Lukasz Bugaj retweeted
Postdoctoral position available!
We're looking for a creative scientist interested in signaling-mediated control of cell cycle transitions.
If you're excited by single molecule imaging, live cell biosensors, and fundamental molecular mechanisms, we'd love to hear from you.
Lukasz Bugaj retweeted
BE Seminar Series this Thurs w @BugajLab, @pennbioeng “Using Light, Temperature, and Protein Condensation to Understand and Control Cells”
be.mit.edu/our-community/sem…
Lukasz Bugaj retweeted
I wrote an Op-Ed about the government's attacks on Harvard. Please share with anybody who thinks these attacks help anybody.
prosyn.org/PhWi74r?h=KyJ1iCf…
Lukasz Bugaj retweeted
Check out our paper, now extensively revised and published in @MolecularCell! This has been a real tour de force led by @stephsansbury and @YSereb and we are very excited about the findings and future potential of this approach
cell.com/molecular-cell/abst…
Lukasz Bugaj retweeted
Geometric packing of tubules in the developing kidney urinary collecting system leads to tissue stiffening and rhythmic mechanical stresses local to nephron-forming niches that synchronize with tubule branching. @HughesLabPenn
nature.com/articles/s41563-0…
Lukasz Bugaj retweeted
Tomorrow 10/25 at 4pm: Lukasz Bugaj, PhD, @BugajLab @Penn presents "Perturb to understand: optical and thermal control of condensation, signaling, and cell behavior" at our @ucsf Friday Seminar Series in Basic and Translational Research. ow.ly/65Me50TSQCG
Lukasz Bugaj retweeted
Looking forward to hosting the next generation of exceptional scholars today!! Come join us in John Morgan Auditorium for amazing talks and networking after. @PennMedicine @BMBGGUPENN
Lukasz Bugaj retweeted
So delighted that @NikonSmallWorld selected our replica of Vermeer’s “Girl with a Pearl Earring,” made out of cells, as an Honorable Mention!
nikonsmallworld.com/gallerie…
@AriaHzy @RiverDreamsFilm @HughesLabPenn @pennbioeng
Lukasz Bugaj retweeted
Very honored to deliver an invited talk at the 4th Optogenetic Technologies and Applications Conference at the beautiful Wightman Mansion in Boston (image below). My presentation was titled “Wireless, Battery-Free Optoelectronic Systems for Optogenetic Studies With Small Animal Models”. I presented an overview of the history of our work in this area, up to and including some very recent results that combine implantable devices for physiological/behavioral monitoring with those for optogenetic neural control in mice (Neuron, 2024 @NeuroCellPress; see below), and some unpublished work on implantable ‘optogenetic displays’. One general feature of our approach in these and other related sub-fields of neuroengineering research is to consider device designs that can be adapted for scaled production. Our aim here is not to stop with ‘hero’ publications on advanced device technologies, but to follow through to provide broad access to any interested neuroscience investigator. The vehicle for this purpose is an engineering-oriented small company (Neurolux, Inc @NeuroLuxInc) that we launched ten years ago to respond to in-bound requests for devices -- no VCs, no investors, no pitch decks, no exit strategies, etc, just engineering excellence and a robust, sustainable business model. Thanks to the conference chairs, Prof. Lukasz Bugaj @BugajLab, Prof. Emmanuel Tzanakakis and Prof. Megan McClean @McCleanLab for the invitation to participate!
cell.com/neuron/fulltext/S08…
Lukasz Bugaj retweeted
Princeton's new Omenn-Darling Bioengineering Institute (@omenndarlingbio) is running multiple faculty searches this year! We are really excited to grow our bioengineering faculty & move into a brand-new building. Postdocs on the market - apply at: puwebp.princeton.edu/AcadHir…
Lukasz Bugaj retweeted
Excited to launch our cloud-based image analysis platform today at nimbusimage.org! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.
Lukasz Bugaj retweeted
Our latest: a new optogenetic system for precise spatiotemporal control of gene expression
We use it to dissect the dynamics of Shh gradient formation & patterning
A thread 🧵
biorxiv.org/content/10.1101/…
Lukasz Bugaj retweeted
Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields.
This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate.
Can you tell where the magnet is?
Want some? It's on Addgene now! addgene.org/219957/
Lukasz Bugaj retweeted
Dysregulated MYC contributes to half of all human cancers: but how? Our work shows that enhanced MYC forms condensates via phase separation that selectively modulates the transcriptome and promotes proliferation. Done by our chemogenetic tool SPARK-ON. nature.com/articles/s41594-0…
Lukasz Bugaj retweeted
Happy to share that work led by grad students Zack Harmer and Jaron Thompson, with significant contributions from David Cole, is now out in the journal @ACSSynBio. This work developed out of a productive collaboration with the research groups of Zavala and Venturelli.
Lukasz Bugaj retweeted
Penn's 2021 @iGEM team, which won multiple awards under the mentorship of @BugajLab and several #PennBioengineering graduate students, has published optoPlateReader, their open-source optogenetic device.
@WillBenman @David_GonzMar @PennEngineers
Read more: bit.ly/3Qxqppd
Lukasz Bugaj retweeted
Paper! Imagine walking on the floor with your hands…We made this for living tissues using E-cadherin (cell handshake protein). Cells treat the floor as a giant cell and ‘get weird’—>new biomedical material! Hurray KevinSuh*/ElenaCho*,@ibreinyn. doi.org/10.1016/j.celrep.202…! 🧵
Lukasz Bugaj retweeted
Replying to @dallandrummond @biorxivpreprint
Conservation of adaptive biomolecular condensation now published!
nature.com/articles/s41467-0…
Lukasz Bugaj retweeted
Step aside muscle, our new work shows that kidney and intestine tissue can also change shape and function when electrically stimulated (movie)! We call this ‘electroinflation’! Long overdue hurrah for @GawoonS* /IsaacBreinyn*, @almcalvo, Sameeksha. nature.com/articles/s41467-0…
Lukasz Bugaj retweeted
In the middle of the move to the new @FMIscience building I am so happy to share this work with @ViventisMicro @FranziskaMoos @SimonSuppinger @gusqgmed. Imaging organoids (and hydra 😀 ) has never been so easy and beautiful!!
A highly versatile open-top, dual view and dual illumination light sheet microscope developed by @priscaliberali and colleagues enables live imaging of large specimens.
nature.com/articles/s41592-0…






























