Cancer Cell Invasion lab, Karolinska Institute. Studying how cancer cells invade into their surroundings. One eye on the patient, the other on the cells.
Stockholm, Sweden
Joined June 2022
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1/2 Sometimes, cancer cell invasion fails - and when this happens, the surrounding healthy tissue gets a chance to build a barrier around malignant tumors, leading to a much better prognosis for the patients, as we show in our new study published in @NatureComms.
A new study in @NatureComms shows that a capsule of connective tissue around liver metastases from #ColorectalCancer improves patient survival and represents a healing response by the liver, not a phenomenon caused by the tumor itself. Research by
@Cancer_Invasion et al.
Cancer Cell Invasion lab retweeted
#ScienceSaturday Mutations in cancer cells look “foreign” to the immune system and are excellent targets for T-cells. However, patients with high levels of mutations in their cancers don’t always respond durably to #immunotherapy. @PeterMKWestcott, @LabJacks et al demonstrate that tumor heterogeneity may be the issue, and that mutations that are only in a small population of the #cancer cells (subclonal) are not as correlated with clinical responses compared to mutations that are in all the cancer cells within a tumor (clonal). nature.com/articles/s41588-0…
Cancer Cell Invasion lab retweeted
Great opportunity for a postdoc at @karolinskainst in the Strömblad lab!! This is a very close collaboration with my group #senescence #cancer
ki.varbi.com/en/what:job/job…
Link to the article: nature.com/articles/s41467-0…
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Cancer Cell Invasion lab retweeted
Small dataset from four patients but still useful to #PancreaticCancer researchers - single cell RNA-seq of MATCHED primary tumor & liver metastases. Most published series including our own have been with unmatched primary & metastatic cases. In @NatureComms
nature.com/articles/s41467-0…
2/2 Next, we want to understand how to inhibit invasion by targeting tumor-cell replacement of normal cells.
Thanks a lot to @jengstrand @sparrelid @SaraHarrizi @n_geyer @HpbKarolinska @AndreaCdelVall1 and the other authors for invaluable translational collaborations!
Cancer Cell Invasion lab retweeted
This paper is a great utilization of tens of thousands of freely available annotated #Pathology images that #PathTwitter (or #PathX) has put online over the years on this platform. The training set includes 1000s of images from each subspecialty, including >15,000 images in #GIPath. I found tweets by @ALBoothMD @DraEosina even @ArchivesPath on the training set!
Cc: @KMirza @sanamloghavi @smlungpathguy
Cool stuff! 🔬 🖥️
⚡️Excited to share our new @NatureMedicine paper where we used Twitter to build a vision-language foundation #AI for #pathology nature.com/articles/s41591-0…
We curated >100K public Twitter threads w/ medical images+text to create PLIP for semantic search and 0-shot pred.
All our data (OpenPath): tinyurl.com/openpathdata
Open source PLIP: huggingface.co/spaces/vinid/…
Getting sufficient data is a key bottleneck for medical AI. This work shows how we can harness the tremendous medical knowledge openly shared on social media to develop models. We used multiple filters to improve Twitter data quality. PLIP performs well for 0-shot classifications, fine-tuning, and image and text-based retrievals.
Great work by @ZhiHuangPhD @federicobianchy @mertyuksekgonul and Tom Montine 👏 And thanks to support from @StanfordHAI @StanfordMed!
Cancer Cell Invasion lab retweeted
⚡️Excited to share our new @NatureMedicine paper where we used Twitter to build a vision-language foundation #AI for #pathology nature.com/articles/s41591-0…
We curated >100K public Twitter threads w/ medical images+text to create PLIP for semantic search and 0-shot pred.
All our data (OpenPath): tinyurl.com/openpathdata
Open source PLIP: huggingface.co/spaces/vinid/…
Getting sufficient data is a key bottleneck for medical AI. This work shows how we can harness the tremendous medical knowledge openly shared on social media to develop models. We used multiple filters to improve Twitter data quality. PLIP performs well for 0-shot classifications, fine-tuning, and image and text-based retrievals.
Great work by @ZhiHuangPhD @federicobianchy @mertyuksekgonul and Tom Montine 👏 And thanks to support from @StanfordHAI @StanfordMed!
Cancer Cell Invasion lab retweeted
Are you interested in cancer biology and exploring intratumor heterogeneity and phenotypic plasticity? join our lab! We are recruiting new postdocs!
ki.varbi.com/en/what:job/job…
Cancer Cell Invasion lab retweeted
Excited about #science? Want to develop new models to understand #embryonic #cancer? Like to work with fun people? Then come join our amazing team at @lunduniversity @Lund_Stem as a #postdoc scholar! 👩🏼🔬🧑🏽🔬Help spread the word - forward to colleagues and RT 🫶
Cancer Cell Invasion lab retweeted
Exciting postdoctoral position with immediate start, to explore the immune contexture of the lymph node in aging and cancer 🧐using spatial tissue profiling nature.com/naturecareers/job…
Life-threatening side effects of novel cancer immunotherapies could be treatable - @karolinskainst
Thanks again, @kibiblioteket!
news.ki.se/life-threatening-…
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Cancer Cell Invasion lab retweeted
Happy to announce that our review about systematic inflammatory syndromes (i.e. hemophagocytic lymphohistiocytosis & cytokine release syndrome) has been published in @jitcancer. This will hopefully aid in our understanding of these rare yet potentially fatal adverse events. #ICIs
New #JITC review: Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature bit.ly/3kNBl5j @marcus_skribek
New publication in JITC: jitc.bmj.com/content/11/3/e0…. Rare side effects are hard to study - thankfully, the librarians @kibiblioteket are there to help! After we had met several patients with hyperinflammation after immunotherapy for cancer we wanted to know more... 1/2
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We read thousands of abstracts and extracted data from numerous studies. We found that hyperinflammation is rare but might be more frequent than we thought. Inhibition of IL-6 might be a good treatment option. In for a prospective study?
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Cancer Cell Invasion lab retweeted
New #JITC review: Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature bit.ly/3kNBl5j @marcus_skribek
Cancer Cell Invasion lab retweeted
Are you a #pancreas surgeon? Involved in care of patients after mesenteric vascular resection? Please take a minute to help in this global survey of practice. bit.ly/3UMEsH2
#HPB @aahpbs @EurPancClub @IHPBA @apapancreas @EAHPBA @PancSocGBI