MD, Nephrology Resident at @policlinicogemelli Currently Research Fellow at Karolinska Institutet Science & Research Enthusiast, Part-time Musician.
Joined October 2023
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🧵1. Aldosterone isn’t just “salt & water.” In modern sodium-rich contexts it drives inflammation, fibrosis, and residual cardiorenal risk. We map physiology → disease → therapies, and argue for reprogramming the signal. Follow the thread ---> doi.org/10.3390/ijms26188829
Hundreds of AI models for SLE. Zero FDA/EMA clearances. One used at point of care.
We asked of each: if it showed up in your clinic tomorrow, what would you do differently?
New review in Lupus, w/ @wisit661 and @FrancescoPesce Pesce.
journals.sagepub.com/doi/10.…
Camillo Tancredi Strizzi retweeted
Now open access in @NDTsocial
CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA
🧐Check also our 2 open access editorials on this innovative concept.
▶️academic.oup.com/ndt/article…
Where does aldosterone actually do its work? In the aldosterone-sensitive distal nephron (ASDN): DCT2, CNT, and the collecting duct.
The control room for Na⁺ balance and K⁺ homeostasis. (Follow the thread 🧵)
#Nephpearls #Nephrology #Physiology
3. Connecting Tubule/Collecting Duct
α-Intercalated cell
🎯 Aldo → H⁺ secretion (H-ATPase/H/K-ATPase)
β-Intercalated cell (base/Cl⁻)
🛑Aldo suppresses Pendrin (Cl/HCO₃ handling)
🧪Aldosterone excess contribute to metabolic alkalosis with hypokalemia.
Full paper available in open access, in collaboration with @Violadmb & @FrancescoPesce.
@IJMS_MDPI
doi.org/10.3390/ijms26188829
7. Future & biomarkers 🔬
Non-genomic pathways (GPER), NLRP3 blockade, TLR/biglycan axis, miRNA, immune re-balancing and others.
👉The goal: pathway-informed, biomarker-guided precision nephrology.
8. Aldosterone: From Essential Tubular Regulator to Pathological Driver—Physiology, Disease, and Therapeutic Advances.
In collaboration with @FrancescoPesce @DAmbrosioViola
Open Access in @IJMS_MDPI:
doi.org/10.3390/ijms26188829
The success paradox: better therapies → rarer events → longer, costlier trials.
Our proposal: smarter trials, not bigger, use adaptive & pragmatic designs, eGFR slope as surrogate, RWE and continue DHT monitoring.
@FrancescoPesce
shorturl.at/yEeC3
Proud to share our new paper: a road map to redesign nephrology clinical trials by pairing modern methodology and computational tools. With @FrancescoPesce.
shorturl.at/kDg50
Camillo Tancredi Strizzi retweeted
Basics of Glomerulonephritis (GN). GBM is key.
All patterns can be explained by glomerular basement membrane (GBM) & type of injury.
Let’s do one at a time
CRESCENTIC GN
1. Results from breach/break of GBM (red arrow)
2. Injury is sudden & severe
Eg-ANCA & anti-GBM GN
Camillo Tancredi Strizzi retweeted
"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. 🧵
