A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
Joined June 2009
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Cell Stem Cell retweeted
Excited to share our new @CellStemCell study from @kochinstitute @MIT: "Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis." Led by two former lab postdocs—Saori Goto (first author) & Nori Goto, now running his own lab. kwnsfk27.r.eu-west-1.awstrac…
Cell Stem Cell retweeted
We are excited to share our latest work, in which we used human PSCs to build human “biological pacemaker” organoids that model the structure and function of the sinoatrial node. This provides a new platform to study pacemaker development, disease mechanisms and drug testing.
Online Now! Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems dlvr.it/TSYZR1 #stemcells
Cell Stem Cell retweeted
20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan
sciencedirect.com/science/ar… by Shinya Yamanaka @CellStemCell
science.org/content/article/…
@ScienceMagazine
Cell Stem Cell retweeted
Thrilled to share our new paper on Cell Stem Cell!🧬
We generated pluripotent stem cell–derived human adrenal tissue with functional zonation, recreating key features of adrenal cortex 3D organization and steroidogenic function.
A powerful new platform to study stem cell biology, adrenal development, disease, and future regenerative therapies.
cell.com/cell-stem-cell/full…
authors.elsevier.com/a/1mjFV…
Kudos to Michinori Mayama and the team for this achievement.
@IRM_UPenn @Penn @pennvet @MayamaMichinori @DavidGStouffer1 @coeff_giving @NIDDKgov @jsps_sns @CellStemCell
Cell Stem Cell retweeted
1st combined human bone & bone marrow organoid platform for modelling blood & immune cell production in a human 3D system. This could be used to model blood cancers and immune disease. From Radcliffe Dept of Med @UniofOxford & published in @CellStemCell rdm.ox.ac.uk/news/new-bone-m…
Cell Stem Cell retweeted
A randomized trial of a stem cell therapy vs placebo for aging frailty showed durable and dose-dependent improvement in the 6-minute walk test @CellStemCell
sciencedirect.com/science/ar…
Cell Stem Cell retweeted
Anti-aging and organ rejuvenation strategies, a review
cell.com/cell-stem-cell/abst… @CellStemCell Figure summary of cellular reprogramming efforts
Cell Stem Cell retweeted
We are delighted to share our newly published Perspective review on microglia replacement in Cell Stem Cell @CellStemCell. This comprehensive article provides an in-depth overview of most key aspects of microglia replacement, including its concept, history, mechanistic principles, implementation strategies, relevant microgliopathies, applications, clinical trial, and future directions.
We hope this review serves as a valuable resource for the community of microglia biology, neuroimmunology, and cell therapy.
Find the full article here:
cell.com/cell-stem-cell/full…
Cell Stem Cell retweeted
Glad to see this work from @AA_Zeng and the team published in @CellStemCell describing a regenerative cardiac–immune crosstalk in neonatal mouse heart, echoes our findings in fish models! Also, thanks to @SheilaChari's invitation to highlight the work in a perspective Preview.😃
Cell Stem Cell retweeted
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L9…
Cell Stem Cell retweeted
Thrilled to share our new paper in @CellStemCell! We present a brain organoid atlas for NDDs, integrating hBO phenotypes, transcriptomics, WES, and brain imaging. We hope this resource inspires new studies and therapies for NDDs!
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L9…
Cell Stem Cell retweeted
Happy to share our Spotlight in @CellStemCell on advances in microglia replacement therapy (Wu et al., Science; Mader et al., Nature) and our perspectives on resilience variants & microglia reprogramming to enhance the “engineering brain sentinels” approach for brain repair.
Cell Stem Cell retweeted
Stem cell research in space: Advancing regenerative medicine beyond Earth! 🚀
Excited to share a new review from our lab at @CSRegenMedicine in @CellStemCell on the rapidly growing field of stem cell research in space.
Read for free below! 📄
cell.com/cell-stem-cell/full…
Cell Stem Cell retweeted
A great piece by our friends at Michigan Medicine! We are grateful to have our first clinical trial in the skilled hands of Drs. Rajesh Rao of Kellogg Eye Center, David Liao of LA Retina and Theodore Leng of Stanford Medicine.
Article | zurl.co/0eUMo
Cell Stem Cell retweeted
Thank you @ScienceMagazine for highlighting our research progress in this news article.
Scientists make most authentic kidney replicas so far | Science | AAAS science.org/content/article/…
Cell Stem Cell retweeted
Our newest human kidney assembloid model features the formation of spatially-patterned human nephrons connected to a central collecting system. It exhibits a variety of kidney functions in vitro and in vivo. Online now in Cell Stem Cell: cell.com/cell-stem-cell/abst…
Cell Stem Cell retweeted
In a Cell Stem Cell paper, a team led by Zhongwei Li @KeckSchool_USC combine kidney filtering & urine-concentrating components to make “assembloids,” lab-grown kidney structures for developing new therapies. @USCStemCell @LiLab_Kidney @CellPressNews stemcell.keck.usc.edu/team-m…
Cell Stem Cell retweeted
By applying our understanding of kidney development, we were able to recapitulate some of the major renal organogenesis in vitro in our new human kidney progenitor assembloid! You can appreciate how the assembloid self-organizes in vitro!
@LiLab_Kidney dlvr.it/TN7QR7
Cell Stem Cell retweeted
We had the honor to preview @TheKingLab's new publication in @CellStemCell; 'Plot Twist: TET2 Clones Save the Brain'. If you are interested in peripheral vs. central immune cells in the brain in health and disease, check it out! sciencedirect.com/science/ar…
Cell Stem Cell retweeted
1/n Fun journey continues: Our new @CellStemCell paper out on how the Inherent & Dormant Plasticity of mouse naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". cell.com/cell-stem-cell/full…
