@CE_Leonard

Associate Professor of Epidemiology | UPenn. DU, UPenn, and Yale alum. Opinions own. RT ≠ endorsement.

 Philadelphia, PA
dbei.med.upenn.edu/bio/charles-e-leonard-pharmd-msce
Joined August 2009
  • Tweets112
  • Following406
  • Followers354
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Cooling isn’t a luxury. It’s preventive care for millions living with diabetes and chronic conditions. Fed policy needs to catch up. Proud to share our @statnews op-ed. #extremeheat #healthequity #LIHEAP
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@statnewsMay 14
Access to air conditioning is critical preventive care. But federal policy treats it as optional, write Charles E. Leonard and Anthony Nicome. trib.al/Q31azt6

Access to air conditioning is critical preventive care. But federal policy treats it as optional

Access to air conditioning is critical preventive care. But federal policy treats it as optional, write Charles E. Leonard and Anthony Nicome.

statnews.com
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Charles E Leonard retweeted
Penn CREST@Penn_CREST10 Mar 2025
Great new paper in Clinical Pharmacology & Therapeutics led by doctoral student Haedi Thelen: Characterizing Treatment Effect Heterogeneity Using Real-World Data ascpt.onlinelibrary.wiley.co… @HaediThelen @HennessySean

Characterizing Treatment Effect Heterogeneity Using Real‐World Data

Characterizing heterogeneity of treatment effects (HTE) is a fundamental goal of pharmacoepidemiology, addressing why medications work differently across patient populations. This paper reviews...

ascpt.onlinelibrary.wiley.com
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Exited to share my work at the intersection of real-world evidence, clinical pharmacology, and environmental epidemiology!
Penn Medicine CSO@PennMedCSO12 Nov 2024
Ambient temperature & serious adverse health outcomes among users of different antidiabetes drugs ft. @CE_Leonard, Kacie Bogar, Colleen Brensinger, Warren Bilker, @Alicechencheng & @HennessySean @Penn_CREST @UPenn_CCEB @UPennDBEI @PennSysPharmATT bmjopen.bmj.com/content/14/1…
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Come join our team!
Sean Hennessy@HennessySean11 Nov 2024
We are looking for a research project manager! wd1.myworkdaysite.com/recrui…
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Charles E Leonard retweeted
Penn CREST@Penn_CREST22 Oct 2024
Spotlighting an excellent paper by one of our first-year PhD students, Lin-Chieh Meng! Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study @LinChiehMeng bmj.com/content/387/bmj-2024…

Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan:...

Objective To evaluate the association between paternal metformin use and risk of congenital malformations in offspring. Design Population based, cross national cohort study. Setting Norway and...

bmj.com
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Charles E Leonard retweeted
Penn CREST@Penn_CREST15 Mar 2024
New in Clinical Pharmacology & Therapeutics and led by @Alicechencheng : Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants @HennessySean @CE_Leonard @Miano81 @UPennDBEI ascpt.onlinelibrary.wiley.co…

Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants

Concurrent use of skeletal muscle relaxants (SMRs) and opioids has been linked to an increased risk of injury. However, it remains unclear whether the injury risks differ by specific SMR when...

ascpt.onlinelibrary.wiley.com
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Out now open access: Psychotropic Medication Use in Children and Youth with Autism Enrolled in Medicaid. link.springer.com/article/10… Thanks to our mostly twitterless team led by Jess Rast! With @CE_Leonard @TedBrodkin (1/3).

Psychotropic Medication Use in Children and Youth with Autism Enrolled in Medicaid

Journal of Autism and Developmental Disorders - Children with autism frequently present with complex mental health diagnoses and psychotropic medications are often a component of comprehensive...

link.springer.com
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Come join us! Message me if you’d like further detail!
Sean Hennessy@HennessySean17 Jul 2023
Our group at UPenn is looking for 1-2 postdocs in Real-World Evidence. Please share with those looking for positions. med.upenn.edu/apps/my/bpp_po…
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Pleased to share our @ASCPT_ClinPharm #CTSjournal blog post motivating our #RWE work on antidepressant drug interactions! #TranslationalBytes @Alicechencheng ascpt.org/Journals/CTS/Trans…

More Worldly Antidepressant Drug Interaction Identification

There is a high prevalence of mental illness and substantial utilization of psychoactive prescription drugs (including antidepressants) among Americans. Given the bidirectional relationship between me

ascpt.org
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Excited to share coverage of our work at the intersection of chronic dz epi, environmental epi, and pharmacoepi! @Penn_CREST @HennessySean ldi.upenn.edu/our-work/resea…

People with Type 2 Diabetes and Extreme Temperatures

Extreme outdoor temperatures are known to worsen many chronic medical conditions and now, a new study shows that type 2 diabetes should be added to the list.

ldi.upenn.edu
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Charles E Leonard retweeted
Sean Hennessy@HennessySean4 Jan 2023
Thanks to @PennLDI for featuring work by @CE_Leonard on the joint effects of medications and extreme heat and cold, which are becoming more common with climate change. ldi.upenn.edu/our-work/resea… @UPennDBEI @Penn_CREST

People with Type 2 Diabetes and Extreme Temperatures

Extreme outdoor temperatures are known to worsen many chronic medical conditions and now, a new study shows that type 2 diabetes should be added to the list.

ldi.upenn.edu
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Meet Cheng Chen, our #CTSjournal trainee spotlight. Check her paper: "Antidepressant drug–drug–drug interactions associated with unintentional traumatic injury: Screening for signals in real-world data" #CTSjournal #ASCPTjournalfamily @alicechencheng @UPennDBEI @CE_Leonard
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Charles E Leonard retweeted
SER Publications@epipubs16 Dec 2022
interested in epidemiology #pedagogy? 🎓check out this new @AmJEpi article from @shaharshmuelphd, @CE_Leonard, @KB_Filion, @MarissaSeamans, et al. on the importance of training across subdisciplines to promote better exchanges of ideas @societyforepi doi.org/10.1093/aje/kwac192

Breaking Research Silos and Stimulating “Innovation at the Edges” in Epidemiology

Abstract. Epidemiological training often requires specialization in a subdiscipline (e.g., pharmacoepidemiology, genetic epidemiology, social epidemiology,

academic.oup.com
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Charles E Leonard retweeted
Penn CREST@Penn_CREST21 Nov 2022
On Friday several of our investigators attended the @UPennCEET_CEC Symposium on Climate Change and Human Health. CREST's Kacie Bogar showcased her poster based on our recent Diabetes Care publication (pictured with collaborator @MichelleScience of Yale and @HennessySean)
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@PennPARC Quartet pilot recipient @CE_Leonard published in @DiabetesCareADA "Climate Change and Ambient Temperature Extremes..." funded by @NIA_BSR & was highlighted in the @PennMedBench Oct Newsletter @nia_demography #AmericanDiabetesMonth @AmDiabetesAssn doi.org/10.2337/dc22-1161
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Charles E Leonard retweeted
Shahar Shmuel@shaharshmuelphd7 Nov 2022
Excited to share a new commentary on “innovation at the edges” in epidemiology in @AmJEpi written with an amazing team @CE_Leonard Katsiaryna Bykov @KB_Filion @MarissaSeamans @LundJenny academic.oup.com/aje/advance…

Breaking Research Silos and Stimulating “Innovation at the Edges” in Epidemiology

Abstract. Epidemiological training often requires specialization in a subdiscipline (e.g., pharmacoepidemiology, genetic epidemiology, social epidemiology,

academic.oup.com
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Charles E Leonard retweeted
Sean Hennessy@HennessySean31 Oct 2022
Our new paper (w/ 4 commentaries!) introduces Instrumented Difference-in-Differences, permitting valid inference with milder assumptions than calendar time IV or DiD. Consider if studying an exposure with differential exposure trends by group. onlinelibrary.wiley.com/doi/… @PennCausal

Instrumented difference‐in‐differences

Unmeasured confounding is a key threat to reliable causal inference based on observational studies. Motivated from two powerful natural experiment devices, the instrumental variables and difference...

onlinelibrary.wiley.com
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Charles E Leonard retweeted
Penn CREST@Penn_CREST12 Oct 2022
📝Newly published in American Journal of Epidemiology and lead by @HennessySean and Jesse Berlin: Real-World Trends in the Evaluation of Medical Products academic.oup.com/aje/advance…

Real-World Trends in the Evaluation of Medical Products

Abstract. There is a compelling need to evaluate the real-world health effects of medical products outside of tightly controlled preapproval clinical trial

academic.oup.com
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Excited to share my work on outdoor temp and rates of bad outcomes in T2DM — a wonderfully collaborative effort at the intersection of chronic dz epi and environmental health. diabetesjournals.org/care/ar…

Climate Change and Ambient Temperature Extremes: Association With Serious Hypoglycemia, Diabetic...

Climate change-induced heat waves and environmental factors may contribute to diabetes-related morbidity and mortality. As climate change exacerbates the n

diabetesjournals.org
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Charles E Leonard retweeted
Penn CREST@Penn_CREST21 Sep 2022
✨NEW✨ from the CREST team: Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury @Alicechencheng @HennessySean @DawwasGhadeer @Miano81 @phuongpng @CE_Leonard nature.com/articles/s41598-0…

Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated...

Scientific Reports - Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury

nature.com
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