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Bubeck Lab retweeted
Replying to @CNIOStopCancer
@CNIOStopCancer is recruiting 2 new Junior group leaders Interested in developing your research line in AI applied to structural biology, protein design, drug discovery, Big Data, etc.? This is a great opportunity to start your lab! DM for more info cnio.es/empleo/junior-groups…
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Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗 Apply using the link below 👇 and help us spread the word! cnio.es/en/empleo/junior-gro…
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A "tour de force" by all our speakers in the #structural_insights and #mechanisms Day 1 session of the @AegeanConf #ComplementTherapeutics meeting! Kudos to @BubeckLab @arshukla @gregers_rom @ThomSharp & Mihaly Jozsi for putting together such engaging presentations!
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