@CPRD_lit

Publication alert for 'Clinical Practice Research Datalink'. Searches PubMed, MedRXiv, and Arxiv

 East Sussex, England
en.wikipedia.org/wiki/Clinical_Practice_Research_Datalink
Joined January 2021
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Incidence, Prevalence, and Survival of Prostate Cancer in the UK pubmed.ncbi.nlm.nih.gov/3929…

Incidence, Prevalence, and Survival of Prostate Cancer in the UK - PubMed

In this population-based cohort study, incidence and prevalence increased with older age, with high survival rates reflecting a high burden of disease, particularly in the management of cancer...

pubmed.ncbi.nlm.nih.gov
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Excess health care use is significantly and persistently reduced following diagnosis of late-onset epilepsy pubmed.ncbi.nlm.nih.gov/3930…

Excess health care use is significantly and persistently reduced following diagnosis of late-onset...

Health care use demonstrates an acute on chronic rise over the 4 years before diagnosis of LOE. To what extent the partial reversal of the acute pre-diagnosis rise, and the mediators of the acceler...

pubmed.ncbi.nlm.nih.gov
14
Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-linked data pubmed.ncbi.nlm.nih.gov/3928…

Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial...

These results demonstrate variation in drug effects of ACEi and ARB for some outcomes by ethnicity and suggest the potential for adverse consequences from current UK guideline recommendations for ARB...

pubmed.ncbi.nlm.nih.gov
26
Recurrent cardiovascular and limb events in 294,428 patients with coronary or peripheral artery disease or ischemic stroke on antiplatelet monotherapy: The RESRISK cohort study pubmed.ncbi.nlm.nih.gov/3927…

Recurrent cardiovascular and limb events in 294,428 patients with coronary or peripheral artery...

Among a contemporary cohort with cardiovascular disease on APMT, long-term residual atherothrombotic risk remains high despite being on APMT. Greater attention to risk factor control and use of...

pubmed.ncbi.nlm.nih.gov
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Pulmonary fibrosis and lung cancer: an analysis of the Clinical Practice Research Datalink linked to the National Cancer Registration Dataset pubmed.ncbi.nlm.nih.gov/3925…

Pulmonary fibrosis and lung cancer: an analysis of the Clinical Practice Research Datalink linked...

We quantified the proportion of diagnoses of pulmonary fibrosis (PF) among 25 136 people with lung cancer and 250 583 matched controls and compared the natural history of lung cancer in people with...

pubmed.ncbi.nlm.nih.gov
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Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies pubmed.ncbi.nlm.nih.gov/3924…

Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and...

The risk of primary liver cancer was the same in English and Danish patients with ALD cirrhosis, and HCCs constituted 97% of primary liver cancers. Mortality with primary liver cancer was equally...

pubmed.ncbi.nlm.nih.gov
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Is it possible to identify populations experiencing material disadvantage in primary care? A feasibility study using the Clinical Practice Research Database pubmed.ncbi.nlm.nih.gov/3922…

Is it possible to identify populations experiencing material disadvantage in primary care? A...

Data in a major primary care research database do not currently contain a useful measure of individual-level material disadvantage. This represents an omission of one of the most important health...

pubmed.ncbi.nlm.nih.gov
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The association of type 2 diabetes-related characteristics with fracture risk at different sites pubmed.ncbi.nlm.nih.gov/3922…

The association of type 2 diabetes-related characteristics with fracture risk at different sites -...

In conclusion, our study shows that a diabetes duration of 10 years or more, strict glycaemic control resulting in HbA1c levels below 6%, and/or the presence of at least one microvascular complicat...

pubmed.ncbi.nlm.nih.gov
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Time trends in the epidemiology of food allergy in England: an observational analysis of Clinical Practice Research Datalink data pubmed.ncbi.nlm.nih.gov/3921…

Time trends in the epidemiology of food allergy in England: an observational analysis of Clinical...

UK Food Standards Agency and UK Medical Research Council.

pubmed.ncbi.nlm.nih.gov
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Patient pathways for four major chronic respiratory diseases in England between 2008 and 2021 pubmed.ncbi.nlm.nih.gov/3920…

Patient pathways for four major chronic respiratory diseases in England between 2008 and 2021 -...

Current pathways demonstrate missed opportunities to diagnose and manage disease and to improve disease coding.

pubmed.ncbi.nlm.nih.gov
7
An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol pubmed.ncbi.nlm.nih.gov/3920…

An international study to investigate and optimise the safety of discontinuing valproate in young...

Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence...

pubmed.ncbi.nlm.nih.gov
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Comparison of oral anticoagulants for stroke prevention in atrial fibrillation using the UK clinical practice research Datalink Aurum: A reference trial (ARISTOTLE) emulation study pubmed.ncbi.nlm.nih.gov/3920…

Comparison of oral anticoagulants for stroke prevention in atrial fibrillation using the UK...

Analysis of noninterventional data generated results demonstrating noninferiority of apixaban versus warfarin consistent with prespecified benchmarking criteria. Unlike in ARISTOTLE, superiority of...

pubmed.ncbi.nlm.nih.gov
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Risk of unintended consequences from lower antibiotic prescribing for respiratory tract infections in primary care pubmed.ncbi.nlm.nih.gov/3919…

Risk of unintended consequences from lower antibiotic prescribing for respiratory tract infections...

Our results contribute to evidence on the safety of reduced antibiotic prescribing for RTIs in primary care. Results suggest that for the majority of practices, further reductions in RTI-related...

pubmed.ncbi.nlm.nih.gov
6
Impact of moderate-to-high-suicide-intent in major depressive disorder: a retrospective cohort study on patient characteristics and healthcare resource utilisation in England pubmed.ncbi.nlm.nih.gov/3918…

Impact of moderate-to-high-suicide-intent in major depressive disorder: a retrospective cohort...

Patients with MDD and moderate-to-high-suicide-intent were younger, included more males and incurred greater HCRU than those without moderate-to-high-suicide-intent. These results suggest a greater...

pubmed.ncbi.nlm.nih.gov
12
The effect of comorbidities on diagnostic interval for lung cancer in England: a cohort study using electronic health record data pubmed.ncbi.nlm.nih.gov/3917…

The effect of comorbidities on diagnostic interval for lung cancer in England: a cohort study using...

Conditions offering alternative explanations for lung cancer symptoms are associated with increased diagnostic intervals. Clinical guidelines should incorporate the impact of alternative and compet...

pubmed.ncbi.nlm.nih.gov
15
Healthcare utilisation and associated costs for methadone versus buprenorphine recipients: Examination of interlinked primary and secondary care electronic health records in England pubmed.ncbi.nlm.nih.gov/3917…

Healthcare utilisation and associated costs for methadone versus buprenorphine recipients: Examin...

Differences in healthcare utilisation frequency for methadone versus buprenorphine recipients were observed. The differences in associated costs were mainly driven by hospital admissions. These...

pubmed.ncbi.nlm.nih.gov
4
Age and sex specific thresholds for risk stratification of cardiovascular disease and clinical decision making: prospective open cohort study pubmed.ncbi.nlm.nih.gov/3917…

Age and sex specific thresholds for risk stratification of cardiovascular disease and clinical...

This study quantified the potential gains in cardiovascular disease-free life years when implementing prevention strategies based on age and sex specific risk thresholds instead of a fixed risk...

pubmed.ncbi.nlm.nih.gov
8
Incidence, antimicrobial prescribing practice and associated healthcare costs of paediatric otorrhoea in primary care in the UK: A longitudinal population study pubmed.ncbi.nlm.nih.gov/3916…
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Respiratory Syncytial Virus Hospital Admission Rates and Patients' Characteristics Before the Age of 2 Years in England, 2015-2019 pubmed.ncbi.nlm.nih.gov/3916…

Respiratory Syncytial Virus Hospital Admission Rates and Patients' Characteristics Before the Age...

In England, 1 in 91 infants had an RSV-coded admission, likely underestimated by ~3-fold. Most infants were term-healthy infants born before the RSV season. To decrease the total burden of RSV at the...

pubmed.ncbi.nlm.nih.gov
8
The incidence of lung cancer amongst primary care chest radiograph referrals; an evaluation of national and local datasets within the UK pubmed.ncbi.nlm.nih.gov/3916…

The incidence of lung cancer amongst primary care chest radiograph referrals-an evaluation of...

This is the first estimate of the incidence of lung cancer amongst primary care CXR referrals and a demonstration of how the demographic information contained within a request could be used to...

pubmed.ncbi.nlm.nih.gov
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