𝗪𝗮𝗻𝘁 𝗲𝗮𝗿𝗹𝘆 𝗮𝗰𝗰𝗲𝘀𝘀 𝘁𝗼 𝗿𝘂𝗻 𝗧𝗖𝗥- 𝗼𝗿 𝗕𝗖𝗥-𝗦𝗲𝗾 𝗼𝗻 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀? 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮'𝘀 𝗗𝗿𝗶𝘃𝗲𝗿𝗠𝗮𝗽 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗻𝘂𝗰𝗹𝗲𝗶𝗰 𝗮𝗰𝗶𝗱 (𝗰𝗳𝗗𝗡𝗔 +𝗰𝗳𝗥𝗡𝗔) 𝗮𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗽𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴 (𝗰𝗳𝗔𝗜𝗥) 𝗮𝘀𝘀𝗮𝘆 extends immune repertoire profiling beyond traditional tissue and PBMC samples by analyzing cell-free DNA (cfDNA), cell-free RNA (cfRNA), and extracellular vesicles (EVs) from plasma. Key advantages of this assay include: ✔ Optimized for fragmented nucleic acids ✔ Single-tube multiplex workflow ✔ Comprehensive profiling of all TCR and BCR receptor chains ✔ Sensitive detection from as few as 10 template molecules Learn more by viewing the poster: cdn.shopify.com/s/files/1/00… 𝗗𝗼 𝘆𝗼𝘂 𝗵𝗮𝘃𝗲 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀? Want 𝗲𝗮𝗿𝗹𝘆 𝗮𝗰𝗰𝗲𝘀𝘀 to this technology? 𝗘𝗺𝗮𝗶𝗹 𝘂𝘀 𝘁𝗼𝗱𝗮𝘆 𝗮𝘁 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗲@𝗰𝗲𝗹𝗹𝗲𝗰𝘁𝗮.𝗰𝗼𝗺 #DriverMapAIR #LiquidBiopsy #ImmuneProfiling #TCRSeq #BCRSeq #FunctionalGenomics #Cellecta

Published Research Spotlight 🧬🔬 A recent 𝘊𝘢𝘯𝘤𝘦𝘳 𝘙𝘦𝘴𝘦𝘢𝘳𝘤𝘩 study used 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮’𝘀 𝗖𝗹𝗼𝗻𝗲𝗧𝗿𝗮𝗰𝗸𝗲𝗿™ 𝗫𝗣 𝗟𝗲𝗻𝘁𝗶𝘃𝗶𝗿𝗮𝗹 𝗘𝘅𝗽𝗿𝗲𝘀𝘀𝗲𝗱 𝗕𝗮𝗿𝗰𝗼𝗱𝗲 𝗟𝗶𝗯𝗿𝗮𝗿𝘆 to follow clonal dynamics in a pancreatic ductal adenocarcinoma (PDAC) model in vivo. Researchers barcoded KPC tumor cells, introduced either control or Dpy30-targeting sgRNAs, transplanted the cells into immunodeficient and immunocompetent mice, and then analyzed barcode representation by NGS. The results revealed a striking depletion of Dpy30-KO barcoded clones in immunocompetent mice, accompanied by increased tumor-infiltrating lymphocytes. Additional experiments supported a key role for CD8+ T cells in clearing DPY30-deficient tumor cells. More broadly, the study found that loss of DPY30 destabilized stressed replication forks, promoted genomic instability and inflammation, and increased sensitivity to immune checkpoint blockade. In the preclinical anti–PD-1 experiments, 60% of mice bearing Dpy30-KO tumors showed complete tumor regression. 𝗧𝗵𝗶𝘀 𝘄𝗼𝗿𝗸 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗵𝗼𝘄 𝗰𝗲𝗹𝗹 𝗯𝗮𝗿𝗰𝗼𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝗰𝗹𝗼𝗻𝗮𝗹 𝘁𝗿𝗮𝗰𝗸𝗶𝗻𝗴 𝗰𝗮𝗻 𝗵𝗲𝗹𝗽 𝗿𝗲𝘃𝗲𝗮𝗹 𝗰𝗼𝗻𝘁𝗲𝘅𝘁-𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘁𝘂𝗺𝗼𝗿 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗵𝗮𝘁 𝗺𝗶𝗴𝗵𝘁 𝗼𝘁𝗵𝗲𝗿𝘄𝗶𝘀𝗲 𝗯𝗲 𝗱𝗶𝗳𝗳𝗶𝗰𝘂𝗹𝘁 𝘁𝗼 𝘂𝗻𝗰𝗼𝘃𝗲𝗿. Read the Full Publication Here 👉 aacrjournals.org/cancerres/a… Or learn more about how clonal barcoding can help accelerate your discovery. cellecta.com/collections/clo… #CloneTracker #ClonalTracking #CellBarcoding #CancerResearch #PancreaticCancer #PDAC #Immunotherapy #FunctionalGenomics #NGS #Cellecta

Using a modified DriverMap™ AIR workflow, 𝗖𝗲𝗹𝗹𝗲𝗰𝘁𝗮 𝗽𝗿𝗼𝗳𝗶𝗹𝗲𝗱 𝗰𝗲𝗹𝗹-𝗳𝗿𝗲𝗲 𝗗𝗡𝗔 & 𝗥𝗡𝗔 𝗮𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗶𝗺𝗺𝘂𝗻𝗲 𝗿𝗲𝗽𝗲𝗿𝘁𝗼𝗶𝗿𝗲𝘀 (𝗗𝗿𝗶𝘃𝗲𝗿𝗠𝗮𝗽 𝗰𝗳𝗔𝗜𝗥) 𝗳𝗿𝗼𝗺 𝗽𝗹𝗮𝘀𝗺𝗮 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 collected from healthy donors and patients with NSCLC, melanoma, and hepatocellular carcinoma. Study highlights: ✔ Thousands of clonotypes detected in matched plasma-FFPE tissue samples ✔ cfRNA demonstrated greater sensitivity in detecting clonotypes than cfDNA alone ✔ Both T-cell and B-cell receptor clonotypes were detected across multiple sample types Read the full poster: cdn.shopify.com/s/files/1/00… Do you have plasma samples? Are you interested in TCR- or BCR- repertoire profiling? Reach out at [email protected] #DriverMapAIR #CancerResearch #LiquidBiopsy #ImmuneProfiling #TCRSeq #BCRSeq #Cellecta

Unlock deeper insights with functional genetic screening. 🧬 Using CRISPR or RNAi libraries combined with bioinformatics analysis, Cellecta can help researchers uncover the genetic drivers behind complex biological responses, including: • Identifying mechanisms of action and synergistic drug targets • Understanding complex phenotypes such as differentiation, senescence, infection, oncogenesis, and metastasis • Mapping genetic mechanisms involved in drug resistance • Discovering new pathways and potential therapeutic targets Ready to explore what functional screening could reveal in your research? Contact Cellecta to discuss your specific CRISPR or RNAi screening needs. 🔗 cellecta.com/products/crispr… #CRISPR #RNAi #GeneticScreening #FunctionalGenomics #DrugDiscovery #Bioinformatics #Genomics #LifeSciences #Biotech #Research

Streamline your CRISPR workflow with Cellecta’s Cas9-Expressing Cell Line Service. From selecting your Cas9 variant to delivering fully validated cells with Cas9 activity data—we handle every step for you. For faster results, you may want to check out our off-the-shelf, ready-to-use, f𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹𝗹𝘆 𝘃𝗮𝗹𝗶𝗱𝗮𝘁𝗲𝗱 Cas9-expressing cell lines: cellecta.com/pages/cas9-and-… Proven results: Reliable Cas9 copy number and knockout efficiency give your experiments the strongest foundation. Get started today: cellecta.net/cas9-cell-line-… #Cas9 #CRISPRTools #CellEngineering #FunctionalGenomics #Cellecta

Track cells. Follow clones. Uncover what changes. Cellecta’s CloneTracker™ XP Barcode Libraries and Kits let researchers label large cell populations with stable, heritable, sequenceable barcodes, helping them follow individual clones and their descendants through treatment, differentiation, disease progression, and other experimental conditions. CloneTracker™ can help researchers: • Assess changes in cell population heterogeneity • Identify clones that survive drug treatment or other selection pressures • Track cell diversity during differentiation or disease progression • Quantify barcoded populations using genomic DNA sequencing, with select CloneTracker XP™ configurations also compatible with RNA-Seq analysis Give every clone an identity and see where the science takes it. Learn more about CloneTracker™ Barcode Libraries and Kits: cellecta.com/collections/clo… #CloneTracker #CellBarcoding #ClonalTracking #Genomics #CellBiology #DrugResistance #CancerResearch #RNASeq #LifeSciences #Cellecta

Cellecta's DriverMap™ AIR TCR–Antigen Discovery Workflow brings together the tools needed to identify, reconstruct, and validate antigen-specific T-cell receptors in one streamlined process. Our workflow supports: ✔ Bulk TCR repertoire sequencing ✔ Single-cell α/β chain-pair recovery ✔ Functional testing with Jurkat TCR reporter cells ✔ Antigen validation using K562 APC co-culture By connecting each stage of TCR discovery, researchers can move more efficiently from sequencing data to validated biological insights. 🔗 Learn more: cellecta.net/tcr-antigen-dis… #Immunotherapy #TCR #DriverMapAIR #SingleCellSequencing #CancerResearch #FunctionalGenomics #Cellecta

Every experiment is different—which is why Cellecta offers Custom Lentiviral Barcode Libraries tailored to your specific research goals. Whether you're studying lineage relationships, clonal evolution, or cell population dynamics, our custom libraries provide: ✔ Millions of unique barcode sequences ✔ Stable, heritable genomic integration ✔ DNA- and RNA-based barcode detection ✔ Flexible vector, marker, and selection options If our standard libraries don't meet your needs, we'll work with you to create a custom solution. 🎉 Limited-time offer: Buy one qualifying library and receive 30% off one screening support product with code BLG30. Learn more: cellecta.com/pages/current-p… #BarcodeLibraries #CloneTracking #FunctionalGenomics #CRISPR #LentiviralLibraries #Cellecta

Every experiment is different—which is why Cellecta offers Custom Lentiviral Barcode Libraries tailored to your specific research goals. Whether you're studying lineage relationships, clonal evolution, or cell population dynamics, our custom libraries provide: ✔ Millions of unique barcode sequences ✔ Stable, heritable genomic integration ✔ DNA- and RNA-based barcode detection ✔ Flexible vector, marker, and selection options If our standard libraries don't meet your needs, we'll work with you to create a custom solution. 🎉 Limited-time offer: Buy one qualifying library and receive 30% off one screening support product with code BLG30. Learn more: cellecta.com/pages/current-p… #BarcodeLibraries #CloneTracking #FunctionalGenomics #CRISPR #LentiviralLibraries #Cellecta

Using a modified DriverMap™ AIR workflow, Cellecta profiled immune repertoires from plasma samples collected from healthy donors and patients with NSCLC, melanoma, and hepatocellular carcinoma. Study highlights: ✔ Thousands of clonotypes detected in matched FFPE tissue samples ✔ cfRNA demonstrated greater sensitivity than cfDNA alone ✔ Detection of both T-cell and B-cell receptor clonotypes across multiple sample types Read the full poster: cdn.shopify.com/s/files/1/00… #DriverMapAIR #CancerResearch #LiquidBiopsy #ImmuneProfiling #TCRSeq #BCRSeq #Cellecta

Optimize your CRISPR and shRNA screens with Cellecta’s Functional Genetic Screening Analysis. Our bioinformatics pipeline integrates MAGeCK, DrugZ, and custom tools to: ✅ Identify essential genes ✅ Analyze gene-drug interactions ✅ Map key pathways From DNA isolation to sequencing and guide frequency reporting, we provide comprehensive, high-quality analysis to drive impactful discoveries. Explore our bioinformatics services: cellecta.com/collections/bio… #GeneticScreening #FunctionalGenomics #CRISPR #Bioinformatics #GeneEditing #Cellecta

If you're a first-time DriverMap™ user, now is the perfect time to get started. For a limited time, receive 50% off your first DriverMap AIR or DriverMap EXP assay kit. 📩 Contact [email protected] to request a quote and learn more! cellecta.com/collections/dri… #DriverMap #RNASeq #TCRSeq #BCRSeq #GeneExpression #FunctionalGenomics #Cellecta

🇺🇸 Happy Fourth of July from all of us at Cellecta! Wishing our customers, partners, and the scientific community a safe and enjoyable holiday. Thank you for your continued dedication to advancing research and innovation. Have a wonderful Independence Day! #FourthOfJuly #IndependenceDay #Cellecta #Biotech #LifeScience #Research

Need precise gene knockouts, knock-ins, or custom tags in your cell line of choice? Cellecta’s Custom Cell Engineering Service delivers targeted, validated cell pools or clonal lines—designed to fit your experimental goals. ✔ Knockout, knockdown, or knock-in ✔ Zero-footprint CRISPR edits ✔ CRISPRa/CRISPRi for inducible expression ✔ Reporter and non-CRISPR options available Just pick your cell type and genetic modification—we’ll handle the rest. Learn more at: cellecta.net/cell-eng-natmet… #CustomCellLines #CRISPREngineering #GeneEditing #FunctionalGenomics #CellEngineering #BiotechSolutions #Cellecta

Cellecta’s Single-Cell CRISPR Screening Service (Perturb-Seq, CRISP-Seq, CROP-Seq) lets you study how genetic perturbations reshape mRNA expression at the single-cell level—using 10X Chromium scRNA-Seq. - Analyze 100+ gene perturbations in a single pooled experiment - Combine CRISPR KO, CRISPRi, or CRISPRa with single-cell profiling - Discover regulators and pathways missed in bulk screens Turn complex cellular responses into actionable insights. Get a quote at: cellecta.com/products/single… #SingleCellCRISPR #PerturbSeq #CRISPRScreening #FunctionalGenomics #scRNASeq #Cellecta #GeneEditing #10XGenomics

🚀 **Built for Better Genome-Wide Screens** The latest **87K Human CRISPR Knockout Library** from Cellecta combines advanced guide design with enhanced tracrRNA architecture to support high-confidence functional screening. Highlights: • Targets ~19,382 genes and 1,859 microRNAs • Includes extensive non-targeting and safe-harbor controls • HECG tracrRNA design improves on previous generations • Available in multiple vector formats and as packaged lentivirus Designed to generate stronger depletion signals and more robust screening results compared with previous-generation libraries. cellecta.com/collections/cri… #CRISPR #FunctionalGenomics #GenomeWideScreening #GeneEditing #Biotech #Cellecta

Cellecta is heading to EACR 2026, taking place June 8–11 at Hungexpo in Budapest. Visit us at Stand 98 to learn about our latest technologies for functional genomics, immune profiling, CRISPR screening, and cell engineering. 🎤 Industry Spotlight Presentation 🗓 Wednesday, June 10 ⏰ 11:10–11:25 AM Stop by our booth, attend our presentation, and connect with the team to discuss your research and upcoming projects. 🔗 Learn more and schedule a meeting: cellecta.com/blogs/events-co… #EACR2026 #CancerResearch #FunctionalGenomics #CRISPR #Immunology #Biotech #Cellecta

Cellecta will be at EACR 2026 (June 8–11) at Hungexpo in Budapest—come visit us at Stand 98. 🎤 Industry Spotlight Presentation 🗓 June 10 | 11:10–11:25 More details coming soon. 🗓 Exhibit Hall Hours: • June 16: 12:30–19:45 • June 17: 10:45–19:00 • June 18: 10:45–19:00 Stop by to connect with our team and learn more about our latest tools in functional genomics and cancer research. 🔗 Learn more: cellecta.com/blogs/events-co… #EACR2026 #CancerResearch #FunctionalGenomics #CRISPR #Biotech #Cellecta

Understand how cell populations evolve over time with CloneTracker™ Barcode Libraries. Designed for both in vitro and in vivo studies, this approach enables high-resolution tracking of clonal dynamics across complex biological systems. 🔬 With CloneTracker™, you can: • Label and track individual clones with stable genetic barcodes • Monitor how populations shift under treatment or environmental pressure • Analyze lineage relationships and long-term cell behavior From cancer progression to stem cell differentiation, CloneTracker™ helps uncover the mechanisms driving cellular diversity. 🔗 Learn more: cellecta.com/collections/clo… #CloneTracker #ClonalTracking #CellLineage #FunctionalGenomics #CancerBiology #Cellecta

Turn your CRISPR and shRNA screening data into actionable insights with Cellecta’s Functional Genetic Screening Analysis. Our bioinformatics team uses tools like MAGeCK, DrugZ, and custom pipelines to extract meaningful biology from complex datasets. 🔬 What we help you uncover: • Genes that drive cell viability and phenotype • Interactions between genes and treatments • Key pathways behind your screening results From sample prep and NGS to clear gene- and guide-level outputs, we provide end-to-end analysis designed to support confident decision-making. 🔗 Learn more: cellecta.com/collections/bio… #CRISPR #RNAi #Bioinformatics #FunctionalGenomics #NGS #GeneticScreening #Cellecta