@wellcometrust Early Career Fellow working on bacterial DNA damage repair @CBCB_Newcastle @UniofNewcastle. @winterhalterlab.bsky.social
Joined April 2014
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Charles Winterhalter retweeted
Come and do a PhD with me and @DrPaulJamesUK to find some new exciting enzymes! #glycotime
findaphd.com/phds/project/ne…
Charles Winterhalter retweeted
If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
Charles Winterhalter retweeted
Using cryoEM we understood the structural basis of chiral DNA wrap by bacterial gyrase (and also produced the most complete/highest resolution E coli gyrase model to date).
@JohnInnesCentre @DurhamU34989 @MCB_UJ
Charles Winterhalter retweeted
2 weeks to go! Apply for the 2 posts by Nov 25th - pls RT!
We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
Charles Winterhalter retweeted
We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! @Sheffield_AFM @Olulana4
doi.org/10.1126/scienc…
Charles Winterhalter retweeted
As well as improving our daily lives, university research contributes £54 BILLION to the UK economy and supports 121k jobs across the UK📈
If we want to be a country fit for the future, the government must make research funding more sustainable👇
loom.ly/T-7pw68
Charles Winterhalter retweeted
DTP PhD studentship available in our lab. Start: Oct 2025. Apply: now-24th Nov 2024
Taming the Viral Wolf: Cracking the Code of Gene Transfer Agents in Bacteria.
Please RT. Thank you!!!
shorturl.at/sR2px
Charles Winterhalter retweeted
Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular development and antibiotic production in Streptomyces.
Postdoc: shorturl.at/f8NTN
PhD position: shorturl.at/qCFmN
Email me for more information.
Charles Winterhalter retweeted
A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to @pavani_raphael, @TripathiVeenu, and many terrific collaborators including @FrogWalterLab, @CejkaLab, @weiwsmiling. See science.org/doi/epdf/10.1126…
Charles Winterhalter retweeted
A rewarding collaboration revealing an entirely novel inhibitor pocket in DNA gyrase. Inhibition mechanism determined via beautiful biochemistry experiments by @leela_bg - well done Leela! Thanks to @yushuv @AstburyCentre for the final EM data collection 👍
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Charles Winterhalter retweeted
Our work on elucidating transcriptional control of Gene Transfer Agents GTA in Caulobacter crescentus is finally published… nature.com/articles/s41467-0…
Charles Winterhalter retweeted
It's time for a new era of ambitious global action on antimicrobial resistance (AMR).
The cost of inaction is too high.
Political leaders must set bold targets and establish better ways to monitor evidence and progress.
Read our recommendations ⤵️
wellcome.org/reports/driving…
Charles Winterhalter retweeted
A paper in @NatureComms describes a type of plastic embedded with microbes that can help to rapidly degrade it after coming into contact with soil. go.nature.com/4dkocXB
ALT This is a cartoon depiction of the process. Credit: Han Sol Kim
Charles Winterhalter retweeted
A structure of gyrase with chirally wrapped DNA from myself & @HeddleLab. This requires some history dive to explain...(🧵)
biorxiv.org/content/10.1101/…
Charles Winterhalter retweeted
Antibiotics help to prevent and treat infections.
We need a pipeline of new ones to fight infections because over time they become resistant to the drugs we use to treat them.
Yet, no new classes of antibiotics have been approved since the 20th century. [1/3]
ALT Bar chart titled: Why is it so hard to develop new antibiotics? The chart shows the number of antibiotics approved each decade starting from the 1990s to the 2020s. One antibiotic was discovered in the 1900s, zero in the 1910s, one in the 1920s, one in the 1930s, seven in the 1940s, nine in the 1950s, five in the 1960s, five in the 1970s, two in the 1980s, zero in the 1990s, 2000s and 2010s. There is a question mark on the 2020s. The source for the data is Pew Charitable Trusts, adapted from Silver LL. Challenges of Antibacterial Discovery, Clinical Microbiology Review 2011.
Charles Winterhalter retweeted
Nature research paper: Emergence of fractal geometries in the evolution of a metabolic enzyme go.nature.com/3TQ8BX3
Charles Winterhalter retweeted
Bioimaging allows researchers to visualise biological life and reveal the mechanisms underlying health and disease.
These images show researchers analysing neuroimaging data, a scan of a zebrafish brain and an image of a zebrafish eye captured using confocal microscopy. [1/2]
ALT Two researchers in white lab coats look at neuroimaging on a computer screen.
ALT A microscopy image of a zebrafish eye, showing fluorescent red and blue structures on a black background.
ALT A scan of a zebrafish brain on a computer screen.
Charles Winterhalter retweeted
🔬Exciting Opportunity! 🌐Join us at @kavlioxford in a mission to unravel gene expression inside the jungle of live cells! Intrigued by single molecules, RNA, condensates, AI and bacteria? Read on! 🚀Two 4-year positions. RT pls! #ScienceJobs #Postdoc #bacteria #singlemolecule🌟
Charles Winterhalter retweeted
Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: nature.com/articles/s41586-0…
Charles Winterhalter retweeted
We are looking for a Postdoctoral Research Associate with expertise in cryo-EM/cryo-ET to join our lab at @QMULSciEng . This @wellcometrust funded post is aimed at studying the DNA replication initiation mechanism in bacteria. Please RT.
qmul.ac.uk/jobs/vacancies/it…