City of Hope is a National Cancer Institute-designated comprehensive cancer center for cancer, diabetes and other life-threatening diseases.
Duarte, CA
Joined January 2009
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Ending cancer starts with Hope. 💙
For our patients, it means more time with loved ones, more milestones to celebrate and more hope. For our physicians, researchers and care teams, it's a reminder: when cancer shows up, we show up stronger.
City of Hope retweeted
At #ESMO26, Rahul Winayak, MD (@cityofhope) explains new metastatic #RCC targets—GPR65, HPK1, ENPP3, CD70—that aim to overcome #immunotherapy resistance.
🎥 WATCH: targetedonc.com/view/rahul-w…
#KidneyCancer #Oncology | @RWinayak @CityofHope_GU
City of Hope retweeted
Huge congrats to @hoperugo @cityofhope on her presentation at #ESMO26 of the final analysis of #KNB49 & simultaneous publication in @Annals_Oncology! @OncoAlert
City of Hope retweeted
Exciting to see novel immune-engaging strategies in RCC. XmAb819, ENPP3×CD3 bispecific T-cell engager, showed activity in heavily pretreated ccRCC, highlighting potential of ENPP3 as a therapeutic target beyond VEGF, IO, HIF-2α pathways. #ESMO2026 @montypal @cityofhope @OncoAlert
City of Hope retweeted
Eager to meet folks at the @cityofhope booth (Hall 8, #8038) Sunday at 1 pm here at #ESMO26! If you are interested in careers in #oncology, we would love to meet you! Here now with @DaniCastilloMD & @RWinayak!
City of Hope retweeted
Resistance post IO in mRCC remains a challenge. ENPP3 is a novel target expressed highly in ccRCC.
Ph 1 study of Xmab819 (ENPP3 x CD3) by @montypal shows compelling ORR at 45.5% and DCR at 81.8% in heavily pre-treated population.
Dose-dependent efficacy and side effects (CRS, rash) tail off after priming doses.
#ESMO26
@RWinayak – at Madrid, Spain
City of Hope retweeted
#ESMO26 Building upon options for our patients with #ColorectalCancer.
Our CLOVER☘️Trial
CCR5-targeting
Leronlimab with
Oral chemotherapy &
VEGF-inhibitor
Enriched
Regimen
#ctDNA reductions compared to real world+dose response
@OncoAlert @cityofhope
@benweinbergmd today!
City of Hope Atlanta's Irati Rodríguez-Matesanz, MSN, FNP-BC, previews her presentations at #ESMO26 and shares why collaboration across institutions is key to advancing cancer research.
City of Hope retweeted
At #ESMO26 we had the pleasure of interviewing Matthew Lee (@cityofhope) who discussed the development of BG-C477, a CEA-targeting ADC, and early results in non-small cell lung cancer. He also explores how CEA compares with established NSCLC ADC targets, and whether its expression and internalisation support efficient payload delivery 🎯🫁
Coming soon to VJOncology.com 👀
#LungCancer #NSCLC #ADC @myESMO
City of Hope retweeted
CD70. ENPP3. HPK1. GPR65. All promising targets in #kidneycancer, but what is know about their prognostic/predictive value? Are they enriched in pts with angiogenic or immunogenic profiles? My brilliant @cityofhope postdoctoral fellow @RWinayak takes aim at these questions in his #ESMO26 poster. Do stop by!
@AndreaNecchi @tompowles1 @brian_rini @DrChoueiri @shilpaonc @apolo_andrea @TDorffOnc @neerajaiims @PGrivasMDPhD @g_procopio_ @gbanna74 @ravikanesvaran @OncoAlert
Excited to share our #ESMO26 abstract on emerging targets in mRCC. Analysis of 2,134 RCC transcriptomes identified immunogenic (GPR65/HPK1) and angiogenic (ENPP3/CD70) programs linked to improved outcomes with IO vs non-IO therapy, informing future combination strategies.
City of Hope retweeted
Excited to share our #ESMO26 abstract on emerging targets in mRCC. Analysis of 2,134 RCC transcriptomes identified immunogenic (GPR65/HPK1) and angiogenic (ENPP3/CD70) programs linked to improved outcomes with IO vs non-IO therapy, informing future combination strategies.
City of Hope retweeted
Thank you to @RWinayak of @cityofhope for sharing insights from research on novel target expressions in renal cell carcinoma, being presented at @myESMO #ESMO26
Join us Nov. 13 for City of Hope’s 7th annual virtual Diabetes & Cancer Interface Symposium, exploring the connections between obesity, diabetes and cancer.
This year’s theme: Nutrition, Microbiome and Cancer.
Free and open to registered participants: bit.ly/4ieqOts
City of Hope retweeted
We're being taken over! During #ESMO26, follow along as #oncology experts take over OncLive's social accounts and share exclusive insights from @myESMO in Madrid.
Stay tuned all meeting for updates from @GhosnMd, @RWinayak, @benweinbergmd, and @maryam_lustberg
#ESMO26: Join City of Hope's Hope Rugo, M.D., (@hoperugo) for a full slate of sessions and presentations exploring the latest advances in breast cancer research and care.
Learn more about Dr. Rugo: bit.ly/4dN2620
Join City of Hope's @TDorffOnc @montypal and @PDZOnc for a virtual discussion on advances in kidney and prostate cancer research, including a new immunotherapy approach for renal cell carcinoma and what emerging research could mean for patients.
Register: bit.ly/4eMQE6O
We're heading to #ESMO26!
City of Hope faculty, researchers and clinicians will be presenting across a wide range of sessions covering breast cancer, genitourinary cancers, gastrointestinal cancers, cancer nursing and more.
Visit us at Booth No. 8038 to connect!
City of Hope retweeted
Saro Armenian Highlights Robert Stone’s Patient-Centered Leadership at City of Hope
@ArmenianSaro @cityofhope
oncodaily.com/voices/saro-ar…
City of Hope researchers are uncovering new evidence that structured exercise programs, tailored to individuals and their specific disease, may provide life changing benefits for patients with cancer.
Read more: bit.ly/4jmMZjA
