@ChrisJWan

Synbio, origins of life. Postdoc @TheCrick Previously PhD student @MRC_LMB, undergraduate @CamBiochem

Joined November 2020
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Monthly net salary 2005 DR - £2,168 MP - £2,293 2023 DR - £2,108 MP - £4,939 This is why I support the #DoctorsStrike And last year over 7,000 doctors left the UK for better paid jobs overseas. If you want to save the NHS, you too should support the strike.
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My PhD work is published today in Molecular Cell!! 🥳 A short thread 🧵 (1/12) cell.com/molecular-cell/full… #phosphatase #DNAreplication #cellcycle #PP2A #originfiring

Dephosphorylation of the pre-initiation complex is critical for origin firing

Across eukaryotes, cyclin-dependent kinase (CDK) activates replication initiation by phosphorylating two substrates, Sld2 and Sld3. Here Jenkinson et al. show that the reverse reaction, dephosphory...

cell.com
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Self-replication is a defining hallmark of all living systems and how it emerged - early on in the origin of life - remains a fundamental question in biology and chemistry. Postdoc opportunity in my lab: nature.com/naturecareers/job… Please RT!
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🚨New paper in @NatureChemistry w/ @PhilHolliger joint 1st w/ brill saxophonist & bowtie fan @Niklas_Freund1 We describe a polymerase for efficient DNA-templated synthesis of 2’OMe- & MOE-RNA & develop biostable aptamers & RNA-cleaving 2’OMezymes #synbio nature.com/articles/s41557-0…

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyet...

Nature Chemistry - Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation...

nature.com
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The Crick is a spectacular place to start an academic career. Most generous startup resources in the world, outstanding (and very new) facilities, no obligation to teach. Everyone who wants to start an academic bio lab should apply.
The Francis Crick Institute@TheCrick1 Sep 2022
Come start your group at the Crick! 💡 We're looking for creative researchers from all areas of biology and biomedicine to join our early career faculty community. #AcademicJobs | #ECRChat Learn more and apply by 6 October ⤵️ crick.ac.uk/careers-study/fa…

Early career group leaders

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

crick.ac.uk
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New paper with @Taylor_Lab_Cam and @PhilHolliger! We evolve an RNA-cleaving FANAzyme that can be programmed to cut any RNA transcript. Upon delivery into cells, we demonstrate allele-specific RNA knockdown - cutting oncogenic KRAS transcripts whilst leaving wild-type KRAS intact!
Alex Taylor@Taylor_Lab_KCL5 Sep 2022
🚨Article in @NatureChemistry w/ @PhilHolliger @ChrisJWan Using test tube evolution of synthetic nucleic acids we engineer artificial RNA-cutting oligo enzymes that cleave transcripts in cells w/single-nucleotide precision #synbio chemistrycommunity.nature.co… & nature.com/articles/s41557-0…
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Chris Wan retweeted
SheqLab@ShechnerLab25 Aug 2022
I want to formally thank @mcrae_ewan, @PhilHolliger and colleagues for—after 22 years—*finally* completing my PhD thesis project. 😅 Stunning, absolutely gorgeous work. Congrats to the whole team!!!
cryoEM Papers@cryoEM_Papers24 Aug 2022
Cryo-EM structure and functional landscape of an RNA polymerase ribozyme biorxiv.org/cgi/content/shor…
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Happy to share our preprint based on an exciting collaboration with @PhilHolliger. Thanks to the team for making it happen: @mcrae_ewan, @ChrisJWan, @EmilLK2, Kalinka Hansen, @edo_gia, @isaac_sur, @joe_curran1 and @DrJamesAttwater. biorxiv.org/content/10.1101/… – at Arhus, Denmark

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

The emergence of an RNA molecule capable of replicating itself and other RNA sequences is a central pillar of hypotheses regarding the origin of life[1][1],[2][2]. In vitro evolution has yielded...

biorxiv.org
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The first preprint from my PhD is now live! biorxiv.org/content/10.1101/… a short thread 🧵 (1/n)

Cryo-EM structure and functional landscape of an RNA polymerase ribozyme

The emergence of an RNA molecule capable of replicating itself and other RNA sequences is a central pillar of hypotheses regarding the origin of life[1][1],[2][2]. In vitro evolution has yielded...

biorxiv.org
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This has been a wonderful collaboration with @mcrae_ewan, with contributions from @EmilLK2, Kalinka Hansen, @edo_gia, @isaac_sur, Joe Curran, @DrJamesAttwater, and co-supervised by @PhilHolliger and @esandersen. (8/8)
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Didn’t realise you were on Twitter @joe_curran1 ! :)
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