We are excited to announce that Olena Mishchuk and Inna Volkova will be attending the BIO KOREA 2025 International Convention! You can find the Chemspace Team at booth #N16 - stop by and let’s connect! Do not miss the chance to explore: - How our services are accelerating early-stage drug discovery - The world’s largest catalog of building blocks, screening compounds, and biologics - Our end-to-end solution – the Purchasing Software as a Service, designed to simplify and speed up your procurement process ✉️ Want to book a one-on-one meeting? Reach out to us at [email protected] - we would love to talk! #biokorea2025 #conference #drugdiscovery #connection #chemspaceteam

Suzetrigine (VX-548, Journavx®), the first-in-class oral NaV1.8 inhibitor developed by Vertex Pharmaceuticals and approved by the FDA in January 2025, was named Molecule of the Year 2024 by Drug Hunter. To support further exploration of NaV1.8 channel inhibition as a novel analgesic strategy, we have designed a focused set of Suzetrigine analogs: lnkd.in/eSJ9b8zN The NaV1.8 voltage-gated sodium channel plays a critical role in pain signal transduction. Through selective targeting, suzetrigine provides effective pain relief without the CNS-related side effects or addiction risks associated with opioids. Clinical trials have demonstrated significant pain reduction across multiple acute pain conditions with a favorable safety profile, which highlights NaV1.8 as a validated target for next-generation analgesics. 📩 We welcome collaborations to evaluate suzetrigine analogs further and explore new therapeutic opportunities in pain research. For orders and inquiries, contact us at [email protected]. #drughunter #molculeoftheyear #chemicalcatalog #drugdiscovery

Now you can search across 142 billion molecules - easily and free of charge! We are excited to introduce a brand-new search portal for Freedom Space 4.0, developed by the Chemspace team: freedom.chem-space.com/ What makes it special? - Synthon-based search — explore vast chemical space with ease - Exact and substructure search options - Single and multiple query support This tool was built with flexibility and speed in mind to help you explore one of the largest virtual spaces available today. So what are you waiting for? Try it out and experience the power of Freedom Space 4.0 at your fingertips. More about Freedom Space 4.0: freedom.chem-space.com How the synthon-based search works: youtu.be/L5RrhjqUJ9M

Join Mykola Protopopov, PhD, online at the Conscience Symposium on April 7-8 in Montreal! He will reveal key insights and approaches from CACHE Challenge #2, where the Chemspace team ranked in the top 5! Register by April 2 to secure your spot: event.fourwaves.com/conscien… #chemspace #consciencesymposium #cachechallenge

Protein kinases are among the most promising drug discovery targets. The human genome encodes approximately 518 protein kinases. As of recent data, over 100 kinase inhibitors have been approved for clinical use. This suggests that a significant portion of the human kinome remains unexplored, indicating substantial opportunities for drug discovery within this class. Chemspace Computational Services team designed a structurally diverse Protein Kinases Targeted Library. General Protein Kinases Library – 20,091 compounds against 79 targets from 52 families Allosteric Protein Kinases Library – 12,138 compounds against 36 targets from 28 families More about how we did it here: chem-space.com/compounds/pro… We also offer the generation of targeted libraries using known ligands and analog similarity search by USRCAT, as well as methods with Morgan FP and E3FP. Besides that, docking services are available upon request. Get in touch at [email protected] to learn more!

Do not miss the chance to meet us in San Diego! We are excited to announce that Olga Tarkhanova, PhD and Uliana Matviienko will be participating in the ACS Spring Meeting 2025 in San Diego from March 23-27, presenting two talks in the main technical program. 📌 Presentation 1: Discovering ligands targeting the conserved RNA binding site of SARS-COV-2 NSP13 Date: March 23, 2025, Sunday Time: 5:15 PM - 5:30 PM Location: Room 33A, San Diego Convention Center Session name: Drug Design 📌 Presentation 2: Ml-assisted generation and exploration of the Freedom space: A freely-available dataset of synthetically accessible molecules Date: March 24, 2025, Monday Time: 11:15 AM - 11:35 AM Location: Hall B-1, Room 4, San Diego Convention Center Session name: Machine Learning and AI for Organic Chemistry Want to schedule a one-on-one meeting with us? Contact us at [email protected]. See you in San Diego!

Still not registered? Do not wait - follow the link now! zoom.us/webinar/register/WN_… 📅 Join us on March 13th for an exclusive webinar with Olga Tarkhanova, PhD, and David Cosgrove, PhD. What’s in it for you? - Explore the new RDKit search for synthon-based spaces - Dive into Freedom Space 4.0 - featuring 142 billion synthesizable molecules - Get insights into our custom space generation workflow with ML-based filters Secure your spot today! #webinar #chemicalspace #exploration #142billionmolecules

Three years of pain. Three years of strength. Three years of fighting for our future. We have lost so much, yet we stand. We have been tested, yet we endure. Every day, we prove that no force can break us. We work, we build, we believe - because we are Ukrainians. Because giving up has never been an option. Through every challenge, we rise. Through every hardship, we grow stronger. We carry the weight of history on our shoulders, but we walk forward with pride. Ukraine, we stand. Slava Ukraini! 💙 💛

We are thrilled to be a sponsor of Bio-IT World Conference & Expo 2025! 🎉 Join us on April 2-4 in Boston, MA, where you can meet our team - Olga Tarkhanova, Uliana Matviienko, Aliona Savitch, and Inna Volkova - and dive into exciting discussions about drug discovery. The best part? The most interesting is yet to come! Stay tuned - we will soon reveal the research project we will be presenting. Plus, as a sponsor, we have an exclusive promo code for $200 OFF your registration! Drop us a line at [email protected] to get yours. See you in Boston! #BioITWorld #Chemspace #DrugDiscovery

Great news! Freedom Space 4.0, encompassing 142 billion synthetically accessible molecules, is now searchable through Alipheron's advanced tools: Hyperspace and Pharos-3D. 📍 Hyperspace enables ultra-fast searches within vast chemical spaces using superstructure and similarity search options. 📍 Pharos-3D screens ultra-large combinatorial spaces to identify molecules with similar shapes and pharmacophore profiles to your query structure. More details here: chem-space.com/freedom-space #chemicalspace #142billionmolecules #hitdiscovery

We are thrilled to invite you to our upcoming webinar: “A Journey Into the Freedom Space of 142 Billion Molecules”! 🌟 Do not miss out - register now and be part of the discovery: zoom.us/webinar/register/WN_… The speakers are: Olga Tarkhanova, PhD and David Cosgrove, PhD. The webinar will cover: - New RDKit search of synthon-based spaces - Introduction of the latest version of Freedom Space with 142 billion molecules - Unique workflow of custom space generation #chemspace #webinar #freedomspace #synthons #newsearch #medicinalchemistry

Freedom Space 4.0 is now fully accessible within BioSolveIT’s computational tools! You can explore this ultra-large chemical space of 142 billion molecules using: - infiniSee – chemical space navigation platform. - SeeSAR’s Chemical Space Docking™ - advanced structure-based virtual screening method. Freedom Space 4.0 is designed to streamline your hit discovery workflows by solving the problem of synthetic accessibility. How? By leveraging advanced ML-based filters and synthesis success rate data obtained from years of operation of REAL Space. The result? 142 billion molecules with over 80% synthesis success rate! More details here: tinyurl.com/45premrp #freedomspace #chemicalspace #science #drugdiscovery

On this International Day of Women and Girls in Science, we want to take a moment to recognize and appreciate the incredible women in science everywhere, who bring their expertise and dedication every day. At Chemspace, we are proud to have many talented women on our team and are grateful for their invaluable contributions to the drug discovery process. Their knowledge, commitment, and innovative thinking drive progress in the field. 💚 To all women and girls pursuing careers in science: your contributions matter! Your ideas inspire change. Keep exploring - your potential is limitless! 🔥 #chemspace #girlsinscience #medicinalchemistry #womeninscience #nationalday

Here is a summary of all Chemspace news and highlights for January, in case you missed it: 💡 Updates&Collaborations: - Introducing Freedom Space 4.0! tinyurl.com/bdhuth8h - Introducing Biologics Update! - Transforming Computational Drug Discovery: Chemspace and Fovus - Chemspace Join the “Partners in Research” Programme by EFPIA! 📌 News: - Key Milestones We Achieved Together in 2024! - 2025 Conference Planning Checklist! 🧬 Biologics for Research: - Microtubule-Associated Protein Tau (MAPT) 🔍 Building Blocks and Screening Compound Sets: - Analogs to New Biological Tool Compounds - Crinecerfont! #chemspace #medicinalchemistry #science #researchanddevelopment #drugsynthesis #scienceandtechnology #research #drugdiscovery #chemicals #buildingblocks #scienceexperiment #medicinalchemistry #synthesis #organicchemistry #researcher #chemicalindustry

CRENESSITY™ (crinecerfont), the oral antagonist of the corticotropin-releasing factor type 1 receptor (CRF1), was approved by the FDA in December 2024 as the first new therapy in 70 years for classic congenital adrenal hyperplasia (CAH) and represents a significant breakthrough in managing this rare genetic condition. 🎯 o further study the therapeutic potential of CRF1 receptor antagonism, we have created a set of analogs for сrinecerfont. tinyurl.com/3hehzkmp CRF1 receptors are pivotal in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is dysregulated in CAH. By inhibiting CRF1, сrinecerfont reduces excessive adrenocorticotropic hormone secretion, offering a non-glucocorticoid mechanism that can reduce the side effects of traditional high-dose steroid therapy. Clinical trials have demonstrated significant reductions in adrenal androgens and androgen precursors in both adult and adolescent patients with classic CAH. ✉️ We invite collaboration to study these promising crinecerfont analogs. For orders and inquiries, please get in touch with us at [email protected]. #chemspace #drugdiscovery #medicinalchemistry #smallmolecules #buildingblocks #chemistry #LifeSciences #research #Science #scienceandtechnology #researchanddevelopment #drugsynthesis

More molecules, more freedom, more discovery - meet the NEW Freedom Space 4.0! 🚀 With expanded diversity and AI-driven filtering of building blocks, this latest version is designed to facilitate your hit discovery workflows by solving the problem of synthetic accessibility. What makes the new Freedom Space a must-have for drug discovery? 📍 Ultra-large chemical space with 142 billion molecules 📍 Synthesis success rate over 80% 📍 Refined ML-based filters for building block selection 📍 Presented in subsets (synthon-based space, Ro5, and Beyond Ro5 subsets) Are you ready to explore the next generation of chemical spaces? Discover more here: tinyurl.com/yc8e6z68

We are thrilled to share our conference lineup for February through June! Chemspace is gearing up for an incredible start to 2025. Here’s where you can find us: 📍 ACS Spring USA – San Diego, March 23–27 📍 CHI's 24th Annual Bio-IT World USA – Boston, April 2–4 📍 Bio Korea 2025 – May 7–9 📍 BioMed Israel – Tel Aviv, May 20–22 Join us to explore the future of drug discovery, connect with industry leaders, and discover how Chemspace is shaping the path forward. Heading to any of these events? Let’s meet! Drop us a message at [email protected] or connect in the comments. See you soon! 😃 #chemspace #drugdiscovery #medicinalchemistry #smallmolecules #buildingblocks #events #LifeSciences #research #Science #scienceandtechnology #researchanddevelopment #conferences2025

We at Chemspace are thrilled to join EFPIA and its “Partners in Research” initiative! 🔥 We look forward to designing and implementing new R&D that will not only advance scientific discovery but also deliver integrated healthcare solutions to benefit patients and society. 📍 The European Federation of Pharmaceutical Industries and Associations (EFPIA) represents the biopharmaceutical industry operating in Europe. EFPIA brings together 37 national associations, 40 leading pharmaceutical companies, and a growing number of SMEs to foster innovation, enabling the discovery, development, and delivery of new therapies and vaccines across Europe. 📍 "Partners in Research" is an entity for companies in research-related sectors, dedicated to advancing the life science environment in Europe. It aims to integrate diverse technologies and sciences to tackle unmet medical needs and unlock the immense potential of scientific innovation for health. #chemspace #drugdiscovery #medicinalchemistry #smallmolecules #buildingblocks #EFPIA #LifeSciences #research #Science #scienceandtechnology #researchanddevelopment #partnership

In 2024, Microtubule-Associated Protein Tau (MAPT) has been a major focus in neurodegeneration research. To support advancements in this field, we have curated a set of Chemspace Biologics (tinyurl.com/2t7tbure). 🧬 Tau primarily expressed in neurons, stabilizes microtubules, essential components of the cytoskeleton. In conditions like Alzheimer's and frontotemporal dementia, its hyperphosphorylation leads to neurofibrillary tangles that disrupt cellular function and contribute to neuronal death. Emerging evidence also suggests Tau's involvement in the progression of various cancers. As a key player in the development of severe serious conditions, Tau is a vital research target. The Chemspase proposes high-quality antibodies, peptides, proteins, clones, kits, and RNAs to investigate this protein's role in pathological and physiological processes. ✉️ If you're interested in Tau or other targets or wish to explore our biological services, contact us at [email protected]. We’re here to support your research journey. #chemspace #drugdiscovery #medicinalchemistry #smallmolecules #buildingblocks #chemistry #LifeSciences #research #Science #scienceandtechnology #researchanddevelopment #drugsynthesis

We are excited to announce the launch of our brand-new Biologics webpage on Chemspace’s website! 🎯 Thanks to Chemspace’s close collaboration with trusted CRO partners in Biologics R&D, we now offer a comprehensive range of services for custom product development. Our reliable partners bring long-standing expertise in: ✅ DNA&RNA Oligonucleotide Synthesis ✅ Recombinant Protein Expression ✅ Development & Production of Diverse Antibody Formats Explore more here: tinyurl.com/mwx3bsu5 💚 #chemspace #drugdiscovery #medicinalchemistry #smallmolecules #buildingblocks #chemistry #LifeSciences #research #Science #scienceandtechnology #researchanddevelopment #drugsynthesis #biologics #antibody