@ChemKu

Department of Medicinal Chemistry, University of Kansas - Lawrence

 Lawrence, 66045 Kansas
medchem.ku.edu/
Joined May 2017
  • Tweets114
  • Following14
  • Followers109
15Media
The Department is happy to announce the promotion of Dr. Mark Farrell and Dr. Shyam Sathyamoorthi to the rank of Associate Professor. Congratulations!
2
1
9
281
One more cover for the virtual wall: Farrell lab!
2
Our virtual departmental wall was enriched substantially in the last few months with journal cover art highlighting recent publications from our faculty. Thread! 1/4
1
5
more replies
Boskovic Lab! 3/4
1
2
Bloom Lab! 4/4
2
Prof. Emeritus Bob Hanzlik invested 49 years in the School of Pharmacy. His passion for mentoring students and junior faculty made an exponential impact in the pharmacy community. Former students, colleagues and others are now giving back. Read more rockcha.lk/32w #KURx
2
1
3
Welcome to another awesome pair of issues from @JOC_OL! This time in #JOrgChem we feature a cool cover of a “blueprint” for synthesizing complex lactones pubs.acs.org/toc/joceah/87/2…. Meanwhile in #OrgLett we present a unique dihomohalogenation methodology pubs.acs.org/toc/orlef7/24/4… 😃
8
21
Congratulations to Boskovic lab team for this new publication in @angew_chem in which they literally shine light on small heterocyclic ketones.
Zarko Boskovic@djavko18 Nov 2022
I am very proud to share our most recent work, now accepted in @angew_chem. Good work @mannpharm, @pawandhote1 et al. Photochemical Decarbonylation of Oxetanone and Azetidinone: Spectroscopy, Computational Models, and Synthetic Applications onlinelibrary.wiley.com/doi/…

Photochemical Decarbonylation of Oxetanone and Azetidinone: Spectroscopy, Computational Models, and...

Upon irradiation with UV light, strained heterocyclic ketones expel carbon monoxide through a Norrish type I mechanism. Ylides formed in this way cyclize with a variety of double bonds.

onlinelibrary.wiley.com
Making cyclic peptides through a "Snip&stitch" strategy developed by the Bloom Lab.
ACS Central Science@ACSCentSci1 Nov 2022
Late-stage skeletal editing of peptide −SS− bonds through bis-dehydroalanine intermediates provides ready access to chemically unique −CC− carbocycles with enhanced biopharmaceutical properties go.acs.org/2EC NEW #ASAP by Steven Bloom & Samuel Gary @ChemKu
3
Congratulations to our 2022 Smissman awardee, Prof. Craig Crews! Thank you for the two invigorating lectures and a day of wonderful interactions with students and faculty.
Craig Crews@CraigMCrews22 Oct 2022
It was an honor to give this year's Smissman Memorial Lecture and I owe a big thank you to the KU Medicinal Chemistry Department for hosting me!
1
1
Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans pubs.acs.org/doi/10.1021/acs…

Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans

Abstract. The abundance of sialic acid-containing glycans in the glycocalyx of malignant cells enables immune evasion. Here, we leverage the biosynthetic p

pubs.acs.org
Highly Stereospecific Cyclizations of Homoallylic Silanols pubs.acs.org/doi/10.1021/acs…

Highly Stereospecific Cyclizations of Homoallylic Silanols

Abstract. We demonstrate that di-tert-butylsilanols are competent nucleophiles for the intramolecular interception of palladium π-allyl species. In these r

pubs.acs.org
Ring Opening of Aziridines by Pendant Silanols Allows for Preparations of (±)-Clavaminol H, (±)-Des-Acetyl-Clavaminol H, (±)-Dihydrosphingosine, and (±)-N-Hexanoyldihydrosphingosine pubs.acs.org/doi/10.1021/acs…

Ring Opening of Aziridines by Pendant Silanols Allows for Preparations of (±)-Clavaminol H,...

Abstract. We present a unique strategy for the synthesis of vicinal amino alcohols. Ring opening of aziridines with pendant silanols is compatible with a r

pubs.acs.org
Congratulations to the freshly minted PhD from the department! Good luck at Scripps.
FarrellLab@farrellglycolab22 Sep 2022
#1
The department celebrated 49 years of Prof. Robert Hanzlik's impact on science and community @UnivOfKansas with a symposium and a banquet. Congratulations, Bob!
1
9
Congratulations to @pross1193 on a successful PhD Defense today. To say I’m proud is an understatement. The body of innovative research that Pat completed is so impressive. Looking forward to seeing what Pat gets up to with @daniel_murin and beyond! @FarelChemImmuno PhD #1
1
2
2
22
Target ID of small molecules using CRISPR: new technology from the Wang lab. Read in @ACSCentSci pubs.acs.org/doi/10.1021/acs…

Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform

Abstract. Small-molecule drug target identification is an essential and often rate-limiting step in phenotypic drug discovery and remains a major challenge

pubs.acs.org
Congratulations to @Farrellglycolab members and @MarkPFarrrell for their most recent publication in ACS Chem Biol: Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans pubs.acs.org/doi/10.1021/acs…

Directing CAR NK Cells via the Metabolic Incorporation of CAR Ligands into Malignant Cell Glycans

Abstract. The abundance of sialic acid-containing glycans in the glycocalyx of malignant cells enables immune evasion. Here, we leverage the biosynthetic p

pubs.acs.org
5
Boskovic lab @chemku reporting in J. Org. Chem. @JOC_OL their efforts to reach complex structures in short order from simple precursors.
J Org Chem/Org Lett@JOC_OL24 May 2022
Spirocyclic azetidine-lactones in a 7-step process with two key photochemical reactions: aza-Yang cyclization to make azetidinols and Buchner insertion of carbene into an aromatic ring to make lactone and cycloheptatriene. In #JOC from @djavko et al. pubs.acs.org/doi/10.1021/acs…
2
5
Load more